Prof. MELTEM MÜFTÜOĞLU

Publication Network

Articles 42

1. Association of Mitochondrial DNA Copy Number Variations with Triple-Negative Breast Cancer: A Potential Biomarker Study

Manto K., Ustun Yilmaz S., PALA KARA Z., KARA H., TOKAT F., AKYERLİ BOYLU C., et al.

DISEASES , vol.13, no.6, 2025 (ESCI, Scopus) Sustainable Development

2. Preparation and Characterization of Hydrophobin 4-Coated Liposomes for Doxorubicin Delivery to Cancer Cells.

Osmanagaoglu F. H., Ekmekcioglu A., Ozcan B., Bayram Akcapinar G., Muftuoglu M.

Pharmaceuticals (Basel, Switzerland) , vol.17, no.11, 2024 (SCI-Expanded, Scopus)

3. Mitochondria-Targeted Liposomes for Drug Delivery to Tumor Mitochondria

Ekmekçioğlu A., Gök Özatay Ö., Öz Arslan D., Erdal M. S., Uzuner Y., Müftüoğlu M.

PHARMACEUTICS , vol.16, no.7, pp.950-968, 2024 (SCI-Expanded, Scopus)

4. Cosmic Whirl: Navigating the Comet Trail in DNA: H2AX Phosphorylation and the Enigma of Uncertain Significance Variants.

Ustun Yilmaz S., Agaoglu N. B., Manto K., Muftuoglu M., Özbek U.

Genes , vol.15, no.6, 2024 (SCI-Expanded, Scopus)

5. Formulation development and evaluation of fluvastatin loaded transethosomes: Characterization, stability, in vitro dermal penetration, cytotoxicity and antipsoriatic activity studies

Yurtsever A. G., Ekmekcioglu A., Müftüoğlu M., Güngör S., Erdal M. S.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY , vol.91, pp.1-13, 2023 (SCI-Expanded, Scopus)

6. P050 Functional characterization of genomic variants of uncertain significance (VUS) in the ATM gene

Yilmaz S. U., Manto K., Ozdemir O., Agaoglu N., Ng O. H., Müftüoğlu M., et al.

BREAST , vol.68, pp.534-535, 2023 (SCI-Expanded, Scopus)

7. Association of mtDNA Copy Number Variations with Neoadjuvant in Triple Negative Breast Cancer Patients

Manto K., Yilmaz S. U., PALA KARA Z., URAS C., TOKAT F., İNCE Ü., et al.

BREAST , 2023 (SCI-Expanded, Scopus)

8. Leukocyte telomere length as a compensatory mechanism in vitamin D metabolism

AĞIRBAŞLI D., Kalyoncu M., MÜFTÜOĞLU M., Aksungar F., Agirbasli M.

PLOS ONE , vol.17, no.2, 2022 (SCI-Expanded, Scopus)

9. Targeting mitochondrial DNA polymerase gamma for selective inhibition of MLH1 deficient colon cancer growth

Somuncu B., Ekmekcioglu A., Antmen F. M., Ertuzun T., Deniz E., Keskin N., et al.

PLOS ONE , vol.17, no.6, 2022 (SCI-Expanded, Scopus) Sustainable Development

10. Anti-proliferative effects of indomethacin, acemetacin and their tromethamine salts in HCT116 human colon cancer cells

Cihan Üstündağ G., Somuncu B., Müftüoğlu M., Karalı L. N.

JOURNAL OF PHARMACY OF ISTANBUL UNIVERSITY , vol.51, pp.161-166, 2021 (ESCI, TRDizin) Sustainable Development

11. Genetics of Rare Diseases with Defective DNA Repair and Their Current Treatments

Müftüoğlu M., Ekmekçioğlu A., Kalyoncu M.

