5-Hydroxyuracil Incision Activity Varies According to the Histological Grade of Non-muscle-invasive Bladder Cancer


KESKİN M. S. , Antmen F. M. , SOMUNCU B., SAĞLICAN Y. , Doganca T., Öbek C. , ...More

The Bulletin of Urooncology, vol.20, pp.45-48, 2021 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 20
  • Publication Date: 2021
  • Doi Number: 10.4274/uob.galenos.2021.2021-1-8
  • Title of Journal : The Bulletin of Urooncology
  • Page Numbers: pp.45-48

Abstract

Objective: High levels of endonuclease III-like 1 (NTHL1) DNA glycosylase, which plays a role in the first step of the base excision repair pathway, has been related to cancer initiation and progression. 5-hydroxyuracil (5-OHU) oxidative base damage is a substrate for NTHL1 and endonuclease VIII-like 1 enzyme 1 (NEIL1) DNA glycosylases. This study investigates the association of 5-OHU incision activity with the risk of disease progression in patients with non-muscle-invasive bladder cancer (NMIBC) regarding grade and stage.