Asst. Prof. Zeynep TOKCAER KESKİN

Education Information

2005 - 2010

Doctorate

Ihsan Dogramaci Bilkent University, Instıtute Of Engıneerıng And Natural Scıences, Molecular Biology and Genetics, Turkey

2001 - 2003

Post Graduate

Middle East Technical University, Graduate School Of Natural And Applied Sciences, Graduate School Of Natural And Applied Sciences, Turkey

1997 - 2001

Under Graduate

Middle East Technical University, Faculty Of Arts And Sciences, Department Of Biology, Turkey

Dissertations

2010

Doctorate

Contribution of mesenchymal stem cells in cell based therapies

Ihsan Dogramaci Bilkent University, Instıtute Of Engıneerıng And Natural Scıences

2003

Post Graduate

Response surface optimization of Bacillus thuringiensis israelensis fermentation

Middle East Technical University, Graduate School Of Natural And Applied Sciences

Foreign Languages

C2 Mastery

English

Certificates, Courses and Trainings

2021

EJP WORKSHOP: Rare Disease Biobanks: Roles in Research Networks and International Collaborations

Health&Medicine

Hacettepe Üniversitesi

Research Areas

Health Sciences, Natural Sciences

Academic Titles / Tasks

2015 - Continues

Assistant Professor

Acibadem Mehmet Ali Aydinlar University, Faculty of Arts and Sciences, Molecular Biology and Genetics

2013 - 2015

Research Assistant PhD

Ankara University, Ankara Faculty Of Medıcıne, Temel Tıp Bilimleri

2012 - 2013

Research Assistant PhD

New York University, School of Medicine, Department of Microbiology

2011 - 2012

Research Assistant PhD

New York University, School of Medicine, Department of Neurosurgery

Managerial Experience

2020 - Continues

Head of Department

Acibadem Mehmet Ali Aydinlar University, Graduate School of Natural and Applied Sciences , Molecular and Translational Biomedicine Program with Thesis

2019 - Continues

Bölüm Stratejik Plan Komisyonu Üyesi

Acibadem Mehmet Ali Aydinlar University, Faculty of Arts and Sciences, Molecular Biology and Genetics

2017 - Continues

Staj Koordinatörü

Acibadem Mehmet Ali Aydinlar University, Faculty of Arts and Sciences, Molecular Biology and Genetics

2020 - 2021

Head of Department

Acibadem Mehmet Ali Aydinlar University, Faculty Of Arts And Sciences, Molecular Biology And Genetics

2018 - 2020

Birim Kalite Komisyonu Üyesi

Acibadem Mehmet Ali Aydinlar University, Faculty of Arts and Sciences, Molecular Biology and Genetics

Non Academic Experience

2004 - 2005

Clinical Research Associate

Company, Optimum CRO, Optimum CRO

Courses

Post Graduate

Molecular and Translational Biomedicine

Post Graduate

Seminar

Under Graduate

Senior Project

Under Graduate

Stem Cell and Therapy

Under Graduate

Developmental Biology

Under Graduate

Seminar

Post Graduate

Introduction to molecular and translational Biomedicine

Under Graduate

Senior Project

Under Graduate

Genetic Engineering and Biotechnology

Under Graduate

Summer Practice

Under Graduate

Genetics

Post Graduate

Stem Cell and Regenerative Applications

Post Graduate

Research Techniques and Ethics in Natural Sciences

Post Graduate

Introduction to Molecular and Translational Biomedicine

Under Graduate

Research Techniques in Biochemistry and Genetics

Advising Theses

Continues

Post Graduate

Characterization Of Umbilical Cord Derived Mesenchymal Stem Cell Spheroids Embedded Into Fibrin Matrix Before Regenerative Use

Tokcaer Keskin Z.

R.Vural(Student)

2019

Post Graduate

Investigating the Effects of 5,10-Methylenetetrahydrofolate Reductase C677T Polymorphism on Human Mesenchymal Stem Cells by Using CRISPR/Cas9 System as a Gene Editing Tool

Tokcaer Keskin Z. , Deniz E. (Co-Consultant)

B.TALUĞ(Student)

Designed Lessons

Under Graduate

Stem Cell and Regenerative Applications

Tokcaer Keskin Z.

