Metrikler
Yayın
43
Açık Erişim
3
BM Sürdürülebilir Kalkınma Amaçları
Eğitim Bilgileri
2015 - 2017
2015 - 2017Post Doktora
Sabancı Üniversitesi, Graduate School of Engineering and Natural Sciences, Biological Sciences and Bioengineering Program, Türkiye
2008 - 2015
2008 - 2015Doktora
Sabancı Üniversitesi, Graduate School of Engineering and Natural Sciences, Biological Sciences and Bioengineering Program, Türkiye
2007 - 2008
2007 - 2008Yüksek Lisans
Columbia University in the City of New York, College of Physicians and Surgeons, Institute of Human Nutrition, Amerika Birleşik Devletleri
2003 - 2007
2003 - 2007Lisans
Sabancı Üniversitesi, Faculty of Engineering and Natural Sciences, Biological Sciences and Bioengineering Program, Türkiye
Yaptığı Tezler
2015
2015Doktora
IDENTIFICATION OF SIRT1 AS A NOVEL REGULATOR OF NFAT5 DEPENDENT ALDOSE REDUCTASE EXPRESSION UNDER OSMOTIC STRESS
Sabancı Üniversitesi, Graduate School of Engineering and Natural Sciences, Biological Sciences and Bioengineering Program
2008
2008Yüksek Lisans
Modulation of Cell Death by Aldose Reductase Pathway in Diabetic Hearts
Columbia University in the City of New York, College of Physicians and Surgeons, Institute of Human Nutrition
Araştırma Alanları
Moleküler Biyokimya
Yapısal Biyoloji
Biyolojik Modelleme
Kanser Moleküler Biyolojisi
Protein Mühendisliği
Akademik Ünvanlar / Görevler
2022 - Devam Ediyor
2022 - Devam EdiyorDoç. Dr.
Acıbadem Mehmet Ali Aydınlar Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Moleküler Biyoloji ve Genetik Bölümü
2021 - 2022
2021 - 2022Dr. Öğr. Üyesi
Acıbadem Mehmet Ali Aydınlar Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Moleküler Biyoloji ve Genetik Bölümü
SCI, SSCI ve AHCI İndekslerine Giren Dergilerde Yayınlanan Makaleler
2025
20251. Molecular Consequences of CCN6 Variants Encoding WISP3 in Progressive Pseudorheumatoid Dysplasia
Guven Tasbicen G., Tufan A., Savsar B., Bulbul A. A., Tonbul Z., Guzel E., et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , cilt.26, ss.1-33, 2025 (SCI-Expanded)
2025
20252. Peptide-Based Regulation of TNF-α-Mediated Cytotoxicity
TEMUR B. Z., TİMUÇİN V. C., ATİK A. E., KOCAGÖZ Z. T., CAN Ö.
Biomolecules
, cilt.15, sa.4, 2025 (SCI-Expanded)
2025
20253. Experimental and Computational Insights into the Structural Dynamics of the Fc Fragment of IgG1 Subtype from Biosimilar VEGF-Trap
Destan E., Turkut E., Aldeniz A., Kang J., Tosha T., Yabashi M., et al.
SMALL STRUCTURES , ss.1-14, 2025 (SCI-Expanded)
2024
20244. A rare case of uncharacterized autoinflammatory disease: Patient carrying variations in NLRP3 and TNFRSF1A genes.
Kilinc O. C., Gayibova K., Onen M. O., Onat U. I., Bülbül A. A., Timucin A. C., et al.
American journal of medical genetics. Part A
, cilt.194, sa.10, 2024 (SCI-Expanded)
2024
20245. Structure based computational RNA design towards MafA transcriptional repressor implicated in multiple myeloma
Akdeniz G. Y., Timuçin A. C.
JOURNAL OF MOLECULAR GRAPHICS AND MODELLING , cilt.132, ss.1-17, 2024 (SCI-Expanded)
2024
20246. Var3PPred: variant prediction based on 3-D structure and sequence analyses of protein-protein interactions on autoinflammatory diseases
Bülbül A. A., TİMUÇİN E., TİMUÇİN A. C., SEZERMAN O. U., TAHİR TURANLI E.
PeerJ
, cilt.12, sa.5, 2024 (SCI-Expanded)
2023
20237. Computational completion of the Aurora interaction region of N-Myc in the Aurora a kinase complex
Altiner P., Çınaroğlu S. S., Timuçin A. C., Timucin E.
