Acetylation Regulates WRN Catalytic Activities and Affects Base Excision DNA Repair


Muftuoglu M. , Kusumoto R., Speina E., Beck G., Cheng W., Bohr V. A.

PLOS ONE, cilt.3, 2008 (SCI İndekslerine Giren Dergi)

Özet

Background: The Werner protein (WRN), defective in the premature aging disorder Werner syndrome, participates in a number of DNA metabolic processes, and we have been interested in the possible regulation of its function in DNA repair by post-translational modifications. Acetylation mediated by histone acetyltransferases is of key interest because of its potential importance in aging, DNA repair and transcription.