Türkiye Klinikleri Tıbbi Genetik , vol.1, pp.69-77, 2021 (TRDizin)

12. 5-Hydroxyuracil Incision Activity Varies According to the Histological Grade of Non-muscle-invasive Bladder Cancer

Keskin M. S., Antmen F. M., Somuncu B., Sağlıcan Y., Doganca T., Öbek C., et al.

UROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY , vol.20, no.1, pp.45-48, 2021 (ESCI) Sustainable Development

13. Parents of ataxia-telangiectasia patients display a distinct cellular immune phenotype mimickingATM-mutated patients

Öğülür İ., Ertuzun T., Kocamış B., Kendir Demirkol Y., Uyar E., Kıykım A., et al.

PEDIATRIC ALLERGY AND IMMUNOLOGY , vol.32, no.2, pp.349-357, 2021 (SCI-Expanded, Scopus)

14. Bacillus Calmette-Guerin Increases Base Excision Repair in Bladder Cancer Cells

Keskin M. S., Somuncu B., Müftüoğlu M.

Journal of Urological Surgery , vol.8, no.1, pp.8-12, 2021 (Peer-Reviewed Journal) Sustainable Development

15. Non-muscle invasive bladder cancer tissues have increased base excision repair capacity

Somuncu B., Keskin S., Antmen F., Saglican Y., Ekmekcioglu A., Ertuzun T., et al.

SCIENTIFIC REPORTS , vol.10, no.1, 2020 (SCI-Expanded, Scopus)

16. Investigation of base excision repair gene variants in late-onset Alzheimer's disease.

Ertuzun T., Semerci A., Cakir M. E., Ekmekçioğlu A., Gok M. O., Soltys D. T., et al.

PloS one , vol.14, 2019 (SCI-Expanded, Scopus)

17. Type I IFN-related NETosis in ataxia telangiectasia and Artemis deficiency.

Gul E., Sayar E., Gungor B., Eroglu F., Surucu N., Keles S., et al.

The Journal of allergy and clinical immunology , vol.142, pp.246-257, 2018 (SCI-Expanded, Scopus)

18. Formation and repair of oxidative damage in the mitochondrial DNA

Müftüoğlu M., Mori M. P., De Souza-Pinto N. C.

MITOCHONDRION , vol.17, pp.164-181, 2014 (SCI-Expanded, Scopus)

19. Cockayne Syndrome group B protein stimulates NEIL2 DNA glycosylase activity

Aamann M. D., Hvitby C., Popuri V., Muftuoglu M., Lemminger L., Skeby C. K., et al.

MECHANISMS OF AGEING AND DEVELOPMENT , vol.135, pp.1-14, 2014 (SCI-Expanded, Scopus)

20. PHARMACOLOGIC INHIBITION OF C-JUN N-TERMINAL KINASE (JNK) SIGNALING PATHWAY INHIBITS PROLIFERATION, BLOCKS CELL CYCLE PROGRESSION AND INDUCES APOPTOSIS OF HUMAN GRANULOSA CELL TUMOR

Oktem O., Taskiran C., MÜFTÜOĞLU M., Ata B., Senbabaoglu F., ARVAS M. B., et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER , no.8, 2013 (SCI-Expanded, Scopus)

21. Multiple interaction partners for Cockayne syndrome proteins: Implications for genome and transcriptome maintenance

Aamann M. D., Muftuoglu M., Bohr V. A., Stevnsner T.

MECHANISMS OF AGEING AND DEVELOPMENT , vol.134, pp.212-224, 2013 (SCI-Expanded, Scopus)

22. Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane

Aamann M. D., Sorensen M. M., Hvitby C., Berquist B. R., Muftuoglu M., Tian J., et al.

FASEB JOURNAL , vol.24, no.7, pp.2334-2346, 2010 (SCI-Expanded, Scopus) Sustainable Development

23. The Recombination Protein RAD52 Cooperates with the Excision Repair Protein OGG1 for the Repair of Oxidative Lesions in Mammalian Cells

de Souza-Pinto N. C., Maynard S., Hashiguchi K., Hu J., Muftuoglu M., Bohr V. A.

