Asst. Prof.

Nazlı KESKİN TOKLU


Faculty of Arts and Sciences

Molecular Biology and Genetics

Biography

Assist. Prof. Dr. Nazlı KESKİN TOKLU received her Bachelor’s degree from Chemical Engineering Department at Marmara University in 2008. From Sabancı University, Biological Sciences and Bioengineering Program, she earned her MSc. degree in 2010 and PhD. degree in 2014 as a result of her studies on immunology and cancer, respectively, under the supervision of Prof. Dr. Batu ERMAN. Between 2014 and 2015, she worked as a postdoctoral fellow at Sabancı University. From 2015 to 2018, she worked as an assistant professor in Genetics and Bioengineering Department at Okan University.  In addition, she was also head of the same department between 2016 and 2018. Since 2018, she has been working as an assistant professor in Molecular Biology and Genetics Department at Acıbadem Mehmet Ali Aydınlar University. Her research mainly focuses on cancer molecular biology.

Education Information

2010 - 2014

2010 - 2014

Doctorate

Sabanci University, Instıtute Of Scıence, Biological Sciences and Bioengineering, Turkey

2008 - 2010

2008 - 2010

Postgraduate

Sabanci University, Instıtute Of Scıence, Biological Sciences and Bioengineering, Turkey

2003 - 2008

2003 - 2008

Undergraduate

Marmara University, Faculty Of Engineering, Chemical Engineering, Turkey

Dissertations

2014

2014

Doctorate

IDENTIFICATION OF PATZ1 TRANSCRIPTION FACTOR AS A NOVEL INTERACTING PARTNER AND REGULATOR OF THE p53 TUMOR SUPPRESSOR PROTEIN

Sabanci University, Instıtute Of Scıence, Biological Sciences and Bioengineering

2010

2010

Postgraduate

THE ROLE OF CD3 DELTA AND RAG1AP1 PROTEINS IN T CELL RECEPTOR EXPRESSION

Sabanci University, Instıtute Of Scıence, Biological Sciences and Bioengineering

Foreign Languages

B1 Intermediate

B1 Intermediate

German

C2 Mastery

C2 Mastery

English

Certificates, Courses and Trainings

2017

2017

Swiss Institute of Bioinformatics Course: Introduction to RNA Sequencing

Vocational Course

Swiss Institute of Bioinformatics

2015

2015

Yenilikçi Ar-Ge Mühendisliği Eğitimi

Innovative Product Design

İstanbul Okan Üniversitesi

2015

2015

İleri Excel, Veri Analizi Eğitimi

Vocational Training

Bilge Adam Akademi

2012

2012

EMBL Introductory Course: Confocal Microscopy

Vocational Course

The European Molecular Biology Laboratory (EMBL)

2011

2011

EMBL Introductory Course: Basic Light Microscopy

Vocational Course

The European Molecular Biology Laboratory (EMBL)

2003

2003

MUSEM German Language Certificate

Foreign Language

Marmara University Lifelong Learning Center (MUSEM)

Research Areas

Molecular Biology and Genetics, Genetic Engineering, Moleculer Biology of Cancer

Academic Titles / Tasks

2018 - Continues

2018 - Continues

Assistant Professor

Acibadem Mehmet Ali Aydinlar University, Faculty of Arts and Sciences, Molecular Biology and Genetics

2015 - 2018

2015 - 2018

Assistant Professor

Istanbul Okan University, Faculty Of Engıneerıng

2014 - 2015

2014 - 2015

Research Assistant PhD

Sabanci University, Faculty Of Engıneerıng And Natural Scıences, Biological Sciences and Bioengineering

Managerial Experience

2021 - Continues

2021 - Continues

Birim Stratejik Plan Komisyonu Üyesi

Acibadem Mehmet Ali Aydinlar University, Faculty of Arts and Sciences, Molecular Biology and Genetics

2018 - Continues

2018 - Continues

Moleküler Biyoloji ve Genetik Bölümü Akreditasyon Komisyonu Üyesi

Acibadem Mehmet Ali Aydinlar University, Faculty of Arts and Sciences, Molecular Biology and Genetics

2018 - Continues

2018 - Continues

Moleküler Biyoloji ve Genetik Bölümü Müfredat Komisyonu Üyesi

Acibadem Mehmet Ali Aydinlar University, Faculty of Arts and Sciences, Molecular Biology and Genetics

