ŞEYMA IŞIK

Metrics

Publication

Publication (WoS)

Publication (Scopus)

Citation (WoS)

H-Index (WoS)

Citation (Scopus)

H-Index (Scopus)

Project

UN Sustainable Development Goals

Education

2020 - Present

Doctorate

Acibadem Mehmet Ali Aydinlar University, Graduate School Of Health Sciences, Department Of Medical Biotechnology, Turkey

2017 - 2020

Postgraduate

Acibadem Mehmet Ali Aydinlar University, Graduate School Of Health Sciences, Department Of Medical Biotechnology, Turkey

2011 - 2016

Undergraduate

Yeditepe University, Genetics and Bioengineering, Turkey

Certificates, Courses and Trainings

2024

Organ on a Chip Masterclass

New Product Development

OrChESTRA Project Coordination Team

2021

ISO 13485:2016 Quality Management System for Medical Devices

Quality Management

Prem R&D Consultancy

2021

ISO 13485:2016 Internal Auditor Theorical and Practical training

Quality Management

Prem R&D Consultancy

Research Areas

Biotechnology

Genetic Engineering

Moleculer Biology of Cancer

Bioengineering

Research Areas Based on Academic Activities

Avesis Research Areas

WoS Research Areas

Scopus Research Areas

Articles

2026

1. Investigation of the photophysical, photochemical, and multifunctional biological properties of fluorinated zinc(ii) phthalocyanine functionalized with carboxylic acid

Özay G., Özçeşmeci M., IŞIK Ş., CAN KARANLIK C., Kalkan Burat A., ERDOĞMUŞ A., et al.

Dalton Transactions , vol.55, no.5, pp.2100-2110, 2026 (SCI-Expanded, Scopus)

2026

2. PEGylated isothiocyanate-functionalized zinc(II) phthalocyanine exhibits cell-type dependent photodynamic activity in 2D and 3D tumor models

Özçeşmeci M., IŞIK Ş., Samsunlu T., Kaplan E., YAŞA ATMACA G., Burat A. K., et al.

Journal of Photochemistry and Photobiology B: Biology , vol.275, 2026 (SCI-Expanded, Scopus)

2025

3. Morpholinoethoxy-Substituted Cationic Metal-Free and Metallo Phthalocyanines: In Vitro Photodynamic Therapy Activities, PDT-Induced ROS Level Measurements, and Cellular Death Mechanism

Serhatli M., Isik Ş., Kalkan Burat A., Özçeşmeci M., Hamuryudan E., CAN Ö.

ACS BIO & MED CHEM AU , vol.5, no.4, pp.766-777, 2025 (ESCI)

2025

4. 2D and 3D in vitro photodynamic activities of tetra-substituted symmetric water-soluble cationic zinc(II) phthalocyanines on cancer

IŞIK Ş., Özçeşmeci M., Kalkan Burat A., Hamuryudan E., ERDOĞMUŞ A., CAN Ö., et al.

SCIENTIFIC REPORTS , vol.15, no.1, 2025 (SCI-Expanded, Scopus)

2025

5. Anti-angiogenic effects of cationic zinc (II) phthalocyanine derivatives through photodynamic therapy

Isik Ş., Özçeşmeci M., Kalkan Burat A., Hamuryudan E., CAN Ö., Serhatli M.

SCIENTIFIC REPORTS , vol.15, no.1, pp.2498-0, 2025 (SCI-Expanded, Scopus)

2025

6. Development of a Hydrogel Platform with GBM and Microglia: A Potential Glioblastoma Tumor Model

Işık Ş., YÜCEL D., HASIRCI V. N.

ACS APPLIED BIO MATERIALS , vol.8, no.9, pp.14, 2025 (ESCI, Scopus)

2022

7. **Structure-based engineering of an antiangiogenic scFv antibody for soluble production in E. coli without loss of activity**

Denizci Oncu M., Balcioglu B. K., Ozgur B., Ozturk H. U., Serhatli M., IŞIK Ş., et al.

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY , vol.69, no.5, pp.2122-2137, 2022 (SCI-Expanded, Scopus)

2022

8. **Pegylated metal-free and zinc(II) phthalocyanines: synthesis, photophysicochemical properties and in vitro photodynamic activities against head, neck and colon cancer cell lines**

Akkoc B., Samsunlu T., Isik Ş., Özçeşmeci M., YAŞA ATMACA G., ERDOĞMUŞ A., et al.

DALTON TRANSACTIONS , vol.51, no.26, pp.10136-10147, 2022 (SCI-Expanded, Scopus)

2022

9. **The neutralization effect of montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studies**

Durdagi S., Avsar T., Orhan M. D., Serhatli M., Balcioglu B. K., Ozturk H. U., et al.