SCIENTIFIC REPORTS
, cilt.13, sa.1, 2023 (SCI-Expanded)
2023
20238. Detection of a rare variant in PSTPIP1 through three generations in a family with an initial diagnosis of FMF/MKD-overlapping phenotype
Özkılınç Önen M., Onat U. İ., Uğurlu S., Timuçin A. C., Öz Arslan D., Everest E., et al.
RHEUMATOLOGY
, sa.9, ss.3188-3196, 2023 (SCI-Expanded)
2022
20229. Modeling and dynamical analysis of the full-length structure of factor XII with zinc.
Kılınç E., Can Timucin A. C., Selim Cinaroglu S., Timucin E.
Journal of molecular modeling
, cilt.28, sa.5, ss.129, 2022 (SCI-Expanded)
2022
202210. Toward Compilation of Balanced Protein Stability Data Sets: Flattening the Delta Delta G Curve through Systematic Enrichment
Kebabci N., TİMUÇİN A. C., TİMUÇİN E.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
, cilt.62, sa.5, ss.1345-1355, 2022 (SCI-Expanded)
2021
202111. Bridging the Bridging Imidazolate in the Bimetallic Center of the Cu/Zn SOD1 and ALS
TİMUÇİN A. C., Cinaroglu S. S., SEZERMAN O. U., TİMUÇİN E.
FRONTIERS IN CHEMISTRY
, cilt.9, 2021 (SCI-Expanded)
2021
202112. Structure based peptide design, molecular dynamics and MM-PBSA studies for targeting C terminal dimerization of NFAT5 DNA binding domain
Timucin A. C.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING
, cilt.103, 2021 (SCI-Expanded)
2020
202013. The sex-dependent anti-depressant-like effects of zeatin in rat behavioral despair model as a candidate A2A receptor ligand
Oz P., Timucin A. C., Teomete S., Akpunar F., Tufanc C., Ogur D., et al.
NEUROSCIENCE LETTERS
, cilt.734, 2020 (SCI-Expanded)
2020
202014. Immunotherapy approaches on innate immunity for SARS-Cov-2
Arslan B. A., Timucin A. C.
ACTA VIROLOGICA
, cilt.64, sa.4, ss.389-395, 2020 (SCI-Expanded)
2019
201915. Selective targeting of antiapoptotic BCL-2 proteins in cancer
Timucin A. C., Basaga H., Kutuk O.
MEDICINAL RESEARCH REVIEWS
, cilt.39, sa.1, ss.146-175, 2019 (SCI-Expanded)
2017
201716. Pro-apoptotic effects of lipid oxidation products: HNE at the crossroads of NF-kappa B pathway and anti-apoptotic Bcl-2
Timucin A. C., Basaga H.
FREE RADICAL BIOLOGY AND MEDICINE
, cilt.111, ss.209-218, 2017 (SCI-Expanded)
2016
201617. AMP-Activated Protein Kinase Couples 3-Bromopyruvate-Induced Energy Depletion to Apoptosis via Activation of FoxO3a and Upregulation of Proapoptotic Bcl-2 Proteins
Bodur C., Karakas B., Timucin A. C., Tezil T., Basaga H.
MOLECULAR CARCINOGENESIS
, cilt.55, sa.11, ss.1584-1597, 2016 (SCI-Expanded)
2016
201618. SIRT6 Is a Positive Regulator of Aldose Reductase Expression in U937 and HeLa cells under Osmotic Stress: In Vitro and In Silico Insights
Timucin A. C., Basaga H.
PLOS ONE
, cilt.11, sa.8, 2016 (SCI-Expanded)
2016
201619. Screening of new antileukemic agents from essential oils of algae extracts and computational modeling of their interactions with intracellular signaling nodes
Ataseyer-Arslan B., Yilancioglu K., Kalkan Z., Timucin A. C., Gur H., Isik F. B., et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
, ss.120-131, 2016 (SCI-Expanded)
2015
201520. SIRT1 contributes to aldose reductase expression through modulating NFAT5 under osmotic stress: In vitro and in silico insights
Timucin A. C., Bodur C., Basaga H.
