Öğr.Gör.Dr.

GÜRALP ONUR CEYHAN


Tıp Fakültesi

Cerrahi Tıp Bilimleri Bölümü

Genel Cerrahi Anabilim Dalı

Biyografi

   Prof. Dr Güralp Onur CEYHAN was born in 1974, Ankara. Prof. Dr Güralp Onur CEYHAN graduated from Medicine School WWU Münster in 2002 and completed his MD thesis study “Administration of magnesium reduces the severity of cerulein induced acute pancreatitis and premature activation of proteases in isolated acini cells” in 2003, under the supervision of Prof. Dr Markus Lerch at the Department of Gastroenterology, University of Münster. Following success in Münster, he has maintained his studies at the European Pancreatic Centre in the Section Pancreatic Molecular Biology and Surgery at the University of Heidelberg under the supervision of Prof. Dr Helmut Friess. Here he has established his pioneering work with the neuro-cancer interactions in pancreatic cancer. Between 2007-2018, he was appointed as principal investigator of the “Pancreatic Neuropathy and Pain” division at the Pancreatic Research Center at the Department of Surgery at the Klinikum Rechts der Isar, Technical University of Munich, Germany. Since 2014 he was also leading the entire Pancreatic Research Center, was head of the hepato-pancreatico-biliary surgery unit and the Vice-Chairman of the Department of Surgery. Prof. Dr Güralp Onur Ceyhan’s main reaserch focus was concentrated on neuro-cancer and neuro-immune interactions in pancreatic cancer and chronic pancreatitis. He and his team have established the term Pancreatic Neuropathy and characterized the neuropathic pain sensation in pancreatic cancer and chronic pancreatitis patients. He published more than 100 articles with a total impact factor 565, over 3000 citations and a H-index of 33. In 2010, he was proudly selected as one of the members of the “Academy of Excellence (Exzellenzakademie)” in academic general surgery in Germany. In 2019, he returned to his country to join the Acıbadem Group as the chair of the hepato-pancreatico-biliary surgery unit Recently, his  three TUBITAK and TUSEB  projects were funded with a total 4.4 million TL budget.  Among them,  TUBITAK-BIDEB 2232 International Fellowship for Outstanding Researchers project was funded with 2.6 million TL budget.

Eğitim Bilgileri

2002 - 2003

2002 - 2003

Tıpta Uzmanlık

Westfaelische Wilhelms-Universitaet Münster, School of Medicine, Department of Gastroenterology, Almanya

1995 - 2002

1995 - 2002

Lisans

Westfaelische Wilhelms-Universitaet Münster, School of Medicine, Almanya

Yabancı Diller

C2 Yeterlilik

C2 Yeterlilik

Almanca

C2 Yeterlilik

C2 Yeterlilik

İngilizce

Araştırma Alanları

Sağlık Bilimleri

Akademik Unvanlar / Görevler

2020 - Devam Ediyor

2020 - Devam Ediyor

Prof.Dr.

Acıbadem Mehmet Ali Aydınlar Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü

2007 - 2019

2007 - 2019

Prof.Dr.

Technische Universitaet München, Klinikum rechts der Isar, Department of Surgery

2002 - 2007

2002 - 2007

Uzman Dr.

Universitaed Heidelberg, School of Medicine, European Pancreatic Centre

1999 - 2002

1999 - 2002

Doktor

Westfaelische Wilhelms-Universitaet Münster, School of Medicine, Department of Gastroentology

Yönetimsel Görevler

2015 - 2019

2015 - 2019

Bölüm Başkan Yardımcısı

Technische Universitaet München, School of Medicine, Klinikum rechts der Isar

2014 - 2019

2014 - 2019

Bölüm Başkanı

Technische Universitaet München, School of Medicine , Department of Surgery

SCI, SSCI ve AHCI İndekslerine Giren Dergilerde Yayınlanan Makaleler

2020

2020

Delaying surgery for patients with a previous SARS-CoV-2 infection.

