Acetylation Regulates WRN Catalytic Activities and Affects Base Excision DNA Repair


Creative Commons License

Muftuoglu M., Kusumoto R., Speina E., Beck G., Cheng W., Bohr V. A.

PLOS ONE, vol.3, no.4, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 3 Issue: 4
  • Publication Date: 2008
  • Doi Number: 10.1371/journal.pone.0001918
  • Journal Name: PLOS ONE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Background: The Werner protein (WRN), defective in the premature aging disorder Werner syndrome, participates in a number of DNA metabolic processes, and we have been interested in the possible regulation of its function in DNA repair by post-translational modifications. Acetylation mediated by histone acetyltransferases is of key interest because of its potential importance in aging, DNA repair and transcription.