Post Graduate

Introduction to Molecular and Translational Biomedicine

Tokcaer Keskin Z. , Deniz E.

Under Graduate

Stem Cell and Therapy

Tokcaer Keskin Z.

Post Graduate

Molecular and Translational Biomedicine

Tokcaer Keskin Z. , Deniz E.

Under Graduate

Research Techniques in Molecular Biology and Biochemistry

Tokcaer Keskin Z.

Under Graduate

Developmental Biology

Tokcaer Keskin Z. , Deniz E.

Under Graduate

Genetic Engineering and Biotechnology

Tokcaer Keskin Z.

Under Graduate

Genetics

Tokcaer Keskin Z.

Taught Courses And Trainings

2021 - 2021

Winter Science Camp for Highschool Students

Continuing Education Center - Certificate Program

Akın A. , Argunşah H. , Erdoğan S. B. , Kitapçıoğlu D. , Deniz E. , Keskin Toklu N. , et al.

2019 - 2019

Summer Science School for Highschool Students

Academic Units - Training

Öktem Okullu S. , Mozioğlu E. , Akın A. , Çelebi A. R. C. , Kitapçıoğlu D. , Deniz E. , et al.

2018 - 2018

Eğiticinin Eğitimi

Academic Units - Training

Tokcaer Keskin Z. , Deniz E.

Designed Programs

2017 - Continues

Molecular and Translational Biomedicine

Undergraduate Double Major

Deniz E. , Tokcaer Keskin Z. , Yakıcıer M. C.

Articles Published in Journals That Entered SCI, SSCI and AHCI Indexes

2019

Induced Pluripotent Stem Cells in Disease Modelling and Regeneration.

Talug B., Tokcaer-Keskin Z.

Advances in experimental medicine and biology, vol.1144, pp.91-99, 2019 (Journal Indexed in SCI)

2018

Increased free Zn2+ correlates induction of sarco(endo)plasmic reticulum stress via altered expression levels of Zn2+-transporters in heart failure

OLĞAR Y., DURAK BATIGÜN A., Tuncay E., Bitirim C. V. , ÖZÇINAR E., İNAN M. B. , et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol.22, no.3, pp.1944-1956, 2018 (Journal Indexed in SCI)

2015

Comparative FAIRE-seq Analysis Reveals Distinguishing Features of the Chromatin Structure of Ground State- and Primed-Pluripotent Cells

Murtha M., Strino F., Tokcaer-Keskin Z. , Bayin N. S. , Shalabi D., Xi X., et al.

STEM CELLS, vol.33, no.2, pp.378-391, 2015 (Journal Indexed in SCI)

2014

Di-peptidyl peptidase-4 inhibitor sitagliptin protects vascular function in metabolic syndrome: possible role of epigenetic regulation.

Cicek F., Tokcaer-Keskin Z. , Ozcinar E., Bozkus Y., Akcali K., Turan B.

Molecular biology reports, vol.41, pp.4853-63, 2014 (Journal Indexed in SCI)

2014

FIREWACh: high-throughput functional detection of transcriptional regulatory modules in mammalian cells

Murtha M., Tokcaer-Keskin Z. , Tang Z., Strino F., Chen X., Wang Y., et al.

NATURE METHODS, vol.11, no.5, pp.559-565, 2014 (Journal Indexed in SCI)

2012

The Effect of Estrogen on Bone Marrow-Derived Rat Mesenchymal Stem Cell Maintenance: Inhibiting Apoptosis Through the Expression of Bcl-x(L) and Bcl-2

Ayaloglu-Butun F., Terzioglu-Kara E., Tokcaer-Keskin Z. , Akcali K. C.

STEM CELL REVIEWS AND REPORTS, vol.8, no.2, pp.393-401, 2012 (Journal Indexed in SCI)

2010

The Effect of Telomerase Template Antagonist GRN163L on Bone-Marrow-Derived Rat Mesenchymal Stem Cells is Reversible and Associated with Altered Expression of Cyclin d1, cdk4 and cdk6

Tokcaer-Keskin Z. , DİKMEN Z. G. , Ayaloglu-Butun F., Gultekin S., Gryaznov S. M. , Akcali K. C.