Glasbey J. C. , Nepogodiev D., Omar O., Simoes J. F. , Ademuyiwa A., Fiore M., et al.

The British journal of surgery, cilt.107, 2020 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

2020

2020

The quality of pain management in pancreatic cancer: A prospective multi-center study

Damm M., Weniger M., Koelsch A., Lampert C., Ceyhan G. , Beer S., et al.

PANCREATOLOGY, cilt.20, ss.1511-1518, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2020

2020

Mechanisms of T-Cell Exhaustion in Pancreatic Cancer

Saka D., Gokalp M., Piyade B., Cevik N. C. , Sever E. A. , Unutmaz D., et al.

CANCERS, cilt.12, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2020

2020

Diabetes and Weight Loss Are Associated With Malignancies in Patients With Intraductal Papillary Mucinous Neoplasms.

Pergolini I., Jäger C., Safak O., Göß R., Novotny A., Ceyhan G. , et al.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2020 (SCI Expanded İndekslerine Giren Dergi) identifier

2020

2020

Meta-analysis and single-center experience on the protective effect of negative suction drains on wound healing after stoma reversal

Neumann P., Reischl S., Berg F., Jaeger C., Friess H., Reim D., et al.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, cilt.35, ss.403-411, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2019

2019

Ductal obstruction promotes formation of preneoplastic lesions from the pancreatic ductal compartment

Cheng T., Zhang Z., Jian Z., Raulefs S., Schlitter A. M. , Steiger K., et al.

INTERNATIONAL JOURNAL OF CANCER, cilt.144, ss.2529-2538, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2018

2018

Risk of malignancy in resected pancreatic mucinous cystic neoplasms

Keane M. G. , Shamali A., Nilsson L. N. , Antila A., Bocos J. M. , Van Zanten M. M. , et al.

BRITISH JOURNAL OF SURGERY, cilt.105, ss.439-446, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2018

2018

MTOR inhibitor-based combination therapies for pancreatic cancer

Hassan Z., Schneeweis C., Wirth M., Veltkamp C., Dantes Z., Feuerecker B., et al.

BRITISH JOURNAL OF CANCER, cilt.118, ss.366-377, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2018

2018

Glycemic Variability Promotes Both Local Invasion and Metastatic Colonization by Pancreatic Ductal Adenocarcinoma

Jian Z., Cheng T., Zhang Z., Raulefs S., Shi K., Steiger K., et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, cilt.6, ss.429-449, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2018

2018

3D Cancer Migration Assay with Schwann Cells

Fangmann L., Teller S., Stupakov P., Friess H., Ceyhan G. , Demir I. E.

SCHWANN CELLS: METHODS AND PROTOCOLS, cilt.1739, ss.317-325, 2018 (SCI İndekslerine Giren Dergi) identifier identifier

2017

2017

Calcium Imaging of Nerve-Mast Cell Signaling in the Human Intestine.

Buhner S., Barki N., Greiter W., Giesbertz P., Demir I., Ceyhan G. , et al.

Frontiers in physiology, cilt.8, ss.971, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2017

2017

Resection of main duct and mixed type IPMN >= 5 mm

Ceyhan G. O. , Scheufele F., Friess H.

CHIRURG, cilt.88, ss.913-917, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2017

2017

Reply to Letter: "Neural Invasion Cannot be Controlled by Extended Surgery in Gastric Cancer''

Ceyhan G.

ANNALS OF SURGERY, cilt.265, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2017

2017

Epigenomic therapies: the potential of targeting SIRT6 for the treatment of pancreatic cancer

Demir I. E. , Ceyhan G. O. , Friess H.

EXPERT OPINION ON THERAPEUTIC TARGETS, cilt.21, ss.1-3, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2017

2017

Early pancreatic cancer lesions suppress pain through CXCL12-mediated chemoattraction of Schwann cells

Demir I. E. , Kujundzic K., Pfitzinger P. L. , Saricaoglu O. C. , Teller S., Kehl T., et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, cilt.114, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2016

2016

Anti-Hu antibodies activate enteric and sensory neurons

Li Q., Michel K., Annahazi A., Demir I. E. , Ceyhan G. O. , Zeller F., et al.

