Biography
Dr. Perinur Bozaykut (Eker), lisans eğitimini Marmara Üniversitesi Biyoloji Bölümü’nde tamamladı. Yüksek lisans eğitimine Marmara Üniversitesi, Tıp Fakültesi, Biyokimya alanında devam eden Bozaykut, tez çalışmalarının bir kısmını kazandığı lisans sonrası eğitim bursuyla King’s College London bünyesinde Kalp ve Damar Bölümü’nde gerçekleştirdi. Doktora eğitimini Marmara Üniversitesi’nde tamamladıktan sonra Post-doktora araştırmalarını yürütmek üzere TUBİTAK desteği ile Harvard Medical School Genetik Bölümü’nde görev aldı. Doktora sonrası araştırmalarında, yaşlanmanın genetiği üzerine transkriptomiks bazlı araştırmalara ek olarak ilgili alanda ilaç araştırmalarına dahil oldu. Bu güne kadar yaptığı çalışmaları ile Physiological Society, SFRR-Europe, Türk Biyokimya derneği gibi kurumlardan ödüller kazandı. Devam eden bilimsel çalışmaları; kanser ve yaşlanmanın ilişkisinin genetik, farmakolojik ve beslenme gibi farklı yönlerden araştırılması üzerinedir.
Education Information
2011 - 2015
2011 - 2015Doctorate
Marmara University, Institute Of Health Sciences, Department Of Biochemistry, Turkey
2009 - 2011
2009 - 2011Post Graduate
Marmara University, Institute Of Health Sciences, Department Of Biochemistry, Turkey
Dissertations
2015
2015Doctorate
The Role of Endoplasmic Reticulum Stress and Nrf2 Pathway on High Cholesterol Diet İnduced Atherosclerosis
Marmara University, Institute Of Health Sciences
2011
2011Post Graduate
Hiperkolesterolemi modelinde lipit birikimi ve aterogenezde rol oynayan faktörlerin aydınlatılması
Marmara University, Institute Of Health Sciences, Department Of Biochemistry
Foreign Languages
C1 Advanced
C1 AdvancedEnglish
Research Areas
Biochemistry, Molecular Biology and Genetics
Academic Titles / Tasks
2019 - Continues
2019 - ContinuesAssistant Professor
Acibadem Mehmet Ali Aydinlar University, Faculty of Arts and Sciences, Molecular Biology and Genetics
2016 - 2019
2016 - 2019Assistant Professor
Istanbul Medipol University, Internatıonal Faculty Of Medıcıne, Department Of Basıc Medıcal Scıences (Medıcıne)
2016 - 2018
2016 - 2018Researcher
Harvard University, Medical School, Genetics
2015 - 2016
2015 - 2016Lecturer
Istanbul Medipol University, Internatıonal Faculty Of Medıcıne, Department Of Basıc Medıcal Scıences (Medıcıne)
Managerial Experience
2020 - Continues
2020 - ContinuesEthics Committee Member
Acibadem Mehmet Ali Aydinlar University, Faculty of Arts and Sciences, Molecular Biology and Genetics
Courses
Articles Published in Journals That Entered SCI, SSCI and AHCI Indexes
2020
2020High-throughput profiling reveals perturbation of endoplasmic reticulum stress-related genes in atherosclerosis induced by high-cholesterol diet and the protective role of vitamin E.
Bozaykut P. , Ekren R., Sezerman O. U. , Gladyshev V., Ozer N.
BioFactors (Oxford, England), 2020 (Journal Indexed in SCI Expanded)
2020
2020HSP70 Inhibition Leads to the Activation of Proteasomal System under Mild Hyperthermia Conditions in Young and Senescent Fibroblasts
Bozaykut P. , Sozen E., Kaga E., Ece A., Ozaltin E., Bergquist J., et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, vol.2020, 2020 (Journal Indexed in SCI)
2019
2019Identification and Application of Gene Expression Signatures Associated with Lifespan Extension
Tyshkovskiy A., Bozaykut P. , Borodinova A. A. , Gerashchenko M., Ables G. P. , Garratt M., et al.
