Bacillus Calmette-Guerin Increases Base Excision Repair in Bladder Cancer Cells


KESKİN M. S. , SOMUNCU B., MÜFTÜOĞLU M.

Journal of Urological Surgery, vol.8, no.1, pp.8-12, 2021 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.4274/jus.galenos.2020.0013
  • Title of Journal : Journal of Urological Surgery
  • Page Numbers: pp.8-12

Abstract

Objective: Most patients with non-muscle-invasive bladder cancer (NMIBC) do not respond to intravesical Bacillus Calmette-Guerin (BCG) immunotherapy and have high risk of NMIBC recurrence and progression. In addition to its therapeutic effect which increases the local immune response, BCG also exerts an anti-tumour effect by increasing oxidative stress, and producing reactive oxygen species and oxidative DNA damage in bladder cancer (BC) cells. The oxidative DNA damage is repaired by base excision repair (BER) mechanism. Thus, BER capacity of BC cells could be an important factor in response to BCG therapy. Effects of BCG on the activity of BER in BC transitional carcinoma cell line, T24 have been investigated.