STEM CELL REVIEWS AND REPORTS, vol.6, no.2, pp.224-233, 2010 (Journal Indexed in SCI)

2009

Timing of induction of cardiomyocyte differentiation for in vitro cultured mesenchymal stem cells: a perspective for emergencies

Tokcaer-Keskin Z. , Akar A. R. , Ayaloglu-Butun F., Terzioglu-Kara E., Durdu S., Ozyurda U., et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, vol.87, no.2, pp.143-150, 2009 (Journal Indexed in SCI)

2007

Cloning and expression profile of FLT3 gene during progenitor cell-dependent liver regeneration

Aydin I. T. , Tokcaer Z. , Dalgic A., Konu O., Akcali K. C.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol.22, no.12, pp.2181-2188, 2007 (Journal Indexed in SCI)

2006

Response surface optimization of antidipteran delta-endotoxin production by Bacillus thuringiensis subsp israelensis HD 500

Tokcaer Z. , Bayraktar E., Mehmetoglu U., Ozcengiz G., Alaeddinoglu N.

PROCESS BIOCHEMISTRY, vol.41, no.2, pp.350-355, 2006 (Journal Indexed in SCI)

Articles Published in Other Journals

2019

ADMINISTRATION OF BONE MARROW DERIVED MESENCHYMAL STEM CELLS MODULATE TLR EXPRESSION DURING LIVER REGENERATION

Koçak H., Tokcaer Keskin Z. , İnsal B., Gürsel İ., Akçalı K. C.

Trakya University Journal of Natural Sciences, vol.20, no.1, pp.1-10, 2019 (Journal Indexed in ESCI)

Refereed Congress / Symposium Publications in Proceedings

2021

Long Non-Coding RNA DANCR Controls The Cellular Mechanism Upon DNA Damage Induction

Baran G., Kılıç İ. B. , Keskin Toklu N. , Tokcaer Keskin Z. , Deniz E.

8th Multidisciplinary Cancer Research Congress, 16 - 17 January 2021, pp.148

2021

Identifying Novel Gene Products Conferring Drug Resistance In Cancer Chemotherapy

Deniz E. , Kılıç İ. B. , Baran G., Yılmaz Z. H. , Nalbant N., Kavaklıoğlu B., et al.

8th Multidisciplinary Cancer Research Congress, 16 - 17 January 2021, pp.93

2019

Identification of resistance mechanisms against cytotoxic drugs using genome-wide CRISPR/Cas9 Knock-out screening approach

Yılmaz Z. H. , Tokcaer Keskin Z. , Keskin Toklu N. , Deniz E.

Seventh International Congress of the Molecular Biology Association of Turkey, İstanbul, Turkey, 27 - 29 September 2019, pp.172

2019

A long noncoding RNA repressed by DNA damage mediates cell survival and proliferation

Baran G., Kılıç I. B. , Keskin Toklu N. , Tokcaer Keskin Z. , Deniz E.

Seventh International Congress of the Molecular Biology Association of Turkey, İstanbul, Turkey, 27 - 29 September 2019, pp.83

2019

Investigating the Effects of 5,10-Methylenetetrahydrofolate Reductase C677T Polymorphism on Mesenchymal Stem Cells by Using CRISPR/Cas9 System as a Gene Editing Tool

Taluğ B., Deniz E. , Tokcaer Keskin Z.

Organelle Biogenesis and Function in Cell physiology and in Disease conference, İstanbul, Turkey, 27 - 28 May 2019, pp.52

2019

A long noncoding RNA repressed by DNA damage mediates cell survival and proliferation

Baran G., Keskin Toklu N. , Tokcaer Keskin Z. , Deniz E.

Organelle Biogenesis and Function in Cell physiology and in Disease conference, İstanbul, Turkey, 27 - 28 May 2019, pp.55

2019

Genome-wide screening of resistance mechanisms against cytotoxic drugs

Yılmaz Z. H. , Tokcaer Keskin Z. , Keskin Toklu N. , Deniz E.

Organelle Biogenesis and Function in Cell physiology and in Disease conference, İstanbul, Turkey, 27 - 28 May 2019, pp.65

2019

Investigating the Effects of 5,10-Methylenetetrahydrofolate Reductase C677T Polymorphism on Mesenchymal Stem Cells by Using CRISPR/Cas9 System as a Gene Editing Tool

Taluğ B., Deniz E. , Tokcaer Keskin Z.

