Eğitim Bilgileri
1991 - 1998
1991 - 1998Doktora
Brandeis University, Faculty of Arts and Sciences, Biology Department, Amerika Birleşik Devletleri
1987 - 1991
1987 - 1991Lisans
Hamilton College, Biology, Amerika Birleşik Devletleri
Yabancı Diller
C1 İleri
C1 İleriİngilizce
Araştırma Alanları
İmmünoloji ve Romatoloji
Yapısal Biyofizik
Moleküler Biyokimya
Yapısal Biyoloji
Endüstriyel Biyoteknoloji
İmmünoloji
Genetik Bozuklukların Moleküler Biyolojisi
Genetik Mühendisliği
Genomiks
Hayvan Moleküler Genetiği
Kanser Moleküler Biyolojisi
Protein Mühendisliği
Akademik Unvanlar / Görevler
2021 - 2024
2021 - 2024Prof. Dr.
Boğaziçi Üniversitesi, Faculty of Arts and Sciences, Department of Molecular Biology and Genetics
2015 - 2021
2015 - 2021Prof. Dr.
Sabancı Üniversitesi, Faculty of Engineering and Natural Sciences, Molecular Biology, Genetics and Bioengineering
2005 - 2015
2005 - 2015Doç. Dr.
Sabancı Üniversitesi, Faculty of Engineering and Natural Sciences, Molecular Biology, Genetics and Bioengineering
Yönetimsel Görevler
2022 - 2024
2022 - 2024Anabilim/Bilim Dalı Başkanı
Boğaziçi Üniversitesi, Faculty of Arts and Sciences, Molecular Biology and Genetics
Akademi Dışı Deneyim
2021 - Devam Ediyor
2021 - Devam EdiyorPresident
Meslek Birliği, Moleküler Biyoloji Derneği, Moleküler Biyoloji Derneği, President
SCI, SSCI ve AHCI İndekslerine Giren Dergilerde Yayınlanan Makaleler
2024
2024Dimerization choice and alternative functions of ZBTB transcription factors
Barakat S., Ezen E., Devecioglu I., Gezen M., Piepoli S., ERMAN M. B.
FEBS JOURNAL
, cilt.291, sa.2, ss.237-255, 2024 (SCI-Expanded)
2024
2024Evaluation of Clinical and Immunological Alterations Associated with ICF Syndrome
Bilgic Eltan S., Nain E., Catak M. C., Ezen E., Sefer A. P., Karimi N., et al.
JOURNAL OF CLINICAL IMMUNOLOGY
, cilt.44, sa.1, 2024 (SCI-Expanded)
2023
2023Expression and characterization of recombinant IL-1Ra in <i>Aspergillus oryzae</i> as a system
Azar L. M., KARAMAN E., Beyaz B., Goktan I., Eyupoglu A. E., Kizilel S., et al.
BMC BIOTECHNOLOGY
, cilt.23, sa.1, 2023 (SCI-Expanded)
2023
2023Human ACE2 orthologous peptide sequences show better binding affinity to SARS-CoV-2 RBD domain: Implications for drug design
Azar L. M., Oncel M. M., KARAMAN E., Soysal L. F., FATIMA A., Choi S. B., et al.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
, cilt.21, ss.4096-4109, 2023 (SCI-Expanded)
2022
2022Sibling rivalry among the ZBTB transcription factor family: homodimers versus heterodimers
Piepoli S., Barakat S., Nogay L., Simsek B., Akkose U., Taskiran H., et al.
LIFE SCIENCE ALLIANCE
, cilt.5, sa.11, 2022 (SCI-Expanded)
2022
2022Targeting mitochondrial DNA polymerase gamma for selective inhibition of MLH1 deficient colon cancer growth
Somuncu B., Ekmekcioglu A., Antmen F. M., Ertuzun T., Deniz E., Keskin N., et al.
PLOS ONE
, cilt.17, sa.6 June, 2022 (SCI-Expanded)
2022
2022Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus
Shinzawa M., Moseman E. A., Gossa S., Mano Y., Bhattacharya A., Guinter T., et al.
NATURE IMMUNOLOGY
, cilt.23, sa.5, ss.731-742, 2022 (SCI-Expanded)
2022
2022Nanobodies as molecular imaging probes
Barakat S., Berksoz M., Zahedimaram P., Piepoli S., ERMAN M. B.