2016 - 2018

2016 - 2018

Head of Department

Istanbul Okan University, Faculty Of Engıneerıng

Courses

Undergraduate

Undergraduate

Immunology

Postgraduate

Postgraduate

Molecular and Translational Biomedicine

Undergraduate

Undergraduate

Biochemistry II

Postgraduate

Postgraduate

Molecular and Translational Biomedicine

Undergraduate

Undergraduate

Biochemistry I

Postgraduate

Postgraduate

Research Techniques and Ethics in Natural Sciences

Postgraduate

Postgraduate

Introduction to Molecular and Translational Biomedicine

Undergraduate

Undergraduate

Cell Cycle and Apoptosis

Postgraduate

Postgraduate

Cell Cycle and Apoptosis

Undergraduate

Undergraduate

Senior Project I

Undergraduate

Undergraduate

Senior Project II

Undergraduate

Undergraduate

Science of Nature I

Undergraduate

Undergraduate

Molecular Signal Pathways and Cancer

Undergraduate

Undergraduate

Protein Engineering

Undergraduate

Undergraduate

Genetik Mühendislik

Undergraduate

Undergraduate

Chemistry

Undergraduate

Undergraduate

Immunology

Undergraduate

Undergraduate

Molecular Cell Biology II

Undergraduate

Undergraduate

Genetik ve Biyomühendislik Dizayn

Undergraduate

Undergraduate

Biochemistry and Genetics Research Techniques II

Undergraduate

Undergraduate

Graduation Project

Undergraduate

Undergraduate

Mathematics I

Undergraduate

Undergraduate

İnterdisipliner Biyomühendislik

Articles Published in Journals That Entered SCI, SSCI and AHCI Indexes

2015

2015

PATZ1 Is a DNA Damage-Responsive Transcription Factor That Inhibits p53 Function

Keskin N. , Deniz E. , Eryilmaz J., Un M., Batur T., Ersahin T., et al.

MOLECULAR AND CELLULAR BIOLOGY, vol.35, no.10, pp.1741-1753, 2015 (Journal Indexed in SCI) identifier identifier identifier

Refereed Congress / Symposium Publications in Proceedings

2021

2021

Identifying Novel Gene Products Conferring Drug Resistance In Cancer Chemotherapy

Deniz E. , Kılıç İ. B. , Baran G., Yılmaz Z. H. , Nalbant N., Kavaklıoğlu B., et al.

8th Multidisciplinary Cancer Research Congress, 16 - 17 January 2021, pp.93

2019

2019

Identification of resistance mechanisms against cytotoxic drugs using genome-wide CRISPR/Cas9 Knock-out screening approach

Yılmaz Z. H. , Tokcaer Keskin Z. , Keskin Toklu N. , Deniz E.

Seventh International Congress of the Molecular Biology Association of Turkey, İstanbul, Turkey, 27 - 29 September 2019, pp.172

2019

2019

A long noncoding RNA repressed by DNA damage mediates cell survival and proliferation

Baran G., Kılıç I. B. , Keskin Toklu N. , Tokcaer Keskin Z. , Deniz E.

Seventh International Congress of the Molecular Biology Association of Turkey, İstanbul, Turkey, 27 - 29 September 2019, pp.83

2019

2019

Genome-wide screening of resistance mechanisms against cytotoxic drugs

Yılmaz Z. H. , Tokcaer Keskin Z. , Keskin Toklu N. , Deniz E.

Organelle Biogenesis and Function in Cell physiology and in Disease conference, İstanbul, Turkey, 27 - 28 May 2019, pp.65

2019

2019

A long noncoding RNA repressed by DNA damage mediates cell survival and proliferation

Baran G., Keskin Toklu N. , Tokcaer Keskin Z. , Deniz E.

Organelle Biogenesis and Function in Cell physiology and in Disease conference, İstanbul, Turkey, 27 - 28 May 2019, pp.55

2019

2019

A long noncoding RNA repressed by DNA damage mediates cell survival and proliferation

Baran G., Keskin Toklu N. , Tokcaer Keskin Z. , Deniz E.

International Molecular Medicine Symposium by the Bosphorus, İstanbul, Turkey, 16 - 18 May 2019, pp.45

2019

2019

Genome-wide screening of resistance mechanisms against cytotoxic drugs

Yılmaz Z. H. , Tokcaer Keskin Z. , Keskin Toklu N. , Deniz E.

International Molecular Medicine Symposium by the Bosphorus, İstanbul, Turkey, 16 - 18 May 2019, pp.44

2017

2017

The Role of Long Noncoding RNA DANCR in the DNA Damage Response

Baran G., Taluğ B., Keskin N. , Tokcaer Keskin Z. , Erman M. B. , Deniz E.