MOLECULAR AND CELLULAR BIOLOGY , vol.29, no.16, pp.4441-4454, 2009 (SCI-Expanded, Scopus) Sustainable Development

24. Cockayne Syndrome Group B Protein Stimulates Repair of Formamidopyrimidines by NEIL1 DNA Glycosylase

MÜFTÜOĞLU M., de Souza-Pinto N. C., Dogan A., Aamann M., Stevnsner T., Rybanska I., et al.

JOURNAL OF BIOLOGICAL CHEMISTRY , vol.284, no.14, pp.9270-9279, 2009 (SCI-Expanded, Scopus)

25. Mitochondrial Respiratory Chain Enzyme Activities, mtDNA Variants and Gene Expression Levels in Idiopathic Parkinson's Disease

ERCAN A., Kulaksiz G., Dalmizrak O., Muftuoglu M., Ogus H., Cavdar L., et al.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI , vol.34, no.2, pp.97-104, 2009 (SCI-Expanded, Scopus, TRDizin)

26. The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis

Muftuoglu M., Oshima J., von Kobbe C., Cheng W., Leistritz D. F., Bohr V. A.

HUMAN GENETICS , vol.124, no.4, pp.369-377, 2008 (SCI-Expanded, Scopus)

27. Intrinsic ssDNA annealing activity in the C-terminal region of WRN

Muftuoglu M., Kulikowicz T., Beck G., Lee J. W., Piotrowski J., Bohr V. A.

BIOCHEMISTRY , vol.47, no.39, pp.10247-10254, 2008 (SCI-Expanded, Scopus)

28. WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks

Cheng W., Muftic D., Muftuoglu M., Dawut L., Morris C., Helleday T., et al.

MOLECULAR BIOLOGY OF THE CELL , vol.19, no.9, pp.3923-3933, 2008 (SCI-Expanded, Scopus)

29. The role of Cockayne Syndrome group B (CSB) protein in base excision repair and aging

Stevnsner T., Muftuoglu M., Aamann M. D., Bohr V. A.

MECHANISMS OF AGEING AND DEVELOPMENT , vol.129, pp.441-448, 2008 (SCI-Expanded, Scopus)

30. Acetylation Regulates WRN Catalytic Activities and Affects Base Excision DNA Repair

Muftuoglu M., Kusumoto R., Speina E., Beck G., Cheng W., Bohr V. A.

PLOS ONE , vol.3, no.4, 2008 (SCI-Expanded, Scopus)

31. Werner syndrome protein: Functions in the response to DNA damage and replication stress in S-phase

Cheng W., Muftuoglu M., Bohr V. A.

EXPERIMENTAL GERONTOLOGY , vol.42, no.9, pp.871-878, 2007 (SCI-Expanded, Scopus)

32. Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates

Wong H., Muftuoglu M., Beck G., Imam S. Z., Bohr V. A., Wilson D. M.

NUCLEIC ACIDS RESEARCH , vol.35, no.12, pp.4103-4113, 2007 (SCI-Expanded, Scopus)

33. The role of WRN in DNA repair is affected by post-translational modifications

Kusumoto R., Muftuoglu M., Bohr V. A.

MECHANISMS OF AGEING AND DEVELOPMENT , vol.128, no.1, pp.50-57, 2007 (SCI-Expanded, Scopus)

34. Telomere repeat binding factor 2 interacts with base excision repair proteins and stimulates DNA synthesis by DNA polymerase beta

Muftuoglu M., Wong H., Imam S., Wilson D., Bohr V., Opresko P.

CANCER RESEARCH , vol.66, no.1, pp.113-124, 2006 (SCI-Expanded, Scopus)

35. Cockayne syndrome group B protein has novel strand annealing and exchange activities

Muftuoglu M., Sharma S., Thorslund T., Stevnsner T., Soerensen M., Brosh R., et al.

