Screening of new antileukemic agents from essential oils of algae extracts and computational modeling of their interactions with intracellular signaling nodes

Ataseyer-Arslan B., Yilancioglu K., Kalkan Z., Timucin A. C., Gur H., Isik F. B., ...More

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol.83, pp.120-131, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 83
  • Publication Date: 2016
  • Doi Number: 10.1016/j.ejps.2015.12.001
  • Journal Name: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.120-131
  • Keywords: Algae, Essential oils, Leukemia, GC-MS, MOLECULAR-DYNAMICS, INHIBITORS, APOPTOSIS, POTENT, OPTIMIZATION, DESIGN, CELLS
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Microalgae are very rich in bioactive compounds, minerals, polysaccharides, poly-unsaturated fatty acids and vitamins, and these rich constituents make microalgae an important resource for the discovery of new bioactive compounds with applications in biotechnology. In this study, we studied the antileukemic activity of several chosen microalgae species at the molecular level and assessed their potential for drug development. Here we identified Stichococcus bacillaris, Phaeodactylum tricornutum, Microcystis aeruginosa and Nannochloropsis oculata microalgae extracts with possible antileukemic agent potentials. Specifically we studied the effects of these extracts on intracellular signal nodes and apoptotic pathways. We characterized the composition of essential oils of these fifteen different algae extracts using gas chromatography-mass spectrometry (GC-MS). Finally, to identify potential molecular targets causing the phenotypic changes in leukemic cell lines, we docked a selected group of these essential oils to several key intracellular proteins. According to results of rank score algorithm, five of these essential oils analyzed might be considered as in silico plausible candidates to be used as antileukemic agents. (C) 2015 Elsevier B.V. All rights reserved.