Fifth International Congress of the Molecular Biology Association of Turkey, İstanbul, Turkey, 8 - 10 September 2017, pp.70

2017

2017

Development of Novel Compounds as Chemotherapeutic Drugs Targeting the p53-MDM2 and - MDM4 Interaction

Taşkıran H., Tolay N., Gezen M., Keskin N. , Erman M. B.

Fifth International Congress of the Molecular Biology Association of Turkey, Istanbul, TURKEY, İstanbul, Turkey, 8 - 10 September 2017, pp.188

2015

2015

The Role of PATZ1 Transcription Factor in the DNA Damage Response

Deniz E. , Keskin N. , Atalay R., Erşahin T., Erman M. B.

Fourth International Congress of the Molecular Biology Association of Turkey, Ankara, Turkey, 27 - 29 November 2015, pp.125

2014

2014

The Role of PATZ1 Transcription Factor in the DNA Damage Response

Deniz E. , Keskin N. , Atalay R., Erşahin T., Sakaguchi S., Ellmeier W., et al.

Third International Congress of the Molecular Biology Association of Turkey, İzmir, Turkey, 10 - 12 September 2014, pp.152

2014

2014

Identification of PATZ1 Transcription Factor as a Novel Interacting Partner and Regulator of the p53 Tumor Suppressor Protein

Keskin N. , Deniz E. , Ün M., Eryılmaz J., Erman M. B.

Third International Congress of the Molecular Biology Association of Turkey, İzmir, Turkey, 10 - 12 September 2014, pp.155

2014

2014

The BTB-ZF Transcription Factor PATZ1 Functionally Interacts with p53

Deniz E. , Keskin N. , Sakaguchi S., Ellmeier W., Erman M. B.

16th International p53 Workshop, Stockholm, Sweden, 15 - 19 June 2014, pp.137

2014

2014

The Tumor Suppressor p53 Functionally Interacts With PATZ1

Keskin N. , Deniz E. , Ün M., Eryılmaz J., Erman M. B.

16th International p53 Workshop, Stockholm, Sweden, 15 - 19 June 2014, pp.191

2014

2014

The Tumor Suppressor p53 Interacts With PATZ1 Expressed During T Cell Development

Keskin N. , Deniz E. , Ün M., Eryılmaz J., Erman M. B.

Second International Molecular Immunology & Immunogenetics Congress (MIMIC-II), Antalya, Turkey, 27 - 30 April 2014, pp.50

2014

2014

CD4 versus CD8 T Cell Lineage Fate Determinant PATZ1 Functionally Interacts with p53

Deniz E. , Keskin N. , Ün M., Eryılmaz J., Sakaguchi S., Ellmeier W., et al.

Second International Molecular Immunology & Immunogenetics Congress (MIMIC-II), Antalya, Turkey, 27 - 30 April 2014, pp.53

2013

2013

The Tumor Suppressor p53 Interacts With PATZ1 Expressed During T Cell Development

Keskin N. , Deniz E. , Ün M., Eryılmaz J., Erman M. B.

Second International Congress of the Molecular Biology Association of Turkey, İstanbul, Turkey, 22 - 23 November 2013, pp.51

2013

2013

CD4 vs CD8 T Cell Lineage Fate Determinant PATZ1 Functionally Interacts with p53

Deniz E. , Keskin N. , Ün M., Eryılmaz J., Sakaguchi S., Ellmeier W., et al.

Second International Congress of the Molecular Biology Association of Turkey, İstanbul, Turkey, 22 - 23 November 2013, pp.94

2013

2013

The Tumor Suppressor p53 Interacts With PATZ1 Expressed During T Cell Development

Keskin N. , Deniz E. , Ün M., Eryılmaz J., Erman M. B.

Fifth EMBO Meeting, Amsterdam, Netherlands, 21 - 24 September 2013, pp.91

2013

2013

The Tumor Suppressor p53 Binds PATZ1 Expressed During T Cell Development

Keskin N. , Deniz E. , Ün M., Eryılmaz J., Sakaguchi S., Ellmeier W., et al.

22. Ulusal Immunoloji Kongresi, İzmir, Turkey, 27 - 30 April 2013, pp.125

2013

2013

CD4 vs CD8 T Cell Lineage Fate Determinant PATZ1 Functionally Interacts with p53

Deniz E. , Keskin N. , Ün M., Eryılmaz J., Sakaguchi S., Ellmeier W., et al.

22. Ulusal Immunoloji Kongresi, İzmir, Turkey, 27 - 30 April 2013, pp.132

2012

2012

The Role of CD3 Delta and RAG1AP1 Proteins in T-Cell Receptor Expression

Keskin N. , Çevik Ş. I. , Erman M. B.

