The role of Cockayne Syndrome group B (CSB) protein in base excision repair and aging


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Stevnsner T., Muftuoglu M., Aamann M. D., Bohr V. A.

MECHANISMS OF AGEING AND DEVELOPMENT, cilt.129, ss.441-448, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 129
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.mad.2008.04.009
  • Dergi Adı: MECHANISMS OF AGEING AND DEVELOPMENT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.441-448
  • Anahtar Kelimeler: Cockayne Syndrome, oxidative damage, base excision repair, aging, RNA-POLYMERASE-II, COUPLING FACTOR CSB/ERCC6, INDUCED DNA-DAMAGE, OXIDATIVE STRESS, GENE-PRODUCT, PREFERENTIAL REPAIR, TRANSCRIBED STRAND, INDUCED APOPTOSIS, MAMMALIAN-CELLS, HELICASE DOMAIN
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Cockayne Syndrome (CS) is a rare human genetic disorder characterized by progressive multisystem degeneration and segmental premature aging. The CS complementation group B (CSB) protein is engaged in transcription coupled and global nucleotide excision repair, base excision repair and general transcription. However, the precise molecular function of the CSB protein is still unclear. In the current review we discuss the involvement of CSB in some of these processes, with focus on the role of CSB in repair of oxidative damage, as deficiencies in the repair of these lesions may be an important aspect of the premature aging phenotype of CS. (C) 2008 Elsevier Ireland Ltd. All rights reserved.