NUCLEIC ACIDS RESEARCH , vol.34, no.1, pp.295-304, 2006 (SCI-Expanded, Scopus)

36. Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations

Muftuoglu M., Elibol B., Dalmizrak O., Ercan A., Kulaksiz G., Ogus H., et al.

MOVEMENT DISORDERS , vol.19, no.5, pp.544-548, 2004 (SCI-Expanded, Scopus)

37. Differential requirement for the ATPase domain of the Cockayne syndrome group B gene in the processing of UV-induced DNA damage and 8-oxoguanine lesions in human cells

Selzer R., Nyaga S., Tuo J., May A., Muftuoglu M., Christiansen M., et al.

NUCLEIC ACIDS RESEARCH , vol.30, no.3, pp.782-793, 2002 (SCI-Expanded, Scopus)

38. Phenotypic consequences of mutations in the conserved motifs of the putative helicase domain of the human Cockayne Syndrome Group B gene

Muftuoglu M., Selzer R., Tuo J., Brosh R., Bohr V.

GENE , vol.283, pp.27-40, 2002 (SCI-Expanded, Scopus)

39. The Cockayne Syndrome group B gene product is involved in general genome base excision repair of 8-hydroxyguanine in DNA

Tuo J., Muftuoglu M., Chen C., Jaruga P., Selzer R., Brosh R., et al.

JOURNAL OF BIOLOGICAL CHEMISTRY , vol.276, no.49, pp.45772-45779, 2001 (SCI-Expanded, Scopus)

40. Simple, high-yield purification of xanthine oxidase from bovine milk

Ozer N., Muftuoglu M., Ataman D., Ercan A., Ogus I.

JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS , vol.39, no.3, pp.153-159, 1999 (SCI-Expanded, Scopus)

41. The in vitro effects of the antimalarial drug primaquine, on the activities of some enzymes in human erythrocyte lyzates

Muftuoglu M., ÖZER N.

Turkish Journal of Medical Sciences , vol.29, no.4, pp.409-412, 1999 (SCI-Expanded, Scopus, TRDizin)

42. A simple and sensitive method for the activity staining of xanthine oxidase

Ozer N., Muftuoglu M., Ogus I.

JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS , vol.36, pp.95-100, 1998 (SCI-Expanded, Scopus)

Papers Presented at Peer-Reviewed Scientific Conferences 23

1. Gestasyonel diabetes mellitusun mitokondriyal dinamiklere etkisinin değerlendirilmesi.

Abalı S., Öz Arslan D., Güner Yılmaz B., Çelik M., Koç B., Müftüoğlu M., et al.

32. Ulusal Neontoloji Kongresi, Antalya, Turkey, 17 - 20 April 2025, pp.68-69, (Summary Text)

2. Does gestational diabetes mellitus influence mitochondrial dynamics in offspring?

Abalı S., Öz Arslan D., Güner Yılmaz B., Çelik M., Koç B., Müftüoğlu M., et al.

The 62nd ESPE Annual Meeting , Liverpool, England, 16 - 18 November 2024, vol.97, pp.133-134, (Summary Text)

3. Valproik asit ile indüklenen otizm modelinde mitokondriyal dinamiklerin gelişimsel süreçte incelenmesi

ÖZER S., SARI E., ERKAYA M., DARILMAZ İ., ÖZ ARSLAN D., MÜFTÜOĞLU M., et al.

20. Ulusal Sinirbilim Kongresi, İstanbul, Turkey, 19 October 2022, (Summary Text)

4. Enhanced activity of plasminogen activator inhibitor 1 (PAI-1) in neurodegenerative diseases

MÜFTÜOĞLU M., AĞIRBAŞLI D., Ağırbaşlı M.