SCIENTIFIC REPORTS, cilt.6, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2016

2016

Neural influences on human intestinal epithelium in vitro

Krueger D., Michel K., Zeller F., Demir I. E. , Ceyhan G. O. , Slotta-Huspenina J., et al.

JOURNAL OF PHYSIOLOGY-LONDON, cilt.594, ss.357-372, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2015

2015

Mechanical stress activates neurites and somata of myenteric neurons

Kugler E. M. , Michel K., Zeller F., Demir I. E. , Ceyhan G. O. , Schemann M., et al.

FRONTIERS IN CELLULAR NEUROSCIENCE, cilt.9, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2015

2015

Association Between Pancreatic Intraductal Papillary Mucinous Neoplasms and Extrapancreatic Malignancies

Marchegiani G., Malleo G., D'Haese J. G. , Wenzel P., Keskin M., Pugliese L., et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, cilt.13, ss.1162-1169, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2015

2015

Pancreatic fibrosis and standard diagnostics

Ceyhan G. , Friess H.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, cilt.12, ss.69-70, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2014

2014

Update on surgical treatment of pancreatic neuroendocrine neoplasms

D'Haese J. G. , Tosolini C., Ceyhan G. , Kong B., Esposito I., Michalski C. W. , et al.

WORLD JOURNAL OF GASTROENTEROLOGY, cilt.20, ss.13893-13898, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2014

2014

Investigation of Schwann Cells at Neoplastic Cell Sites Before the Onset of Cancer Invasion

Demir I. E. , Boldis A., Pfitzinger P. L. , Teller S., Brunner E., Klose N., et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, cilt.106, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2014

2014

Pain sensation in pancreatic diseases is not uniform: The different facets of pancreatic pain

D'Haese J. G. , Hartel M., Demir I. E. , Hinz U., Bergmann F., Buechler M. W. , et al.

WORLD JOURNAL OF GASTROENTEROLOGY, cilt.20, ss.9154-9161, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2014

2014

Simulating Pancreatic Neuroplasticity: In Vitro Dual-neuron Plasticity Assay

Demir I. E. , Tieftrunk E., Schaefer K., Friess H., Ceyhan G.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2013

2013

S3-Guideline Exocrine Pancreatic Cancer

Seufferlein T., Porzner M., Becker T., Budach V., Ceyhan G. O. , Esposito I., et al.

ZEITSCHRIFT FUR GASTROENTEROLOGIE, cilt.51, ss.1395-1440, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2013

2013

Effect of hyoscine butylbromide (Buscopan((R))) on cholinergic pathways in the human intestine

Krueger D., Michel K., Allam S., Weiser T., Demir I. E. , Ceyhan G. O. , et al.

NEUROGASTROENTEROLOGY AND MOTILITY, cilt.25, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2013

2013

The Severity of Neural Invasion Is Associated with Shortened Survival in Colon Cancer

Liebl F., Demir I. E. , Rosenberg R., Boldis A., Yildiz E., Kujundzic K., et al.

CLINICAL CANCER RESEARCH, cilt.19, ss.50-61, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2012

2012

Neuronal plasticity in chronic pancreatitis is mediated via the neurturin/GFR alpha 2 axis

Demir I. E. , Wang K., Tieftrunk E., Giese N. A. , Xing B., Friess H., et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, cilt.303, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2012

2012

Therapeutic potential of the chemokine-receptor duo fractalkine/CX3CR1: an update

D'Haese J. G. , Friess H., Ceyhan G.

EXPERT OPINION ON THERAPEUTIC TARGETS, cilt.16, ss.613-618, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2012

2012

Nerve-cancer interactions in the stromal biology of pancreatic cancer

Demir I. E. , Friess H., Ceyhan G.

FRONTIERS IN PHYSIOLOGY, cilt.3, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2011

2011

Activity of Protease-Activated Receptors in the Human Submucous Plexus

Mueller K., Michel K., Krueger D., Demir I. E. , Ceyhan G. , Zeller F., et al.

