Acetylation Regulates WRN Catalytic Activities and Affects Base Excision DNA Repair

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Muftuoglu M., Kusumoto R., Speina E., Beck G., Cheng W., Bohr V. A.

PLOS ONE, vol.3, no.4, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 3 Issue: 4
  • Publication Date: 2008
  • Doi Number: 10.1371/journal.pone.0001918
  • Journal Name: PLOS ONE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Background: The Werner protein (WRN), defective in the premature aging disorder Werner syndrome, participates in a number of DNA metabolic processes, and we have been interested in the possible regulation of its function in DNA repair by post-translational modifications. Acetylation mediated by histone acetyltransferases is of key interest because of its potential importance in aging, DNA repair and transcription.