Mitochondrial Respiratory Chain Enzyme Activities, mtDNA Variants and Gene Expression Levels in Idiopathic Parkinson's Disease


ERCAN A., Kulaksiz G., Dalmizrak O., Muftuoglu M., Ogus H., Cavdar L., ...More

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.34, no.2, pp.97-104, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 2
  • Publication Date: 2009
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.97-104
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Purpose: Mitochondrial dysfunction has been implicated in the development of idiopathic Parkinson's disease. In this study, it was aimed to investigate the relationship between mitochondrial respiratory chain enzyme deficiency and variants in ND2 and ND4 region of Complex I and expressions of these genes. Complex IV activity and glutathione level were also studied.