GASTROENTEROLOGY, cilt.141, ss.2088-2098, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2011

2011

Pigment Epithelium-Derived Factor Associates With Neuropathy and Fibrosis in Pancreatic Cancer

Samkharadze T., Erkan M., Reiser-Erkan C., Demir I. E. , Kong B., Ceyhan G. , et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY, cilt.106, ss.968-980, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2011

2011

Pain mechanisms in chronic pancreatitis: of a master and his fire

Demir I. E. , Tieftrunk E., Maak M., Friess H., Ceyhan G.

LANGENBECKS ARCHIVES OF SURGERY, cilt.396, ss.151-160, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2010

2010

Recordings from human myenteric neurons using voltage-sensitive dyes

Vignali S., Peter N., Ceyhan G. , Demir I. E. , Zeller F., Senseman D., et al.

JOURNAL OF NEUROSCIENCE METHODS, cilt.192, ss.240-248, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2010

2010

Neural invasion in pancreatic cancer: the past, present and future.

Demir I., Ceyhan G. , Liebl F., D'Haese J., Maak M., Friess H.

Cancers, cilt.2, ss.1513-27, 2010 (SCI Expanded İndekslerine Giren Dergi) identifier identifier

2010

2010

Fate of nerves in chronic pancreatitis: Neural remodeling and pancreatic neuropathy

Ceyhan G. , Demir I. E. , Maak M., Friess H.

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, cilt.24, ss.311-322, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2010

2010

The microenvironment in chronic pancreatitis and pancreatic cancer induces neuronal plasticity

Demir I. E. , Ceyhan G. O. , Rauch U., Altintas B., Klotz M., Mueller M. W. , et al.

NEUROGASTROENTEROLOGY AND MOTILITY, cilt.22, ss.480-492, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2010

2010

Fractalkine/CX3CR1: why a single chemokine-receptor duo bears a major and unique therapeutic potential

D'Haese J. G. , Demir I. E. , Friess H., Ceyhan G.

EXPERT OPINION ON THERAPEUTIC TARGETS, cilt.14, ss.207-219, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2008

2008

Neural invasion in pancreatic cancer: A mutual tropism between neurons and cancer cells

Ceyhan G. , Demir I. E. , Altintas B., Rauch U., Thiel G., Mueller M. W. , et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, cilt.374, ss.442-447, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2008

2008

Pancreatic pain

Ceyhan G. , Michalski C. W. , Demir I. E. , Mueller M. W. , Friess H.

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, cilt.22, ss.31-44, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2007

2007

Association of axon guidance factor Semaphorin 3A with poor outcome in pancreatic cancer

Mueller M. W. , Giese N. A. , Swiercz J. M. , Ceyhan G. , Esposito I., Hinz U., et al.

INTERNATIONAL JOURNAL OF CANCER, cilt.121, ss.2421-2433, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2007

2007

Is there still a role for total pancreatectomy?

Mueller M. W. , Friess H., Kleeff J., Dahmen R., Wagner M., Hinz U., et al.

ANNALS OF SURGERY, cilt.246, ss.966-975, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2006

2006

The neurotrophic factor artemin promotes pancreatic cancer invasion

Ceyhan G. , Giese N. A. , Erkan M., Kerscher A. G. , Wente M. N. , Giese T., et al.

ANNALS OF SURGERY, cilt.244, ss.274-281, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

2005

2005

The Notch signaling pathway is related to neurovascular progression of pancreatic cancer

Buchler P., Gazdhar A., Schubert M., Giese N., Reber H., Hines O., et al.

ANNALS OF SURGERY, cilt.242, ss.791-801, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Diğer Dergilerde Yayınlanan Makaleler

2020

2020

The Youngest Patient with Metastatic Leiomyosarcoma of the Pancreas.

Saka D., Şişman G. , Özer L. , Şahin D., Ceyhan G.