International Molecular Medicine Symposium by the Bosphorus, İstanbul, Turkey, 16 - 18 May 2019, pp.74

2019

Genome-wide screening of resistance mechanisms against cytotoxic drugs

Yılmaz Z. H. , Tokcaer Keskin Z. , Keskin Toklu N. , Deniz E.

International Molecular Medicine Symposium by the Bosphorus, İstanbul, Turkey, 16 - 18 May 2019, pp.44

2019

A long noncoding RNA repressed by DNA damage mediates cell survival and proliferation

Baran G., Keskin Toklu N. , Tokcaer Keskin Z. , Deniz E.

International Molecular Medicine Symposium by the Bosphorus, İstanbul, Turkey, 16 - 18 May 2019, pp.45

2017

Investigating the Effects of 5,10-Methylenetetrahydrofolate Reductase C677T Polymophism on Mesenchymal Stem Cells by Using CRISPR/Cas9 System as a Gene Editing Tool

Taluğ B., Deniz E. , Tokcaer Keskin Z.

Fifth International Congress of the Molecular Biology Association of Turkey, İstanbul, Turkey, 8 - 10 September 2017, pp.187

2017

The Role of Long Noncoding RNA DANCR in the DNA Damage Response

Baran G., Taluğ B., Keskin N. , Tokcaer Keskin Z. , Erman M. B. , Deniz E.

Fifth International Congress of the Molecular Biology Association of Turkey, İstanbul, Turkey, 8 - 10 September 2017, pp.70

2014

NO PATHWAY AND EPIGENETIC ALTERATIONS MAY BE NEW POSSIBLE TARGETS FOR METABOLIC SYNDROME

Çiçek F., Tokcaer Keskin Z. , Akçalı K. C. , Turan B.

EUROPEAN SECTION MEETING OF THE INTERNATIONAL ACADEMY OF CARDIOVASCULAR SCIENCES, Zalaegerszeg, Hungary, 08 October 2014, pp.1

2010

FLT3 MAY FUNCTION AS A LINK BETWEEN LIVER REGENERATION AND HEPATOCELLULAR CARCINOGENESIS

Bayın N. S. , Tokcaer Keskin Z. , Acun T., Yakıcıer M. C. , Akçalı K. C.

EASL SIGNALING IN THE LIVER, Amsterdam, Netherlands, 18 February 2010

2009

THE IN VITRO EFFECTS OF TELOMERASE INHIBITION ON BONE MARROW DERIVED RAT MESENCHYMAL STEM CELLS

Tokcaer Keskin Z. , Dikmen Z. G. , Gryaznov S., Akçalı K. C.

INTERNATIONAL SOCIETY FOR STEM CELL RESEARCH 7TH ANNUAL MEETING, Barcelona, Spain, 08 July 2009, pp.7

Books & Book Chapters

2013

Genetic Identification of Human Embryonic Stem Cell-Derived Neural Cell Types Using Bacterial Artificial Chromosomes

Tokcaer Keskin Z. , Placantonakis D. G.

in: Stem Cells and Cancer Stem Cells, M. A. Hayat, Editor, Springer, London/Berlin , Dordrecht, pp.125-136, 2013

2012

Mesenchymal Stem Cells: Possibilities of New Treatment Options

Tokcaer Keskin Z. , Koçak H., Gürsel İ., Akçalı K. C.

in: Adult and Embryonic Stem Cells, Kursad Turksen, Editor, Springer, London/Berlin , New-York, pp.59-67, 2012

Supported Projects

2019 - 2022

Linagliptin ve Empagliflozin Tedavilerinin STZ-Diabetik Sıçan Kalbinde Olası Etkilerinin miRNA'lar Üzerinden Karşılaştırmalı Olarak Değerlendirilmesi

TUBITAK Project

İnan E. A. (Executive), Tokcaer Keskin Z. , Terzi O. S.

2017 - 2021

Genome-Wide Screening With CRISPR/Cas9 and Modelling of Resistance Mechanims Developed Against Cytotoxic Drugs in Cancer Treatment

TUBITAK Project

Deniz E. (Executive) , Tokcaer Keskin Z. , Yakıcıer M. C. , Erman M. B.