FREE RADICAL BIOLOGY AND MEDICINE
, cilt.182, ss.260-275, 2022 (SCI-Expanded)
2021
2021Sibling rivalry among the ZBTB transcription factor family: homo vs heterodimerization
Piepoli S., Akkose U., Nogay L., Taskiran H., Tolay N., Gezen M., et al.
EUROPEAN JOURNAL OF IMMUNOLOGY
, ss.67, 2021 (SCI-Expanded)
2021
2021The mechanism of LRBA dependent CTLA-4 surface expression in regulatory T cell lymphocytes
Zahedimaram P., ERMAN M. B., Baris S.
EUROPEAN JOURNAL OF IMMUNOLOGY
, ss.359, 2021 (SCI-Expanded)
2021
2021Synchronous and Asynchronous Response in Dynamically Perturbed Proteins
Hacisuleyman A., Erkip A., ERMAN M. B., Erman B.
JOURNAL OF PHYSICAL CHEMISTRY B
, cilt.125, sa.3, ss.729-739, 2021 (SCI-Expanded)
2020
2020Structural analysis of the PATZ1 BTB domain homodimer
Piepoli S., Alt A. O., Atilgan C., Mancini E. J., ERMAN M. B.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
, cilt.76, ss.581-593, 2020 (SCI-Expanded)
2020
2020Engineering antigen-specific natural killer cells against the melanoma-associated antigen tyrosinase via TCR gene transfer.
Parlar A., Sayitoglu E. C., Pamukcu C., Georgoudaki A., Ozkazanc D., Aras M., et al.
CANCER IMMUNOLOGY RESEARCH
, sa.4, ss.49-50, 2020 (SCI-Expanded)
2020
2020p53 regulates katanin-p60 promoter in HCT 116 cells
Kirimtay K., Selcuk E., Kelle D., ERMAN M. B., Karabay Korkmaz A.
GENE
, cilt.727, 2020 (SCI-Expanded)
2020
2020Doxorubicin inhibits miR-140 expression and upregulates PD-L1 expression in HCT116 cells,opposite to its effects on MDA-MB-231 cells
Naba N. M., Tolay N., ERMAN M. B., Sayı Yazgan A.
TURKISH JOURNAL OF BIOLOGY
, cilt.44, sa.1, ss.15-23, 2020 (SCI-Expanded)
2019
2019The fungal metabolite chaetocin is a sensitizer for pro-apoptotic therapies in glioblastoma
Ozyerli-Goknar E., Sur-Erdem I., Seker F., CİNGÖZ A., Kayabolen A., Kahya-Yesil Z., et al.
CELL DEATH & DISEASE
, cilt.10, 2019 (SCI-Expanded)
2019
2019Approaches to functionally validate candidate genetic variants involved in colorectal cancer predisposition
Bonjoch L., Mur P., Arnau-Collell C., Vargas-Parra G., Shamloo B., Franch-Exposito S., et al.
MOLECULAR ASPECTS OF MEDICINE
, cilt.69, ss.27-40, 2019 (SCI-Expanded)
2019
2019Engineering antigen-specific NK cell lines against the melanoma-associated antigen tyrosinase via TCR gene transfer
Parlar A., Sayitoglu E. C., Ozkazanc D., Georgoudaki A., Pamukcu C., Aras M., et al.
EUROPEAN JOURNAL OF IMMUNOLOGY
, sa.8, ss.1278-1290, 2019 (SCI-Expanded)
2017
2017Identification of lineage-specifying cytokines that signal all CD8<SUP>+</SUP>-cytotoxic-lineage-fate 'decisions' in the thymus
Etzensperger R., Kadakia T., Tai X., Alag A., Guinter T. I., Egawa T., et al.
NATURE IMMUNOLOGY
, cilt.18, sa.11, ss.1218-1227, 2017 (SCI-Expanded)
2017
2017Long noncoding RNA (lincRNA), a new paradigm in gene expression control
Deniz E., ERMAN M. B.
FUNCTIONAL & INTEGRATIVE GENOMICS
, cilt.17, sa.2-3, ss.135-143, 2017 (SCI-Expanded)
2016
2016Screening of new antileukemic agents from essential oils of algae extracts and computational modeling of their interactions with intracellular signaling nodes
Ataseyer-Arslan B., Yilancioglu K., Kalkan Z., Timucin A. C., Gur H., Isik F. B., et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
, ss.120-131, 2016 (SCI-Expanded)
2015
2015Antileukemic Drug Potentials of Essential Oils of Algea Extracts
Arslan B. A., Yilancioglu K., Kalkan Z., Atalay V. E., Gur H., Isik F. B., et al.