ACC Middle East 2022 Together With 13th Emirates Cardiac Society Congress, Dubai, United Arab Emirates, 07 October 2022, (Summary Text)

5. KALITSAL KANSERLERDE KLİNİK ÖNEMİ BİLİNMEYEN GENOMİK VARYANTLARIN FONKSİYONEL KARAKTERİZASYONU VE SINIFLANDIRILMASI

Üstün Yılmaz S., Özdemir Ö., AĞAOĞLU N. B., HATIRNAZ NG Ö., MÜFTÜOĞLU M., ÖZBEK U.

8.TÜRK TIBBİ ONKOLOJİ KONGRESİ, Antalya, Turkey, 3 - 07 November 2021, (Full Text) Sustainable Development

6. Fluvastatin Sodium Loaded Nanovesicular Carriers: Formulation Development, Characterization and In vitro Cell Culture Studies

GÜRBÜZ A., GÜNGÖR S., MÜFTÜOĞLU M., Ekmekcioglu A., ERDAL M. S.

CRS2021 Virtual Annual Meeting, United States Of America, 25 July 2021 - 25 October 2022, (Summary Text)

7. Enhanced Base Excision Repair Capacity Associated With Progression of Non-Muscle Invasive Bladder Cancer

KESKİN M. S., ANTMEN F. M., Somuncu B., SAĞLICAN Y., ERTÜZÜN T., TUNA M. B., et al.

14. Üroonkoloji Kongresi, Antalya, Turkey, 6 - 10 November 2019, (Summary Text)

8. D vitamini takviyesinin serum D vitamini seviyeleri ve telomere etkisi

Ağırbaşlı D., Kalyoncu M., Ağırbaşlı M. A., Müftüoğlu M.

16. Uluslararası Katılımlı Tıbbi Biyoloji ve Genetik Kongresi, Muğla, Turkey, 27 - 30 October 2019, vol.1, pp.76, (Summary Text)

9. Association of Vitamin D levels with leukocyte telomere length in postmenopausal women

Kalyoncu M., Ağırbaşlı D., Müftüoğlu M., Onur İ., Ağırbaşlı M.

International Moelcular Medicine Symposium, İstanbul, Turkey, 16 - 18 May 2019, vol.1, pp.101, (Summary Text)

10. Ataksi Telenjiektazi Hastalarının Ebeveynlerinde Enfeksiyonlar ve Lenfosit Alt Grup Bozuklukları

ÖĞÜLÜR İ., Ertüzün T., ÖZEN A. O., UYAR E., KIYKIM A., Başer D., et al.

XXV. Ulusal Allerji ve Klinik İmmünoloji Kongresi, Antalya, Turkey, 17 - 21 November 2018, (Full Text)

11. Kasa İnvaze Olmayan Mesane Tümöründe Artmış Apürinik/Apirimidinik Endonükleaz Aktivitesi

KESKİN M. S., SOMUNCU B., ANTMEN F. M., SAĞLICAN Y., ERTÜZÜN T., TUNA M. B., et al.

4. Ulusal Ürolojik Cerrahi Kongresi, Antalya, Turkey, 31 October - 04 November 2018, (Summary Text)

12. Kasa İnvaze Olmayan Mesane Tümöründe Artmış Apurinic/Apirimidinik Endonükleaz Aktivitesi

KESKİN M. S., Somuncu B., ANTMEN F. M., SAĞLICAN Y., ERTÜZÜN T., TUNA M. B., et al.

4.Üroloji Cerrahi Kongresi, Antalya, Turkey, 31 October - 04 November 2018, (Summary Text)

13. INFECTIONS AND LYMPHOCYTE SUBSET ALTERATIONS IN ATAXIA TELANGIECTASIA MUTATED KINASE CARRIERS

ÖĞÜLÜR İ., Ertüzün T., ÖZEN A. O., UYAR E., KIYKIM A., Başer D., et al.

18th Biennial Meeting of ESID, Lizbon, Portugal, 24 - 27 October 2018, (Summary Text)

14. Enhanced Apurinic/Apyrimidinic Endonuclease Activity in Non-Muscle Invasive Bladder Cancer

KESKİN M. S., SOMUNCU B., ANTMEN M., SAĞLICAN Y., ERTÜZÜN T., Tuna M. B., et al.