CELLULAR SIGNALLING
, cilt.27, sa.11, ss.2160-2172, 2015 (SCI-Expanded)
2012
201221. ANTIBODY ARRAY-BASED IMMUNOSENSOR FOR DETECTING CARDIOVASCULAR DISEASE RISK MARKERS
Timucin C., Gul O., Kutuk O., Basaga H.
JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY
, cilt.33, sa.3, ss.275-290, 2012 (SCI-Expanded)
2008
200822. Identification of biomarkers for the antiangiogenic and antitumour activity of the superoxide dismutase 1 (SOD1) inhibitor tetrathiomolybdate (ATN-224)
Donate F., Juarez J. C., Burnett M. E., Manuia M. M., Guan X., Shaw D. E., et al.
BRITISH JOURNAL OF CANCER
, cilt.98, sa.4, ss.776-783, 2008 (SCI-Expanded)
Diğer Dergilerde Yayınlanan Makaleler
2024
20241. Experimental and Computational Insights into the Structural Dynamics of the Fc Fragment of IgG1 Subtype from Biosimilar VEGF-Trap
Destan E., Turkut E., Aldeniz A., Kang J., Tosha T., Yabashi M., et al.
BIORXIV , sa.-, ss.1-28, 2024 (Hakemsiz Dergi)
2022
20222. Selective cytotoxicity of chemical composition of Spirulina platensis extract in endometrial cells: In vitro and in silico approach
Atasever Arslan B., Yılancıoğlu K., Timuçin A. C., Kalkan Z., Kuşoğlu Gültekin S., Çetiner S.
KSU TARIM VE DOGA DERGISI-KSU JOURNAL OF AGRICULTURE AND NATURE , cilt.0, 2022 (Hakemli Dergi)
2021
20213. Towards Compilation of Balanced Protein Stability Datasets: Flattening the ΔΔG Curve through Systematic Under-sampling
Timuçin A. C., Timuçin E.
BIORXIV , cilt.0, ss.1-31, 2021 (Hakemsiz Dergi)
2021
20214. Molecular Dynamics and MM-PBSA Studies for Deciphering Molecular Interactions of Valproic Acid with CYP2C9 Mutants F114L and I207T
Timuçin A. C.
Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi , cilt.25, ss.64-73, 2021 (Hakemli Dergi)
2021
20215. Conserved Amino Acids in HCoV-HKU1 and SARS-Cov2 at RNA-dependent RNA Polymerase (RdRp) Motifs
Timuçin A. C.
Anatolian Journal of Biology
, cilt.2, ss.17-24, 2021 (Hakemli Dergi)
2020
20206. Computational Modeling of Trans-Zeatin as a Novel Target of Adenosine A2A Receptor: Insights into Molecular Interactions
Timuçin A. C.
The Journal of Neurobehavioral Sciences , cilt.7, ss.118-129, 2020 (Hakemli Dergi)
Hakemli Bilimsel Toplantılarda Yayımlanmış Bildiriler
2025
20251. Towards mono-functionalized phthalocyanines designed to be anchored at the active site of enzymes
Alaghaa H. Z., Timuçin A. C., Timuçin E., Dumoulin F., Ricoux R., İşçi Ü.
36th National Chemistry Congress (UKK2025), Van, Türkiye, 31 Ağustos - 03 Eylül 2025, ss.1, (Özet Bildiri)
2025
20252. Molecular Docking, Weak Interaction, and Molecular Dynamics Studies of Novel Chalcone-Based Structures as Potential Inhibitors of Tubulin and EGFR for Cancer Therapy
Yıldırım Akdeniz G., Timuçin A. C., Başağa S. H.
33rd ISMB (Intelligent Systems for Molecular Biology) Conference/European Conference on Computational Biology (the 24th Annual Conference), Liverpool, İngiltere, 20 - 24 Temmuz 2025, ss.1, (Özet Bildiri)
2025
20253. Impact of LAMA5 Variants on Immune Cell Infiltration using 2D Blood Brain Barrier Culture Model of Multiple Sclerosis
Voyvoda U., Karisik S. N., Reda M. D., Efe H., Cotuk ., Cakici B., et al.
6th International Molecular Immunology and Immunogenetics Congress (MIMIC-VI), İstanbul, Türkiye, 28 - 30 Nisan 2025, ss.1-2, (Özet Bildiri)
2025
20254. Discovery of Peptide-based Inhibitor Targeting the Human IL18:IL18Rα Complex
Düvenci Z. Ş., Timuçin A. C., Timuçin E.