First International Congress of the Molecular Biology Association of Turkey, İstanbul, Turkey, 23 - 24 November 2012, pp.77

2012

2012

The Role of CD3 Delta and RAG1AP1 Proteins in T-Cell Receptor Expression

Keskin N. , Çevik Ş. I. , Erman M. B.

Fourth EMBO Meeting, Nice, France, 22 - 25 September 2012, pp.39

2012

2012

The Role of CD3 Delta and RAG1AP1 Proteins in T-Cell Receptor Expression

Keskin N. , Çevik Ş. I. , Erman M. B.

EMBO Young Scientists’ Forum, İstanbul, Turkey, 14 - 16 June 2012, pp.1

2010

2010

The Role of CD3 Delta and RAG1AP1 Proteins in T-Cell Receptor Expression

Keskin N. , Çevik Ş. I. , Erman M. B.

FEBS-EFIS Workshop: Inflammatory Diseases and Immune Response: Basic Aspects, Novel Approaches and Experimental Models, Vienna, Austria, 28 September - 01 November 2010, pp.22

Memberships / Tasks in Scientific Organizations

2019 - Continues

2019 - Continues

Medical Biology and Genetics Association

Member

2011 - Continues

2011 - Continues

Molecular Biology Association

Member

2011 - Continues

2011 - Continues

Turkish Society of Immunology

Member

Scientific Refereeing

September 2021

September 2021

FUNCTIONAL & INTEGRATIVE GENOMICS

Journal Indexed in SCI-E

August 2021

August 2021

FUNCTIONAL & INTEGRATIVE GENOMICS

Journal Indexed in SCI-E

August 2021

August 2021

FUNCTIONAL & INTEGRATIVE GENOMICS

Journal Indexed in SCI-E

August 2021

August 2021

TUBITAK Project

1005 - National New Ideas and Products Research Support Program, Acibadem Mehmet Ali Aydinlar University, Turkey

