IgG(4) production is confined to human IL-10-producing regulatory B cells that suppress antigen-specific immune responses


van de Veen W., Stanic B., Yaman G., Wawrzyniak M., Soellner S., Akdis D. G. , ...More

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol.131, no.4, pp.1204-1212, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 131 Issue: 4
  • Publication Date: 2013
  • Doi Number: 10.1016/j.jaci.2013.01.014
  • Title of Journal : JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
  • Page Numbers: pp.1204-1212

Abstract

Background: IL-10-producing regulatory B cells suppress immune responses, and lack of these cells leads to exacerbated symptoms in mouse models of chronic inflammation, transplantation, and chronic infection. IgG(4) is a blocking antibody isotype with anti-inflammatory potential that is induced in human high-dose antigen tolerance models.