Vanishing bile duct and Stevens-Johnson syndrome associated with ciprofloxacin treated with tacrolimus.

Okan G., Yaylaci S., Peker O., Kaymakoglu S., Saruc M.

World journal of gastroenterology, vol.14, no.29, pp.4697-700, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 29
  • Publication Date: 2008
  • Doi Number: 10.3748/wjg.14.4697
  • Journal Name: World journal of gastroenterology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.4697-700
  • Keywords: Stevens-Johnson syndrome, vanishing bile duct syndrome, ciprofloxacin, tacrolimus, TOXIC EPIDERMAL NECROLYSIS, DRUG, HYPERSENSITIVITY, CHILD
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Stevens-Johnson syndrome (SIS) is a serious and potentially life-threatening disease. Vanishing bile duct syndrome (VBDS) is a rare cause of progressive cholestasis. Both syndromes are mostly related with drugs. We report a case of a patient with ciprofloxacin-incluced SIS and acute onset of VBDS, and reviewed the related literature. It is the first case of ciprofloxacin-induced VBDS successfully treated with tacrolimus. This case reminds physicians of the importance of drug reactions, their severity techniques for diagnosis and methods of management. (c) 2008 The WJG Press. All rights reserved.