ACTA PHYSIOLOGICA
, ss.15, 2015 (SCI-Expanded)
2015
2015PATZ1 Is a DNA Damage-Responsive Transcription Factor That Inhibits p53 Function
Keskin N., Deniz E., Eryilmaz J., Un M., Batur T., Ersahin T., et al.
MOLECULAR AND CELLULAR BIOLOGY
, sa.10, ss.1741-1753, 2015 (SCI-Expanded)
2014
2014Oxidative Stress Is a Mediator for Increased Lipid Accumulation in a Newly Isolated <i>Dunaliella salina</i> Strain
Yilancioglu K., Cokol M., Pastirmaci I., ERMAN M. B., Cetiner S.
PLOS ONE
, cilt.9, sa.3, 2014 (SCI-Expanded)
2013
2013Foxp3 Transcription Factor Is Proapoptotic and Lethal to Developing Regulatory T Cells unless Counterbalanced by Cytokine Survival Signals
Tai X., ERMAN M. B., Alag A., Mu J., Kimura M., Katz G., et al.
IMMUNITY
, cilt.38, sa.6, ss.1116-1128, 2013 (SCI-Expanded)
2013
2013Effects of micro environmental factors on natural killer activity (NK) of Beta Thalassemia major patients
Arslan B. A., Erdem-Kuruca S., KARAKAŞ Z., ERMAN M. B., ERGEN H. A.
CELLULAR IMMUNOLOGY
, cilt.282, sa.2, ss.93-99, 2013 (SCI-Expanded)
2012
2012Cd81 Interacts with the T Cell Receptor to Suppress Signaling
Cevik S. I., Keskin N., Belkaya S., Ozlu M. I., Deniz E., Tazebay U. H., et al.
PLOS ONE
, sa.11, 2012 (SCI-Expanded)
2012
2012Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus
McCaughtry T. M., Etzensperger R., Alag A., Tai X., Kurtulus S., Park J., et al.
JOURNAL OF EXPERIMENTAL MEDICINE
, cilt.209, sa.12, ss.2263-2276, 2012 (SCI-Expanded)
2012
2012CD8 Lineage-specific Regulation of Interleukin-7 Receptor Expression by the Transcriptional Repressor Gfi1
Ligons D. L., Tuncer C., Linowes B. A., Akcay I. M., Kurtulus S., Deniz E., et al.
JOURNAL OF BIOLOGICAL CHEMISTRY
, cilt.287, sa.41, ss.34386-34399, 2012 (SCI-Expanded)
2012
2012Coreceptor gene imprinting governs thymocyte lineage fate
Adoro S., McCaughtry T., ERMAN M. B., Alag A., Van Laethem F., Park J., et al.
EMBO JOURNAL
, cilt.31, sa.2, ss.366-377, 2012 (SCI-Expanded)
2010
2010Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells
Park J., Adoro S., Guinter T., ERMAN M. B., Alag A. S., Catalfamo M., et al.
NATURE IMMUNOLOGY
, cilt.11, sa.3, ss.257-264, 2010 (SCI-Expanded)
2009
2009Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4<SUP>+</SUP> T cells
Guimond M., Veenstra R. G., Grindler D. J., Zhang H., Cui Y., Murphy R. D., et al.
NATURE IMMUNOLOGY
, cilt.10, sa.2, ss.149-157, 2009 (SCI-Expanded)
2008
2008Targeting CD4 Coreceptor Expression to Postselection Thymocytes Reveals That CD4/CD8 Lineage Choice Is neither Error-Prone nor Stochastic
Adoro S., ERMAN M. B., Sarafova S. D., Van Laethem F., Park J., Feigenbaum L., et al.
JOURNAL OF IMMUNOLOGY
, cilt.181, sa.10, ss.6975-6983, 2008 (SCI-Expanded)
2007
2007'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR
Park J., Adoro S., Lucas P. J., Sarafova S. D., Alag A. S., Doan L. L., et al.
NATURE IMMUNOLOGY
, cilt.8, sa.10, ss.1049-1059, 2007 (SCI-Expanded)
2006
2006Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model
ERMAN M. B., Alag A. S., Dahle O., van Laethem F., Sarafova S. D., Guinter T. I., et al.
JOURNAL OF IMMUNOLOGY
, cilt.177, sa.10, ss.6613-6625, 2006 (SCI-Expanded)
2006
2006Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection
Yu Q., Park J., Doan L., ERMAN M. B., Feigenbaum L., Singer A.
