IgG(4) production is confined to human IL-10-producing regulatory B cells that suppress antigen-specific immune responses


van de Veen W., Stanic B., Yaman G., Wawrzyniak M., Soellner S., Akdis D. G. , et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, cilt.131, ss.1204-1212, 2013 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 131 Konu: 4
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.jaci.2013.01.014
  • Dergi Adı: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
  • Sayfa Sayısı: ss.1204-1212

Özet

Background: IL-10-producing regulatory B cells suppress immune responses, and lack of these cells leads to exacerbated symptoms in mouse models of chronic inflammation, transplantation, and chronic infection. IgG(4) is a blocking antibody isotype with anti-inflammatory potential that is induced in human high-dose antigen tolerance models.