6th INTERNATIONAL MOLECULAR IMMUNOLOGY & IMMUNOGENETICS CONGRESS (MIMIC-VI), İstanbul, Türkiye, 28 Nisan - 30 Mayıs 2025, ss.1-2, (Özet Bildiri)
2024
20245. Discovery of Peptide-based Inhibitor Targeting the Human IL18:IL18Rα Complex
Düvenci Z. Ş., Timuçin A. C., Timuçin E.
17th The International Symposium on Health Informatics and Bioinformatics (HIBIT), İstanbul, Türkiye, 18 - 20 Aralık 2024, ss.1-2, (Özet Bildiri)
2024
20246. Novel Approaches in Rational Peptide Design for Recognition of FABP3 and Myoglobin in Cardiac Biosensors
Karadeniz K. B., Şentürk B., Timuçin A. C., Kocagöz Z. T., Camadan E., Can Ö.
ODTU MEMS Center 3rd BioMEMS and Microfluidic Technologies Workshop, Ankara, Türkiye, 10 - 11 Haziran 2024, (Yayınlanmadı)
2024
20247. A rare case of uncharacterised autoinflammatory disease: patient carrying variations in NLRP3 and TNFRSF1A genes
Kılınç Ö. C., Gayibova K., Durucan İ., Özkılınç Önen M., Onat U. İ., Bülbül A., et al.
European Congress of Rheumatology, Vienna, Avusturya, 12 - 15 Haziran 2024, (Yayınlanmadı)
2023
20238. Genetic and Functional Activity Analyses of ADA2 in Patients with Deficiency of Adenosine Deaminase 2
Everest E., Ozkilinc Onen M., Demirci T., Timuçin A. C., Sahin S., Kasapcopur O., et al.
American Society of Human Genetics Annual Meeting, Washington, Amerika Birleşik Devletleri, 1 - 05 Kasım 2023, ss.258, (Özet Bildiri)
2023
20239. Classification of Variants in Systemic Autoinflammatory Diseases using 3D Structures and Protein-protein Interactions
Bülbül A., Timuçin E., Timuçin A. C., Sezerman O. U., Tahir Turanlı E.
American Society of Human Genetics Annual Meeting , Washington, Amerika Birleşik Devletleri, 1 - 05 Kasım 2023, ss.516, (Özet Bildiri)
2023
202310. Computational Design of RNA Based Modulators Targeting Maf-A protein for Multiple Myolema
Yıldırım Akdeniz G., Başağa S. H., Timuçin A. C.
Intelligient Systems for Molecular Biology/European Conference on Computational Biology 2023, Lyon, Fransa, 23 - 27 Temmuz 2023, (Yayınlanmadı)
2021
202111. Transkripsiyon faktörlerinin hedeflenmesi için yapı tabanlı peptit tasarımı, moleküler dinamik ve MM-PBSA çalışmaları
Timuçin A. C.
10.Ulusal Moleküler Biyoloji ve Biyoteknoloji Kongresi, İstanbul, Türkiye, 17 - 19 Aralık 2021, (Yayınlanmadı)
2021
202112. Computational design of a peptide targeting homodimerization of BACH2 BTB domain using molecular dynamics and MM-PBSA studies
Timuçin A. C.
4th International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2021), Ankara, Türkiye, 24 - 26 Kasım 2021, ss.1-2, (Özet Bildiri)
2021
202113. Molecular dynamics and MM-PBSA based relative binding free energy prediction studies for identification of novel amino acids and nucleic acids governing the interaction between transcription factor NFAT5 and its target consensus DNA sequence
Timuçin A. C.
10th International Molecular Biology and Biotechnology Congress, İstanbul, Türkiye, 4 - 08 Ekim 2021, ss.1, (Özet Bildiri)
2007
200714. Early biomarkers for the anti-angiogenic and anti-thmor activity of the superoxide dismutase 1 (SOD1) inhibitor tetrathiomolybdate
Braunstein M. J., Smith E., Timucin C., Donate F., Juarez J. C., Burnett M., et al.
49th Annual Meeting of the American-Society-of-Hematology, Georgia, Amerika Birleşik Devletleri, 8 - 11 Aralık 2007, cilt.110, (Özet Bildiri)
2006
200615. Differential effects of Hsp70 inhibition within the tumor and microenvironment in multiple myeloma.
Braunstein M. J., Liu N., Klueppelberg U., Scott C., Behrman S., Tamucin C., et al.