JOURNAL OF EXPERIMENTAL MEDICINE
, cilt.203, sa.1, ss.165-175, 2006 (SCI-Expanded)
2005
2005Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity
Sarafova S., ERMAN M. B., Yu Q., Van Laethem F., Guinter T., Sharrow S., et al.
IMMUNITY
, cilt.23, sa.1, ss.75-87, 2005 (SCI-Expanded)
2004
2004IL-7 receptor signals inhibit expression of transcription factors TCF-1, LEF-1, and RORγt:: Impact on thymocyte development
Yu Q., ERMAN M. B., Park J., Feigenbaum L., Singer A.
JOURNAL OF EXPERIMENTAL MEDICINE
, cilt.200, sa.6, ss.797-803, 2004 (SCI-Expanded)
2004
2004Suppression of IL7Rα transcription by IL-7 and other prosurvival cytokines:: A novel mechanism for maximizing IL-7-dependent T cell survival
Park J., Yu Q., ERMAN M. B., Appelbaum J., Montoya-Durango D., Grimes J., et al.
IMMUNITY
, cilt.21, sa.2, ss.289-302, 2004 (SCI-Expanded)
2004
2004Defined αβ T cell receptors with distinct ligand specificities do not require those ligands to signal double negative thymocyte differentiation
ERMAN M. B., Guinter T., Singer A.
JOURNAL OF EXPERIMENTAL MEDICINE
, cilt.199, sa.12, ss.1719-1724, 2004 (SCI-Expanded)
2003
2003In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8<SUP>+</SUP> T cells
Yu Q., ERMAN M. B., Bhandoola A., Sharrow S., Singer A.
JOURNAL OF EXPERIMENTAL MEDICINE
, cilt.197, sa.4, ss.475-487, 2003 (SCI-Expanded)
2002
2002Early TCRα expression generates TCR complexes that signal the DN-to-DP transition and impair development
ERMAN M. B., Feigenbaum L., Coligan J., Singer A.
NATURE IMMUNOLOGY
, cilt.3, sa.6, ss.564-569, 2002 (SCI-Expanded)
1999
1999Transcriptional activation by ETS and leucine zipper-containing basic helix-loop-helix proteins
Tian G., Erman B., Ishii H., Gangopadhyay S., Sen R.
MOLECULAR AND CELLULAR BIOLOGY
, cilt.19, sa.4, ss.2946-2957, 1999 (SCI-Expanded)
1998
1998ETS-core binding factor: a common composite motif in antigen receptor gene enhancers
Erman B., Cortes M., Nikolajczyk B., Speck N., Sen R.
MOLECULAR AND CELLULAR BIOLOGY
, cilt.18, sa.3, ss.1322-1330, 1998 (SCI-Expanded)
1996
1996Context dependent transactivation domains activate the immunoglobulin mu heavy chain gene enhancer
Erman B., Sen R.
EMBO JOURNAL
, cilt.15, sa.17, ss.4665-4675, 1996 (SCI-Expanded)
1993
1993REGULATION OF LYMPHOID-SPECIFIC IMMUNOGLOBULIN-MU HEAVY-CHAIN GENE ENHANCER BY ETS-DOMAIN PROTEINS
NELSEN B., TIAN G., ERMAN B., GREGOIRE J., MAKI R., GRAVES B., et al.
SCIENCE
, sa.5117, ss.82-86, 1993 (SCI-Expanded)
1991
1991INFORMATION-THEORETICAL ENTROPY AS A MEASURE OF SEQUENCE VARIABILITY
SHENKIN P., ERMAN B., MASTRANDREA L.
PROTEINS-STRUCTURE FUNCTION AND GENETICS
, cilt.11, sa.4, ss.297-313, 1991 (SCI-Expanded)
Diğer Dergilerde Yayınlanan Makaleler
2024
2024Structure and Function of the LRBA Protein
Ezen E., Catak M. C., Catak F. B., Piepoli S., Zahedimaram P., Ultanir E., et al.
TURKISH JOURNAL OF IMMUNOLOGY
, ss.37-46, 2024 (ESCI)
2020
2020Molecular Biology of SARS-CoV-2
Piepoli S., Shamloo B., Bircan A., Adebali O., ERMAN M. B.
TURKISH JOURNAL OF IMMUNOLOGY
, cilt.8, sa.2, ss.73-88, 2020 (ESCI)
2019
2019Nanocomposite Bioinks Based on Agarose and 2D Nanosilicates with Tunable Flow Properties and Bioactivity for 3D Bioprinting
Nadernezhad A., Caliskan O. S., Topuz F., Afghah F., ERMAN M. B., Koc B.
