EPILEPSY RESEARCH, vol.95, pp.1-8, 2011 (SCI-Expanded)
Article / Article
Science Citation Index Expanded (SCI-EXPANDED)
Lamotrigine, Genetic polymorphism, Glucuronidation, Pharmacogenomics, Pharmacotherapy, ANTIEPILEPTIC DRUGS, GLUCURONIDATION, PHARMACOKINETICS, PREGNANCY, POPULATION, PLASMA
Acibadem Mehmet Ali Aydinlar University Affiliated:
Lamotrigine (LTG) which has a widespread use in epilepsy treatment as an antiepileptic agent is metabolized by UDP-glucuronosyl transferase (UGT) enzymes. In this study, single nucleotide polymorphisms, P24T and L48V, of the UGT1A4 enzyme have been investigated in a Turkish population of patients with epilepsy (n=131) by comparing serum levels of LTG of wild type and polymorphic subjects.