5-Hydroxyuracil Incision Activity Varies According to the Histological Grade of Non-muscle-invasive Bladder Cancer

Keskin, Mehmet; Antmen, Fatma; Somuncu, Berna; Sağlıcan, Yeşim; Doganca, Tunkut; Öbek, CAN; İnce, ÜMİT; Kural, ALİ; Müftüoğlu, MELTEM

doi:10.4274/uob.galenos.2021.2021-1-8

5-Hydroxyuracil Incision Activity Varies According to the Histological Grade of Non-muscle-invasive Bladder Cancer

Atıf İçin Kopyala

Keskin M. S., Antmen F. M., Somuncu B., Sağlıcan Y., Doganca T., Öbek C., ...Daha Fazla

UROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY, cilt.20, ss.45-48, 2021 (ESCI)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 20
Basım Tarihi: 2021
Doi Numarası: 10.4274/uob.galenos.2021.2021-1-8
Dergi Adı: UROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.45-48
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Objective: High levels of endonuclease III-like 1 (NTHL1) DNA glycosylase, which plays a role in the first step of the base excision repair pathway, has been related to cancer initiation and progression. 5-hydroxyuracil (5-OHU) oxidative base damage is a substrate for NTHL1 and endonuclease VIII-like 1 enzyme 1 (NEIL1) DNA glycosylases. This study investigates the association of 5-OHU incision activity with the risk of disease progression in patients with non-muscle-invasive bladder cancer (NMIBC) regarding grade and stage.