Vanishing bile duct and Stevens-Johnson syndrome associated with ciprofloxacin treated with tacrolimus.

Okan G., Yaylaci S. , Peker O., Kaymakoglu S., Saruc M.

World journal of gastroenterology, vol.14, no.29, pp.4697-700, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 29
  • Publication Date: 2008
  • Doi Number: 10.3748/wjg.14.4697
  • Title of Journal : World journal of gastroenterology
  • Page Numbers: pp.4697-700
  • Keywords: Stevens-Johnson syndrome, vanishing bile duct syndrome, ciprofloxacin, tacrolimus, TOXIC EPIDERMAL NECROLYSIS, DRUG, HYPERSENSITIVITY, CHILD


Stevens-Johnson syndrome (SIS) is a serious and potentially life-threatening disease. Vanishing bile duct syndrome (VBDS) is a rare cause of progressive cholestasis. Both syndromes are mostly related with drugs. We report a case of a patient with ciprofloxacin-incluced SIS and acute onset of VBDS, and reviewed the related literature. It is the first case of ciprofloxacin-induced VBDS successfully treated with tacrolimus. This case reminds physicians of the importance of drug reactions, their severity techniques for diagnosis and methods of management. (c) 2008 The WJG Press. All rights reserved.