2019 - 2020

İnsan Mezenkimal Kök Hücrelerinde 5,10- Metilentetrahidrofolat redüktaz C677T Polimorfizm Etkisinin Farklılaşma Üzerine Etkisinin İncelenmesi

TUBITAK Project

(Project Abstract)

Tokcaer Keskin Z. (Executive)

2018 - 2019

Zn2+-taşıyıcısı ZnT6'nın hücre iç serbest Zn2+ düzenlenmesindeki rolünün H9c2 hücrelerinde hiperglisemik koşullarda incelenmesi

TUBITAK Project

Tokcaer Keskin Z. , Tuncay E.(Executive)

2017 - 2018

İnsan Mezenkimal Kök Hücrelerinde CRISPR/Cas9 Genom Düzenleme Yönetimi ile 5,10-Metilentetrahidrofolat redüktaz C677T Polimorfizm Etkisinin Araştırılması

Project Supported by Higher Education Institutions

Tokcaer Keskin Z. (Executive)

2016 - 2017

Kanagliflozinin İnsan Uyarılmış Pluripotent Kök Hücrelerinden Farklılaştırılan Kardiyomiyositler Kullanılarak İnsan Kardiyomiyositlerindeki Etkisinin Belirlenmesi

Project Supported by Higher Education Institutions

Tokcaer Keskin Z. (Executive)

2016 - 2017

İnsan Uyarılmış Pluripotent Kök Hücrelerinden Limbal Epitel Kök Hücre Farklılaştırılmasının Geliştirilerek Optimizasyonu

Project Supported by Higher Education Institutions

Tokcaer Keskin Z. (Executive)

2014 - 2016

İndüklenmiş pluripotent kök hücrelerden farklılaştırılan kardiyomiyositlerde kimyasal ajanlar ve hipoksi ile oluşturulan hipertrofide β adrenerjik reseptörlerin rolü

TUBITAK Project

Tokcaer Keskin Z. (Executive) , Turan B.

2012 - 2015

KARACİĞER FİBROZİSİNDE FLT3 GENİNİN ETKİSİ VE BU ETKİNİN MOLEKÜLER MEKANİZMASI

TUBITAK Project

Akçalı K. C. (Executive)

2009 - 2010

HİPOKSİNİN MEZENKİMAL KÖK HÜCRELERİ ÜZERİNDEKİ ETKİSİNDE ÖSTROJENİN ROLÜ VE ETKİ MEKANİZMASI.

TUBITAK Project

Akçalı K. C. (Executive)

2006 - 2008

ÖSTROJENİN DENEYSEL HAYVAN MODELİ KULLANARAK MEZENKİMAL KÖK HÜCRE ÇOĞALMASI, FARLILAŞMASI VE HASARLI DOKUYA ULAŞMASINDAKİ ROLÜNÜN TANIMLANMASI

TUBITAK Project

Akçalı K. C. (Executive)

Activities in Scientific Journals

2021 - Continues

Acıbadem Sağlık Bilimleri Dergisi

Editor

2018 - 2018

Turkish Journal Of Biology

Special Issue Editor

Memberships / Tasks in Scientific Organizations

2019 - Continues

Medical Biology and Genetics Association

Member

2017 - Continues

Molecular Biology Association

Member

2008 - Continues

International Society for Stem Cell Research

Member

Scientific Refereeing

May 2021

TUBITAK Project

1001 - Program for Supporting Scientific and Technological Research Projects, Acibadem Mehmet Ali Aydinlar University, Turkey

March 2021

TURKISH JOURNAL OF BIOLOGY

Journal Indexed in SSCI

March 2021

TUBITAK Project

2209-A - Üniversite Öğrencileri Araştırma Projeleri Destekleme Programı, Acibadem Mehmet Ali Aydinlar University, Turkey

February 2021

JOURNAL OF APPLIED BIOLOGICAL SCIENCES

National Scientific Refreed Journal

December 2020

TUBITAK Project

1001 - Program for Supporting Scientific and Technological Research Projects, TÜBİTAK, Turkey

December 2020

TUBITAK Project

1001 - Program for Supporting Scientific and Technological Research Projects, TÜBİTAK, Turkey