CELL METABOLISM, vol.30, no.3, pp.573-601, 2019 (Journal Indexed in SCI)
2019
2019Aging and Cardiovascular Diseases: The Role of Cellular Senescence
BOZAYKUT EKER P.
OXIDATIVE STRESS IN HEART DISEASES, pp.207-233, 2019 (Journal Indexed in SCI)
2016
2016Nrf2 silencing to inhibit proteolytic defense induced by hyperthermia in HT22 cells
Bozaykut P. , Ozer N. K. , Karademir B.
REDOX BIOLOGY, vol.8, pp.323-332, 2016 (Journal Indexed in SCI)
2016
2016Endoplasmic reticulum stress related molecular mechanisms in nonalcoholic steatohepatitis
Bozaykut P. , ŞAHİN A., Karademir B., Ozer N. K.
MECHANISMS OF AGEING AND DEVELOPMENT, vol.157, pp.17-29, 2016 (Journal Indexed in SCI)
2014
2014Regulation of protein turnover by heat shock proteins
Bozaykut P. , Ozer N. K. , Karademir B.
FREE RADICAL BIOLOGY AND MEDICINE, vol.77, pp.195-209, 2014 (Journal Indexed in SCI)
2014
2014Heat shock proteins and proteasomal degradation in normal and tumor cells
Betul K., Perinur B. , Nesrin K. O.
FREE RADICAL BIOLOGY AND MEDICINE, vol.75, 2014 (Journal Indexed in SCI)
2014
2014The effect of Irisin on antioxidant system in liver
BATIREL S., Bozaykut P. , Altundag E. M. , Ozer N. K. , Mantzoros C. S.
FREE RADICAL BIOLOGY AND MEDICINE, vol.75, 2014 (Journal Indexed in SCI)
2014
2014The role of hypercholesterolemic diet and vitamin E on Nrf2 pathway, endoplasmic reticulum stress and proteasome activity
Perinur B. , Erdi S., Burak Y., Betul K., Nesrin K.
FREE RADICAL BIOLOGY AND MEDICINE, vol.75, 2014 (Journal Indexed in SCI)
2014
2014Effects of vitamin E on peroxisome proliferator-activated receptor gamma and nuclear factor-erythroid 2-related factor 2 in hypercholesterolemia-induced atherosclerosis
Bozaykut P. , Karademir B., Yazgan B., Sozen E., Siow R. C. M. , Mann G. E. , et al.
FREE RADICAL BIOLOGY AND MEDICINE, vol.70, pp.174-181, 2014 (Journal Indexed in SCI)
2014
2014Potential role of proteasome on c-jun related signaling in hypercholesterolemia induced atherosclerosis
Sozen E., Karademir B., Yazgan B., Bozaykut P. , Ozer N. K.
REDOX BIOLOGY, vol.2, pp.732-738, 2014 (Journal Indexed in SCI)
2013
2013Regulation of protein turnover by heat shock proteins
Karademir B., Sozen E., Bozaykut P. , Ece A., Ozaltin E., Ozer N. K. , et al.
FREE RADICAL BIOLOGY AND MEDICINE, vol.65, 2013 (Journal Indexed in SCI)
2013
2013The role of heat stress on the age related protein carbonylation
Bozaykut P. , Sozen E., Kaga E., Ece A., Ozaltin E., Ek B., et al.
JOURNAL OF PROTEOMICS, vol.89, pp.238-254, 2013 (Journal Indexed in SCI)
2012
2012The role of heat shock proteins in the protein oxidation during aging
Catalgol B., Sozen E., Bozaykut P. , Kaga E., Ozer N. K. , Grune T.
FREE RADICAL BIOLOGY AND MEDICINE, vol.53, 2012 (Journal Indexed in SCI)
2011
2011Age-related loss of stress-induced nuclear proteasome activation is due to low PARP-1 activity
Bakondi E., Catalgol B., Bak I., Jung T., Bozaykut P. , Bayramicli M., et al.
FREE RADICAL BIOLOGY AND MEDICINE, vol.50, no.1, pp.86-92, 2011 (Journal Indexed in SCI)
Articles Published in Other Journals
2021
2021Cellular stress responses of long-lived and cancer-resistant naked mole-rats
Bozaykut Eker P.
e-Türk Biyokimya Dergisi (elektronik), vol.46, no.2, pp.1-8, 2021 (Other Refereed National Journals)
Refereed Congress / Symposium Publications in Proceedings
2020
2020Yaşlı akciğer fibroblast hücrelerinde mTOR inhibitörlerinin senoteröpatik etkilerinin belirlenmesi
Bozaykut Eker P.