MOLECULAR THERAPY , vol.30, no.2, pp.963-974, 2022 (SCI-Expanded, Scopus)

2021

10. Identifying specific matrix metalloproteinase-2-inhibiting peptides through phage display-based subtractive screening

Ozdemir Bahadir A., Balcioglu B. K., Serhatli M., IŞIK Ş., Erdag B.

TURKISH JOURNAL OF BIOLOGY , vol.45, no.6, pp.674-682, 2021 (SCI-Expanded, Scopus, TRDizin)

Papers Presented at Peer-Reviewed Scientific Conferences

2024

1. Nerve Tissue Model Development On A Micropatterned Surface

Tamay D. G., Arslantunali-Sahin D., IŞIK Ş., Kole G. E., YÜCEL D., Hasirci N., et al.

7th TERMIS World Congress, Washington, United States Of America, 25 - 28 June 2024, vol.30, (Summary Text)

2024

2. Nerve Tissue Model Development on a Micropatterned Surface

Tamay D. G., ARSLANTUNALI ŞAHİN D., Işık Ş., KÖLE G. E., YÜCEL D., HASIRCI N., et al.

7th TERMIS (Tissue Engineering & Regenerative Medicine International Society) World Congress, Seattle Washington, United States Of America, 25 - 28 June 2024, (Summary Text)

2024

3. Production of an in vitro glioblastoma tumor microenvironment model with HAMA/dECM hydrogel

Yücel D., Hasırcı V. N., Işık Ş.

12th World Biomaterials Congress (WBC), Daegu, South Korea, 26 - 31 May 2024, (Summary Text)

2022

4. Development of a Nerve Tissue Model on a Micropatterned Surfacefor Axon Guidance and Neural Regeneration Investigations

Yücel D., Hasırcı V. N., Arslantunali Şahin D., Tamay D., Köle G. E., Işık Ş., et al.

26th International Biomedical and Science and Technology Symposium (BIOMED2022), Ankara, Turkey, 25 - 27 November 2022, pp.1, (Summary Text)

Funded Projects

2024 - 2025

In Vitro Glioblastoma Modeli Oluşturulması Ve Doğrulanması

TUBITAK Project , 1002 - Quick Support Program

Yücel D., Hasırcı V. N., Işık Ş. (Executive)

2021 - 2024

Mikrodesenli Yüzey Üzerinde Sinir Doku Modeli Oluşturulması, Akson Yönlendirme ve Sinir Hasarı İyileşme Süreçlerinin İncelenmesi

TUBITAK Project , 1001 - Program for Supporting Scientific and Technological Research Projects

2020 - 2021

Development of scFv-based recombinant neutralizing antibody against COVID-19

TUBITAK Project , 1004 - Mükemmeliyet Merkezi Destek Programı FAZ I

2018 - 2021

,

WoS Research Areas: Cell & Tissue Engineering, Materials Science Biomaterials, Materials Science Multidisciplinary, Neurosciences, Cell Biology

Scopus Research Areas: Materials Science (miscellaneous), Materials Chemistry, General Neuroscience, Cell Biology

Avesis Research Areas: Biotechnology, Genetic Engineering, Moleculer Biology of Cancer, Bioengineering

Metrics

Publication

Publication (WoS)

Publication (Scopus)

Citation (WoS)

H-Index (WoS)

Citation (Scopus)

H-Index (Scopus)

Project

Education

Doctorate

Acibadem Mehmet Ali Aydinlar University, Graduate School Of Health Sciences, Department Of Medical Biotechnology, Turkey

Postgraduate

Acibadem Mehmet Ali Aydinlar University, Graduate School Of Health Sciences, Department Of Medical Biotechnology, Turkey

Undergraduate

Yeditepe University, Genetics and Bioengineering, Turkey

Certificates, Courses and Trainings

Organ on a Chip Masterclass

New Product Development

OrChESTRA Project Coordination Team

ISO 13485:2016 Quality Management System for Medical Devices

Quality Management

Prem R&D Consultancy

ISO 13485:2016 Internal Auditor Theorical and Practical training

Quality Management

Prem R&D Consultancy

Research Areas

Biotechnology

Genetic Engineering

Moleculer Biology of Cancer

Bioengineering

Research Areas Based on Academic Activities

Avesis Research Areas

WoS Research Areas

Scopus Research Areas

Articles

1. Investigation of the photophysical, photochemical, and multifunctional biological properties of fluorinated zinc(ii) phthalocyanine functionalized with carboxylic acid

Özay G., Özçeşmeci M., IŞIK Ş., CAN KARANLIK C., Kalkan Burat A., ERDOĞMUŞ A., et al.

Dalton Transactions , vol.55, no.5, pp.2100-2110, 2026 (SCI-Expanded, Scopus)

2. PEGylated isothiocyanate-functionalized zinc(II) phthalocyanine exhibits cell-type dependent photodynamic activity in 2D and 3D tumor models

Özçeşmeci M., IŞIK Ş., Samsunlu T., Kaplan E., YAŞA ATMACA G., Burat A. K., et al.

