The role of WRN in DNA repair is affected by post-translational modifications

Kusumoto R., Muftuoglu M., Bohr V. A.

MECHANISMS OF AGEING AND DEVELOPMENT, vol.128, no.1, pp.50-57, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 128 Issue: 1
  • Publication Date: 2007
  • Doi Number: 10.1016/j.mad.2006.11.010
  • Journal Name: MECHANISMS OF AGEING AND DEVELOPMENT
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.50-57
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Werner syndrome (WS) is an autosomal recessive progeroid disease characterized by genomic instability. WRN gene encodes one of the RecQ helicase family proteins, WRN, which has ATPase, helicase, exonuclease and single stranded DNA annealing activities. There is accumulating evidence suggesting that WRN contributes to the maintenance of genomic integrity through its involvement in DNA repair, replication and recombination. The role of WRN in these pathways can be modulated by its post-translational modifications in response to DNA damage. Here, we review the functional consequences of post-translational modifications on WRN as well as specific DNA repair pathways where WRN is involved and discuss how these modifications affect DNA repair pathways. Published by Elsevier Ireland Ltd.