48th Annual Meeting of the American-Society-of-Hematology, Florida, Amerika Birleşik Devletleri, 9 - 12 Aralık 2006, cilt.108, (Özet Bildiri)
Desteklenen Projeler
2024 - 2027
2024 - 2027Phthalozymes: new artificial metalloenzymes for concomitant photocatalytic hydrogen production and CO2 reduction
TÜBİTAK Uluslararası İkili İşbirliği Projesi , 2509 - Fransa Dışişleri Bakanlığı ile Bosphorus Programı
Timuçin A. C., İşci Ü.(Yürütücü), Dumoulın F., Timuçin E.
2023 - 2026
2023 - 2026Investigation of functional roles of LAMA5 gene variants identified in a cohort of Turkish multiple sclerosis families on the disease pathophysiology
TÜBİTAK Projesi , 1001 - Bilimsel ve Teknolojik Araştırma Projelerini Destekleme Programı
Tahir Turanlı E. (Yürütücü), Onat U. İ., Timuçin A. C.
2022 - 2026
2022 - 2026Detection and monitorization of cardiovascular disease parameter through MEMS structured sensor systems (KARMEMS)
TÜBİTAK Projesi , 1004 – Mükemmeliyet Merkezi Destek Programı FAZ II
Timuçin A. C., Gürol İ.(Yürütücü), Can Ö., Kocagöz Z. T.
2022 - 2026
2022 - 2026MAESTRO - Micro Medical Technologies Platform
TÜBİTAK Projesi , 1004 – Mükemmeliyet Merkezi Destek Programı FAZ II
Timuçin A. C., Külah H., Gürol İ.(Yürütücü), Can Ö., Kocagöz Z. T.
2021 - 2025
2021 - 2025Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases (BenBedPhar)
TÜBİTAK - AB COST Projesi
Timuçin A. C., Cuadrado A.
2022 - 2024
2022 - 2024Rational design of peptides targeting BTB domain homodimerization of BACH2, a nuclear suppressor NRF2 transcription factor: Complementary in silico and in vitro approaches
TÜBİTAK - AB COST Projesi
Timuçin A. C. (Yürütücü), Timuçin E., Başağa S. H.
2022 - 2024
2022 - 2024Peptide-based Inhibitor Discovery Targeting the Human IL18:IL18Rα Complex
TÜBİTAK Projesi , 1001 - Bilimsel ve Teknolojik Araştırma Projelerini Destekleme Programı
Timuçin A. C. (Yürütücü), Timuçin E., Belkaya S.
2021 - 2023
2021 - 2023SEMI-RATIONAL PEPTIDE DESIGN TARGETING AURORA A/N-MYC COMPLEX AND EXPERIMENTAL VALIDATIONS
TÜBİTAK Projesi , 1001 - Bilimsel ve Teknolojik Araştırma Projelerini Destekleme Programı
Timuçin A. C., Timuçin E. (Yürütücü)
2019 - 2020
2019 - 2020In silico development of peptide-based inhibitor candidate molecules targeting NFAT5 dimerization domain
TÜBİTAK Projesi , 1002 - Hızlı Destek Programı
Timuçin A. C. (Yürütücü)
2019 - 2020
2019 - 2020In silico peptide design and molecular analyses for inhibiting dimerization of K-RAS
TÜBİTAK Projesi , 2209-A - Üniversite Öğrencileri Araştırma Projeleri Destekleme Programı
Timuçin A. C., Sözer B.(Yürütücü)
2016 - 2019
2016 - 2019RESEARCH AND DEVELOPMENT OF NANOPARTICLE AND PHOTODYNAMIC THERAPHY BASED ADVANCED THERANOSTIC APPLICATIONS FOR CANCER
TÜBİTAK Projesi , 1509 - TÜBİTAK Uluslararası Sanayi Ar-Ge Projeleri Destekleme Programı
Timuçin A. C., Başağa S. H.(Yürütücü)
2016 - 2019
2016 - 2019Advanced theranostic approach in cancer combining photodynamic therapy and nanoparticles
TÜBİTAK Uluslararası Çoklu İşbirliği Projesi , ERA.NET Projesi
Timuçin A. C., Başağa S. H.(Yürütücü)
2017 - 2017
2017 - 2017