31. Ulusal Biyokimya Kogresi, 18 - 20 December 2020, pp.24
2020
2020Hypoxia-related mechanisms in cancer resistant animal models
Bozaykut Eker P.
9th International Molecular Biology and Biotechnology Congress, 6 - 10 December 2020, pp.54
2020
2020Identification of new anti-aging drugs by drug repurposing and their experimental validation by barcode-based RNA sequencing
Bozaykut Eker P.
V. Türkiye in vitro Diyagnostik Sempozyumu, Sağlık Biyoteknolojisi, İzmir, Turkey, 19 - 21 February 2020, pp.10
2018
2018High-throughput analysis of high-cholesterol diet induced atherosclerosis and the effect of endoplasmic reticulum stress
Bozaykut P.
III. Turkey in vitro Diagnostic (IVD) Symposium, İzmir, Turkey, 28 February - 02 March 2018, vol.43, no.1, pp.22-23
2016
2016Proteasomal system and heat shock proteins in cancer cell death mechanisms
Karademir B., Yılmaz A. M. , Altundag E. M. , Sozen E., Bozaykut Eker P. , Ozer N. K.
1st International Cell Death Research Congress, İstanbul, Turkey, 4 - 08 May 2016, pp.1
2015
2015Chemotherapy Resistance: The role of proteasomal degradation and heat shock response
Karademir B., Sozen E., Bozaykut P. , Altundag E. M. , Yilmaz A. M. , ŞAHİN A., et al.
SFRR-E/SNFS Conference, Stuttgart, Germany, 2 - 04 September 2015, vol.86
2015
2015Unfolded protein response to the hypercholesterolemia induced endoplasmic reticulum stress in atherosclerosis
Bozaykut P. , Karademir B., Ozer N. K.
40th Congress of the Federation-of-European-Biochemical-Societies (FEBS) - The Biochemical Basis of Life, Berlin, Germany, 4 - 09 July 2015, vol.282, pp.111
2015
2015Oxidative and Endoplasmic Reticulum Stress Related Molecular Mechanisms in Atherosclerosis
Bozaykut Eker P. , Karademir B., Kartal Özer N.
5th International Congress of Molecular Medicine, İzmir, Turkey, 20 - 22 May 2015, pp.30
2015
2015Inhibition of Molecular Mechanisms Related to Hyperthermia Induced Thermotolerence
Bozaykut Eker P. , Kartal Özer N., Karademir B.
3rd EACR-Sponsored Anticancer Agent Development Congress, İzmir, Turkey, 18 - 19 May 2015, pp.14
2014
2014The effect of proteasome on c-jun mediated signaling mechanisms in hypercholesterolemia induced oxidative stress
Sozen E., Karademir B., Yazgan B., Bozaykut P. , Ozer N. K.
FEBS EMBO 2014 Conference, Paris, France, 30 August - 04 September 2014, vol.281, pp.605
2014
2014Role of vitamin E on PPARgamma and Nrf2 related signalling pathways in in vivo model of atherosclerosis
Bozaykut P. , Karademir B., Yazgan B., Sozen E., Siow R., Mann G. E. , et al.
FEBS EMBO 2014 Conference, Paris, France, 30 August - 04 September 2014, vol.281, pp.675
2014
2014The role of HSP70 in the chemotherapeutic approach for proteasomal degradation and autophagy
Sozen E., Bozaykut Eker P. , Ozer N. K. , Grune T., Karademir B.
17th Biennial Meeting of Society for Free Radical Research International (SFRRI 2014), Kyoto, Japan, 23 May 2014, pp.1
2013
2013The Effect of Hypercholesterolemia Induced Oxidative Stress on Cardiac Failure and Autophagy Role of Vitamin E
Sözen A. E. , Yazgan B., Karademir B., Bozaykut Eker P. , Kaga E., Ozer N. K.