ACS APPLIED BIO MATERIALS
, cilt.2, sa.2, ss.796-806, 2019 (ESCI)
Hakemli Bilimsel Toplantılarda Yayımlanmış Bildiriler
2021
2021Isolation and characterization of nanobodies that bind the BTB domain of the PATZ1 transcription factor
Barakat S., De Marko A., ERMAN M. B.
6th European Congress of Immunology (ECI), ELECTR NETWORK, 1 - 04 Eylül 2021, ss.412, (Özet Bildiri)
2018
2018Identification and strategic targeting of key anti-viral defense mechanisms in Natural Killer cells
Sayitoglu E. C., Ozkazanc D., Sarac A., Parlar A., Alici E., ERMAN M. B., et al.
Annual Meeting of the American-Association-of-Immunologists (AAI), Texas, Amerika Birleşik Devletleri, 4 - 08 Mayıs 2018, (Özet Bildiri)
2017
2017Engineering antigen-specific NK cells via TCR gene transfer: A novel source for adoptive immunotherapy
Parlar A., Pamukcu C., Ozkazanc D., Aras M., Dahlberg C., Chrobok M., et al.
European-Society-of-Gene-and-Cell-Therapy (ESCGT) Congress, Berlin, Almanya, 01 Ocak 2017, (Özet Bildiri)
2017
2017Editing of Long Noncoding RNA DANCR Gene Locus Using Genetic Engineering Tools
Baran G., Talug B., Keskin N., TOKCAER KESKİN Z., ERMAN M. B., Deniz E.
21st National Biomedical Engineering Meeting (BIYOMUT), İstanbul, Türkiye, 24 Kasım - 26 Aralık 2017, (Tam Metin Bildiri)
2016
2016Characterization of PATZ1 protein structure and its interaction with the tumor suppressor protein p53
Piepoli S., ERMAN M. B., Atilgan C.
41st FEBS Congress on Molecular and Systems Biology for a Better Life, Kusadasi, Türkiye, 3 - 08 Eylül 2016, ss.84, (Özet Bildiri)
2015
2015Innate immune sensors restrict lentiviral gene delivery to human natural killer cells: novel perspectives on the use of viral vectors
Sayitoglu E. C., Duru A. D., Chrobok M., Chiang C., Parlar A., Senturk G. H., et al.
Collaborative Congress of the European-Society-of-Gene-and-Cell-Therapy (ESGCT) and Finnish-Society-of-Gene-Therapy (FSGT), Helsinki, Finlandiya, 17 - 20 Eylül 2015, (Özet Bildiri)
2009
2009PHENOTYPIC AND FUNCTIONAL STUDIES OF NATURAL KILLER (NK) CELL SUBSETS IN β-THALASSEMIA MAJOR PATIENTS
Atasever B., Kuruca S. E., KARAKAŞ Z., ERMAN M. B., ERGEN H. A., Isbir T., et al.
14th Annual Meeting of the European-Hematology-Association, Berlin, Almanya, 4 - 07 Haziran 2009, ss.500-501, (Özet Bildiri)
2009
2009NATURAL KILLER ACTIVITY AND EFFECT OF IL-2 IN PATIENTS WITH β-THALASSEMIA MAJOR
KARAKAŞ Z., Atasever B., Kuruca S. E., ERMAN M. B., ERGEN H. A., Isbir T., et al.
14th Annual Meeting of the European-Hematology-Association, Berlin, Almanya, 4 - 07 Haziran 2009, ss.502, (Özet Bildiri)
2007
2007Coreceptor tuning: IL-7 signals transcriptionally tailor CD8 coreceptor expression in CD8 T cells to the self-specificity of their TCR
Park J., Adoro S., Lucas P. J., Sarafova S. D., Alag A., Doan L. L., et al.
15th Annual Meeting of the International-Cytokine-Society, San-Francisco, Kostarika, 26 - 30 Ekim 2007, ss.32, (Özet Bildiri)
Patent
2024
2024Novel Dna Polymerase Gamma Inhibitor and Uses Thereof
Patent
Tescil Edildi, Buluşun Tescil No: EP18880072.6 , Standart Tescil
2024
2024Yeni dna polimeraz gama inhibitörü ve kullanımları
Patent
Tescil Edildi, Buluşun Tescil No: TR 2024 004765 T4 , Standart Tescil
2018
2018