August 2021

August 2021

TUBITAK Project

1002 - Quick Support Program, Acibadem Mehmet Ali Aydinlar University, Turkey

July 2021

July 2021

FUNCTIONAL & INTEGRATIVE GENOMICS

Journal Indexed in SCI-E

July 2021

July 2021

FUNCTIONAL & INTEGRATIVE GENOMICS

Journal Indexed in SCI-E

June 2021

June 2021

ACIBADEM SAĞLIK BİLİMLERİ DERGİSİ

National Scientific Refreed Journal

June 2021

June 2021

FUNCTIONAL & INTEGRATIVE GENOMICS

Journal Indexed in SCI-E

May 2021

May 2021

FUNCTIONAL & INTEGRATIVE GENOMICS

Journal Indexed in SCI-E

May 2021

May 2021

FUNCTIONAL & INTEGRATIVE GENOMICS

Journal Indexed in SCI-E

April 2021

April 2021

FUNCTIONAL & INTEGRATIVE GENOMICS

Journal Indexed in SCI-E

April 2021

April 2021

TUBITAK Project

1002 - Quick Support Program, Turkey

April 2021

April 2021

Project Supported by Higher Education Institutions

BAP Research Project, Erciyes University, Turkey

March 2021

March 2021

FUNCTIONAL & INTEGRATIVE GENOMICS

Journal Indexed in SCI-E

March 2021

March 2021

FUNCTIONAL & INTEGRATIVE GENOMICS

Journal Indexed in SCI-E

February 2021

February 2021

FUNCTIONAL & INTEGRATIVE GENOMICS

Journal Indexed in SCI-E

February 2021

February 2021

Project Supported by Higher Education Institutions

BAP Research Project, Erciyes University, Turkey

January 2021

January 2021

FUNCTIONAL & INTEGRATIVE GENOMICS

Journal Indexed in SCI-E

December 2020

December 2020

FUNCTIONAL & INTEGRATIVE GENOMICS

Journal Indexed in SCI-E

December 2020

December 2020

HACETTEPE JOURNAL OF BİOLOGY AND CHEMİSTRY

National Scientific Refreed Journal

December 2020

December 2020

FUNCTIONAL & INTEGRATIVE GENOMICS

Journal Indexed in SCI-E

December 2020

December 2020

FUNCTIONAL & INTEGRATIVE GENOMICS

Journal Indexed in SCI-E

December 2020

December 2020

TUBITAK Project

1002 - Quick Support Program, TÜBİTAK, Turkey

November 2020

November 2020

FUNCTIONAL & INTEGRATIVE GENOMICS

Journal Indexed in SCI-E

November 2020

November 2020

FUNCTIONAL & INTEGRATIVE GENOMICS

Journal Indexed in SCI-E

October 2020

October 2020

FUNCTIONAL & INTEGRATIVE GENOMICS

Journal Indexed in SCI-E

October 2020

October 2020

FUNCTIONAL & INTEGRATIVE GENOMICS

Journal Indexed in SCI-E

September 2020

September 2020

FUNCTIONAL & INTEGRATIVE GENOMICS

Journal Indexed in SCI-E

September 2020

September 2020

FUNCTIONAL & INTEGRATIVE GENOMICS

Journal Indexed in SCI-E

August 2020

August 2020

TUBITAK Project

1002 - Quick Support Program, TÜBİTAK, Turkey

July 2019

July 2019

SCIENTIFIC REPORTS

SCI Journal

February 2019

February 2019

SCIENTIFIC REPORTS

SCI Journal

September 2018

September 2018

TURKISH JOURNAL OF BIOLOGY

Journal Indexed in SCI-E

Awards

April 2013

April 2013

Poster Ödülü (Birincilik)

22. Ulusal İmmünoloji Kongresi

June 2012

June 2012

Poster Ödülü (Birincilik)

European Molecular Biology Organization (Embo)

June 2010

June 2010

University Courses Teaching Assistant Incentive Award for Exceptional Performance in MATH101

Sabancı Üniversitesi



Edit Congress and Symposium Activities

2017

2017

24th National Immunology Congress

Invited Speaker

İstanbul-Turkey

Invited Talks

March 2018

March 2018

How Does PATZ1 Bind And Inhibit p53, The Master Guardian Of The Genome

Seminar

Gebze Teknik Üniversitesi-Turkey

April 2017

April 2017

Current Applications In Immunology: In Vitro Genome Editing Methods

Conference

Turkish Immunology Society-Turkey

Scholarships

2010 - 2014

2010 - 2014

TUBITAK BIDEB Doctorate Scholarship

TUBITAK

2010 - 2014

2010 - 2014

PhD. Education Tuition Fee (100%)

University

2008 - 2010

2008 - 2010

Master Education Tuition Fee (100%)

University

2008 - 2010

2008 - 2010

TUBITAK BIDEB Master Scholarship

TUBITAK

Jury Memberships

July-2021

July 2021

Post Graduate

Post Graduate - Gebze Teknik Üniversitesi

July-2021

July 2021

Post Graduate

Post Graduate - Gebze Teknik Üniversitesi

July-2021

July 2021

Post Graduate

Post Graduate - Acıbadem Mehmet Ali Aydınlar Üniversitesi

June-2021

June 2021

Doctoral Examination

Doctoral Examination - Gebze Teknik Üniversitesi

August-2020

August 2020

Post Graduate

Post Graduate - Acıbadem Mehmet Ali Aydınlar Üniversitesi

July-2020

July 2020

Doctoral Examination

Doctoral Examination - Gebze Teknik Üniversitesi

July-2020

July 2020

Doctoral Examination

Doctoral Examination - Gebze Teknik Üniversitesi

January-2020

January 2020

Doctoral Examination

Doctoral Examination - Gebze Teknik Üniversitesi

January-2020

January 2020

Doctoral Examination

Doctoral Examination - Gebze Teknik Üniversitesi

January-2020

January 2020

Doctoral Examination

Doctoral Examination - Gebze Teknik Üniversitesi

July-2019

July 2019

Post Graduate

Post Graduate - Acıbadem Mehmet Ali Aydınlar Üniversitesi

July-2019

July 2019

Post Graduate

Post Graduate - Sabancı Üniversitesi

June-2019

June 2019

Doctoral Examination

Doctoral Examination - Gebze Teknik Üniversitesi

May-2019

May 2019

Competition

Prof. Dr. Gazi Yaşargil Fen Bilimleri Araştırma Projeleri Yarışması - Fenerbahçe Koleji

February-2019

February 2019

Award

Jury Member Of The Committee For Poster Awards - Acıbadem Mehmet Ali Aydınlar Üniversitesi

February-2019

February 2019

Doctoral Examination

Doctoral Examination - Gebze Teknik Üniversitesi

January-2019

January 2019

Doctoral Examination

Doctoral Examination - Gebze Teknik Üniversitesi

December-2017

December 2017

Post Graduate

Post Graduate - Acıbadem Mehmet Ali Aydınlar Üniversitesi

June-2017

June 2017

Doctorate

Doctorate - Sabancı Üniversitesi