FEBS Special Meeting on Protein Quality Control and Ubiquitin Systems in Health and Disease, Aydın, Turkey, 14 - 16 November 2013, pp.78
2012
2012Effect of Hypercholesterolemic Diet and Vitamin E on Signal Transduction and Proteasomal System in Rabbit Aorta
Bozaykut P. , Sozen E., Catalgol B., Ozer N. K.
16th SFRRI Biennial Meeting, London, United Kingdom, 06 September 2012, pp.11
2012
2012Activation of AP-1 protein and related increase of matrix metalloproteinase expression in hypercholesterolemia induced atherosclerosis
Sozen E., Bozaykut P. , Catalgol B., Yazgan B., Ustunsoy S., Ozer N. K.
22nd IUBMB Congress/37th FEBS Congress, Sevilla, Spain, 4 - 09 September 2012, vol.279, pp.106
2013
2013Different response of proteasomal degradation in normal and tumor cells during heat stress
Catalgol B., Bozaykut P. , Ozer N. K. , Grune T.
Oxygen Club of California World Congress 2012, Cell Signaling, Gene-Nutrition Interactions, Turin, Italy, 20 June 2013, pp.47
2011
2011Heat shock proteins in the post translational modifications
Karademir B., Bozaykut P. , Sozen E., Kaga E., Grune T.
SFRR-Europe 2011 Meeting, Redox Biology and Micronutrients: From signaling to translation and back, İstanbul, Turkey, 07 September 2011, pp.54
2011
2011Induction of vascular antioxidant defences in response to dietary lipids and atherogenesis in hypercholesterolemic rabbits
Bozaykut P. , Catalgol B., Yazgan B., Sözen A. E. , Siow R., Mann G. E. , et al.
Physiology 2011 Congress, Oxford, United Kingdom, 11 - 14 July 2011, pp.45
2010
2010Expressions of Matrix Metalloproteinases in Atherosclerosis
Bozaykut P. , Catalgol B., Kaga E., Sozen E., Ozer N. K.
35th FEBS Congress Molecules of Life, Gothenburg, Sweden, 26 June 2010, pp.98
2010
2010The Main Genetic Pathways Playing Roles in Atherosclerosis
Bozaykut P. , Catalgol B., Kaga E., Sozen E., Kartal Özer N.
Protein maintenance and turnover in ageing & diseases, FEBS Advanced Lecture Course, Athens, Greece, 04 June 2010, pp.10
Books & Book Chapters
2019
2019Experimental Biochemistry for Medical Sciences Students
Yigitbasi T., Erdem S. S. , Bozaykut Eker P. , Emekli N.
Medipol Üniversitesi Yayınları, İstanbul, 2019
2019
2019Aging and Cardiovascular Diseases: The Role of Cellular Senescence
Bozaykut Eker P.
in: Oxidative Stress in Heart Diseases, Chakraborti S,Dhalla N,Ganguly N,Dikshit N, Editor, Springer, Singapore, pp.207-233, 2019
Memberships / Tasks in Scientific Organizations
2011 - Continues
2011 - ContinuesThe Physiological Society
Member
2011 - Continues
2011 - ContinuesTurkish Biochemical Society
Member
2011 - Continues
2011 - ContinuesSociety of Free Radical Research
Member
Scientific Consultations
2018 - 2018
2018 - 2018Scientific Consultancy
Eternans Biotechnology
Acibadem Mehmet Ali Aydinlar University, Faculty of Arts and Sciences, Molecular Biology and Genetics, Turkey
Awards
February 2020
February 2020Sözlü Sunum Ödülü
Türk Biyokimya Derneği
April 2015
April 2015Young Researcher Scholarship
Mokad
April 2013
April 2013Asistan Bildiri Yarışması birinciliği
Marmara Üniversitesi
September 2011
September 2011Early Research Career Award
Sfrr-Europe
July 2011
July 2011Poster Competition Award
The Physiological Society Uk
Edit Congress and Symposium Activities
2013
2013Lipid peroxidation by-products in metabolic diseases
Invited Speaker
Yerushalayim-Israel
Scholarships
2017 - 2018
2017 - 2018Postdoctoral Fellow
Other International Organizations
2016 - 2017
2016 - 2017