Journal of Photochemistry and Photobiology B: Biology , vol.275, 2026 (SCI-Expanded, Scopus)

3. Morpholinoethoxy-Substituted Cationic Metal-Free and Metallo Phthalocyanines: In Vitro Photodynamic Therapy Activities, PDT-Induced ROS Level Measurements, and Cellular Death Mechanism

Serhatli M., Isik Ş., Kalkan Burat A., Özçeşmeci M., Hamuryudan E., CAN Ö.

ACS BIO & MED CHEM AU , vol.5, no.4, pp.766-777, 2025 (ESCI)

4. 2D and 3D in vitro photodynamic activities of tetra-substituted symmetric water-soluble cationic zinc(II) phthalocyanines on cancer

IŞIK Ş., Özçeşmeci M., Kalkan Burat A., Hamuryudan E., ERDOĞMUŞ A., CAN Ö., et al.

SCIENTIFIC REPORTS , vol.15, no.1, 2025 (SCI-Expanded, Scopus)

5. Anti-angiogenic effects of cationic zinc (II) phthalocyanine derivatives through photodynamic therapy

Isik Ş., Özçeşmeci M., Kalkan Burat A., Hamuryudan E., CAN Ö., Serhatli M.

SCIENTIFIC REPORTS , vol.15, no.1, pp.2498-0, 2025 (SCI-Expanded, Scopus)

6. Development of a Hydrogel Platform with GBM and Microglia: A Potential Glioblastoma Tumor Model

Işık Ş., YÜCEL D., HASIRCI V. N.

ACS APPLIED BIO MATERIALS , vol.8, no.9, pp.14, 2025 (ESCI, Scopus)

7. Structure-based engineering of an antiangiogenic scFv antibody for soluble production in E. coli without loss of activity

Denizci Oncu M., Balcioglu B. K., Ozgur B., Ozturk H. U., Serhatli M., IŞIK Ş., et al.

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY , vol.69, no.5, pp.2122-2137, 2022 (SCI-Expanded, Scopus)

8. Pegylated metal-free and zinc(II) phthalocyanines: synthesis, photophysicochemical properties and in vitro photodynamic activities against head, neck and colon cancer cell lines

Akkoc B., Samsunlu T., Isik Ş., Özçeşmeci M., YAŞA ATMACA G., ERDOĞMUŞ A., et al.

DALTON TRANSACTIONS , vol.51, no.26, pp.10136-10147, 2022 (SCI-Expanded, Scopus)

9. The neutralization effect of montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studies

Durdagi S., Avsar T., Orhan M. D., Serhatli M., Balcioglu B. K., Ozturk H. U., et al.

MOLECULAR THERAPY , vol.30, no.2, pp.963-974, 2022 (SCI-Expanded, Scopus)

10. Identifying specific matrix metalloproteinase-2-inhibiting peptides through phage display-based subtractive screening

Ozdemir Bahadir A., Balcioglu B. K., Serhatli M., IŞIK Ş., Erdag B.

TURKISH JOURNAL OF BIOLOGY , vol.45, no.6, pp.674-682, 2021 (SCI-Expanded, Scopus, TRDizin)

Papers Presented at Peer-Reviewed Scientific Conferences

1. Nerve Tissue Model Development On A Micropatterned Surface

Tamay D. G., Arslantunali-Sahin D., IŞIK Ş., Kole G. E., YÜCEL D., Hasirci N., et al.

7th TERMIS World Congress, Washington, United States Of America, 25 - 28 June 2024, vol.30, (Summary Text)

2. Nerve Tissue Model Development on a Micropatterned Surface

Tamay D. G., ARSLANTUNALI ŞAHİN D., Işık Ş., KÖLE G. E., YÜCEL D., HASIRCI N., et al.

7th TERMIS (Tissue Engineering &amp; Regenerative Medicine International Society) World Congress, Seattle Washington, United States Of America, 25 - 28 June 2024, (Summary Text)

3. Production of an in vitro glioblastoma tumor microenvironment model with HAMA/dECM hydrogel

Yücel D., Hasırcı V. N., Işık Ş.

7. **Structure-based engineering of an antiangiogenic scFv antibody for soluble production in E. coli without loss of activity**

8. **Pegylated metal-free and zinc(II) phthalocyanines: synthesis, photophysicochemical properties and in vitro photodynamic activities against head, neck and colon cancer cell lines**

9. **The neutralization effect of montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studies**

7th TERMIS (Tissue Engineering & Regenerative Medicine International Society) World Congress, Seattle Washington, United States Of America, 25 - 28 June 2024, (Summary Text)

4. Development of a Nerve Tissue Model on a Micropatterned Surfacefor Axon Guidance and Neural Regeneration Investigations