Mitochondrial Respiratory Chain Enzyme Activities, mtDNA Variants and Gene Expression Levels in Idiopathic Parkinson's Disease


ERCAN A., Kulaksiz G., Dalmizrak O., Muftuoglu M. , Ogus H., Cavdar L., et al.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.34, ss.97-104, 2009 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 34 Konu: 2
  • Basım Tarihi: 2009
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Sayfa Sayısı: ss.97-104

Özet

Purpose: Mitochondrial dysfunction has been implicated in the development of idiopathic Parkinson's disease. In this study, it was aimed to investigate the relationship between mitochondrial respiratory chain enzyme deficiency and variants in ND2 and ND4 region of Complex I and expressions of these genes. Complex IV activity and glutathione level were also studied.