December 2020

TUBITAK Project

1001 - Program for Supporting Scientific and Technological Research Projects, Acibadem Mehmet Ali Aydinlar University, Turkey

September 2020

TUBITAK Project

1001 - Program for Supporting Scientific and Technological Research Projects, TÜBİTAK, Turkey

August 2020

TUBITAK Project

1011 - International Scientific Research Projects Participation Program (UBAP), Acibadem Mehmet Ali Aydinlar University, Turkey

August 2020

TUBITAK Project

3501 - National Young Researcher Career Development Program, Acibadem Mehmet Ali Aydinlar University, Turkey

May 2020

TUBITAK Project

1001 - Program for Supporting Scientific and Technological Research Projects, Acibadem Mehmet Ali Aydinlar University, Turkey

May 2020

ICGEB Supported Project

TÜBİTAK, Turkey

April 2020

BIOCHEMICAL GENETICS

SCI Journal

March 2020

TUBITAK Project

1002 - Quick Support Program, Acibadem Mehmet Ali Aydinlar University, Turkey

March 2020

Project Supported by Higher Education Institutions

BAP Research Project, Acibadem Mehmet Ali Aydinlar University, Turkey

March 2020

Project Supported by Higher Education Institutions

BAP Research Project, Zonguldak Bülent Ecevit University, Turkey

March 2020

TUBITAK Project

1002 - Quick Support Program, Acibadem Mehmet Ali Aydinlar University, Turkey

March 2020

Project Supported by Higher Education Institutions

BAP Research Project, Zonguldak Bülent Ecevit University, Turkey

February 2020

TUBITAK Project

1001 - Program for Supporting Scientific and Technological Research Projects, Acibadem Mehmet Ali Aydinlar University, Turkey

January 2020

TUBITAK Project

1001 - Program for Supporting Scientific and Technological Research Projects, Acibadem Mehmet Ali Aydinlar University, Turkey

October 2019

TUBITAK Project

1001 - Program for Supporting Scientific and Technological Research Projects, TÜBİTAK, Turkey

October 2019

TUBITAK Project

1002 - Quick Support Program, TÜBİTAK, Turkey

October 2019

TUBITAK Project

1001 - Program for Supporting Scientific and Technological Research Projects, TÜBİTAK, Turkey

July 2019

TUBITAK Project

1001 - Program for Supporting Scientific and Technological Research Projects, TÜBİTAK, Turkey

June 2019

TUBITAK Project

1001 - Program for Supporting Scientific and Technological Research Projects, TÜBİTAK, Turkey

May 2019

TUBITAK Project

1001 - Program for Supporting Scientific and Technological Research Projects, TÜBİTAK, Turkey

May 2019

TUBITAK Project

1001 - Program for Supporting Scientific and Technological Research Projects, TÜBİTAK, Turkey

March 2017

TURKISH JOURNAL OF BIOLOGY

Journal Indexed in SCI-E

February 2017

TURKISH JOURNAL OF BIOLOGY

Journal Indexed in SCI-E

January 2017

TURKISH JOURNAL OF BIOLOGY

Journal Indexed in SCI-E

October 2016

TURKISH JOURNAL OF BIOLOGY

Journal Indexed in SCI-E

August 2016

TURKISH JOURNAL OF BIOLOGY

Journal Indexed in SCI-E

March 2016

TURKISH JOURNAL OF BIOLOGY

Journal Indexed in SCI-E

March 2016

TURKISH JOURNAL OF BIOLOGY

Journal Indexed in SCI-E

February 2016

TURKISH JOURNAL OF BIOLOGY

Journal Indexed in SCI-E

December 2015

TURKISH JOURNAL OF BIOLOGY

Journal Indexed in SCI-E

October 2015

TURKISH JOURNAL OF BIOLOGY

Journal Indexed in SCI-E

Awards

October 2014

Poster Award

European Sectıon Meetıng Of The Internatıonal Academy Of Cardıovascular Scıences

July 2009

Travel Award

International Society For Stem Cell Research

Edit Congress and Symposium Activities

2020

1st Bursa International Genetics Days: Dermatogenetics Symposium

Invited Speaker

Bursa-Turkey

2019