The role of Cockayne Syndrome group B (CSB) protein in base excision repair and aging


Stevnsner T., Muftuoglu M. , Aamann M. D. , Bohr V. A.

MECHANISMS OF AGEING AND DEVELOPMENT, vol.129, pp.441-448, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 129
  • Publication Date: 2008
  • Doi Number: 10.1016/j.mad.2008.04.009
  • Title of Journal : MECHANISMS OF AGEING AND DEVELOPMENT
  • Page Numbers: pp.441-448

Abstract

Cockayne Syndrome (CS) is a rare human genetic disorder characterized by progressive multisystem degeneration and segmental premature aging. The CS complementation group B (CSB) protein is engaged in transcription coupled and global nucleotide excision repair, base excision repair and general transcription. However, the precise molecular function of the CSB protein is still unclear. In the current review we discuss the involvement of CSB in some of these processes, with focus on the role of CSB in repair of oxidative damage, as deficiencies in the repair of these lesions may be an important aspect of the premature aging phenotype of CS. (C) 2008 Elsevier Ireland Ltd. All rights reserved.