The influence of obesity on ICSI outcomes in women with polycystic ovary syndrome.


Ozgun M. T. , Uludag S., Oner G., Batukan C. , Aygen E. M. , Sahin Y.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, cilt.31, ss.245-9, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 31 Konu: 3
  • Basım Tarihi: 2011
  • Doi Numarası: 10.3109/01443615.2010.546906
  • Dergi Adı: Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
  • Sayfa Sayıları: ss.245-9

Özet

The objective of the study was to compare intracytoplasmic sperm injection (ICSI) outcome and gonadotropin doses between obese women with PCOS and non-obese patients with PCOS. This follow-up study represents ICSI outcomes in obese women with PCOS (BMI >= 30 kg/m(2)) compared with non-obese women with PCOS (BMI < 30 kg/m(2)). Obese (n=18) and non-obese (n=26) women with PCOS underwent long protocol pituitary suppression, ovarian stimulation and ICSI with fresh embryo transfer. Obese patients with PCOS required higher doses of gonadotropin (2994 IU vs 1719 IU; p < 0.001). Miscarriage rate was significantly higher in obese women compared with the non-obese women with PCOS (60% vs 6.7%, p=0.002). Our results are valuable for counselling couples before initiation of assisted reproduction techniques (ART).