36th World Congress of Endourology, Paris, France, 20 - 23 September 2018, (Summary Text) Sustainable Development

15. Identification and characterization of small molecule inhibitors targeting DNA polymerase gamma for the treatment of cancers deficient in mismatch repair

Pamukcu C., Keskin N., Aydin D., Gulser I. E., Deniz E., Erman M. B., et al.

40th Congress of the Federation-of-European-Biochemical-Societies (FEBS) - The Biochemical Basis of Life, Berlin, Germany, 4 - 09 July 2015, vol.282, pp.270-271, (Summary Text) Sustainable Development

16. REAL TIME AND QUANTITATIVE ASSESSMENT OF THE EFFECTS OF DIFFERENT OVARIAN STIMULATION PROTOCOLS ON THE PROLIFERATION AND CELL CYCLE KINETICS OF GRANULOSA CELLS USING A NEW IMPEDENCE-BASED SYSTEM.

Oktem O., Muftuoglu M., Senbabaoglu F., Urman B.

International-Federation-of-Fertility-Societies 21st World Congress on Fertility and Sterility / 69th Annual Meeting of the American-Society-for-Reproductive-Medicine, Massachusetts, United States Of America, 12 - 17 October 2013, vol.100, (Summary Text)

17. The involvement of Cockayne syndrome B protein in base excision repair

Muftuoglu M., Aamann M. D., Stevnsner T., Bohr V. A.

38th Congress of the Federation-of-European-Biochemical-Societies (FEBS), Saint Peter, Guernsey And Alderney, 6 - 11 July 2013, vol.280, pp.62, (Summary Text)

18. Real-time analysis of the growth of human granulosa cells using an impedance-based signal processing system: a new technology for translational research in human reproduction

Oktem O., Muftuoglu M., Senbabaoglu F., Urman B.

29th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), London, Canada, 7 - 10 July 2013, vol.28, pp.54-55, (Summary Text)

19. Effect of pharmacologic inhibition of c-Jun N-terminal kinase (JNK) signaling pathway on cell proliferation and cell cycle progression in human granulosa cell tumor

Oktem O., Muftuoglu M., Senbabaoglu F., Urman B.

49th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Illinois, United States Of America, 31 May - 04 June 2013, vol.31, (Summary Text)

20. Base excision repair pathway at telomeric DNA

Muftuoglu M., Opresko P., Bohr V.

31st Congress of the Federation-of-European-Biochemical-Societies (FEBS), İstanbul, Turkey, 24 - 29 June 2006, vol.273, pp.54, (Summary Text)

21. Mitochondrial complex I and IV activities, ND2, ND4 gene mutations and expressions in idiopathic Parkinson's disease

Ercan A., Kulaksiz G., Muftuoglu M., Dalmizrak O., Ogus H., Cavdar L., et al.

31st Congress of the Federation-of-European-Biochemical-Societies (FEBS), İstanbul, Turkey, 24 - 29 June 2006, vol.273, pp.244-245, (Summary Text)

22. Mitochondrial complex I and complex IV activities in lymphocytes from patients with Parkin gene mutations

Dalmizrak O., Muftuoglu M., Atac F., Ogus J., Ozer N., Elibol B.

7th International Congress of Parkinsons Disease and Movement Disorders, MIAMI, FLORIDA, 10 - 14 November 2002, vol.17, (Summary Text)

23. The effects of oxidative stress on the redox system of the human erythrocyte

Ogus I., Balk M., Aksoy Y., MÜFTÜOĞLU M., Ozer N.

NATO Advanced Study Institute on Free Radicals, Oxidative Stress, and Antioxidants - Pathological and Physiological Significance, Antalya, Turkey, 24 May - 04 June 1997, pp.25-37, (Full Text)

Books 7