Journal of gastrointestinal cancer, cilt.51, ss.722-723, 2020 (Diğer Kurumların Hakemli Dergileri) identifier identifier identifier

2019

2019

Venous resection during pancreatectomy for pancreatic cancer: a systematic review

Wang X., Demir I. E. , Schorn S., Jaeger C., Scheufele F., Friess H., et al.

TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY, cilt.4, 2019 (ESCI İndekslerine Giren Dergi) identifier identifier identifier

2015

2015

Back pain as a potential indicator of local recurrence in pancreatic cancer

Tieftrunk E., Demir I. E. , Friess H., Ceyhan G. O.

JOURNAL OF SURGICAL CASE REPORTS, 2015 (ESCI İndekslerine Giren Dergi) identifier identifier

Kitap & Kitap Bölümleri

2016

2016

Cystic Tumors of the Pancreas

Ceyhan G.

Pathology and Classification of Cystic Tumors of the Pancreas: Epidemiology, 3. Tieftrunk E,Ceyhan CO,Demir IE,Friess H, Editör, Springer International Publishing, Munich, ss.39-50, 2016

2011

2011

Generation and impact of neural invasion in pancreatic cancer.

Ceyhan G.

Pancreatic Cancer/ Book 2, 2. Demir IE,Friess H,Ceyhan GO., Editör, InTech Publishing , Munich, ss.45-46, 2011

Desteklenen Projeler

2016 - 2018

2016 - 2018

The effect of mast cell stabilizers on pain emergence and perception in the chronic panceatitis

Diğer Ülkelerdeki Kamu Kurumları Tarafından Desteklenmiş Proje

Ceyhan G. (Yürütücü)

2016 - 2018

2016 - 2018

The mechanistic characterization of Neuro-Cancer-Stellate-Cell interactions in pancreatic cancer

Diğer Ülkelerdeki Kamu Kurumları Tarafından Desteklenmiş Proje

Ceyhan G. (Yürütücü)

2012 - 2014

2012 - 2014

The impact of Fractalkine/CX3CR1 on the course and pain generation in experimental pancreatitis

Diğer Ülkelerdeki Kamu Kurumları Tarafından Desteklenmiş Proje

Ceyhan G. (Yürütücü)

Bilimsel Kuruluşlardaki Üyelikler / Görevler

2012 - Devam Ediyor

2012 - Devam Ediyor

• International Hepato-Pancreato-Biliary Association/ IHPBA

Üye

2009 - Devam Ediyor

2009 - Devam Ediyor

European Digestive Surgery/EDS

Üye

2009 - Devam Ediyor

2009 - Devam Ediyor

• Vereinigung der Bayerischen Chirurgen/VBC e.V.

Üye

2009 - Devam Ediyor

2009 - Devam Ediyor

American Pancreatic Association/APA

Üye

2008 - Devam Ediyor

2008 - Devam Ediyor

• Deutsche Gesellschaft für Neurogastroenterologie und Motilität/DGNM

Üye

2007 - Devam Ediyor

2007 - Devam Ediyor

• Deutsche Gesellschaft für Allgemein- und Viszeralchirurgie/DGAV

Üye

2005 - Devam Ediyor

2005 - Devam Ediyor

Deutsche Gesellschaft für Chirurgie/DGCH

Üye

2003 - Devam Ediyor

2003 - Devam Ediyor

• International Association of Pancreatology/IAP

Üye

2003 - Devam Ediyor

2003 - Devam Ediyor

European Pancreatic-Club/EPC

Üye

2003 - Devam Ediyor

2003 - Devam Ediyor

• Deutscher Pankreas-Club/DPC e.V.

Üye

2007 - 2013

2007 - 2013

General Assembly of the United European Gastroenterology (UEG)

Üye

Ödüller

Aralık 2010

Aralık 2010

Elected member of the „Academy of Excellence (Exzellenzakademie

Academic General Surgery Germany



Atıflar

Toplam Atıf Sayısı (WOS): 3456

h-indeksi (WOS): 33