The relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy

Gulcebi M. I., Ozkaynakci A., GÖREN M. Z., GÜLHAN R., ÖZKARA Ç., Onat F.

EPILEPSY RESEARCH, vol.95, pp.1-8, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 95
  • Publication Date: 2011
  • Doi Number: 10.1016/j.eplepsyres.2011.01.016
  • Journal Name: EPILEPSY RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1-8
  • Keywords: Lamotrigine, Genetic polymorphism, Glucuronidation, Pharmacogenomics, Pharmacotherapy, ANTIEPILEPTIC DRUGS, GLUCURONIDATION, PHARMACOKINETICS, PREGNANCY, POPULATION, PLASMA
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Lamotrigine (LTG) which has a widespread use in epilepsy treatment as an antiepileptic agent is metabolized by UDP-glucuronosyl transferase (UGT) enzymes. In this study, single nucleotide polymorphisms, P24T and L48V, of the UGT1A4 enzyme have been investigated in a Turkish population of patients with epilepsy (n=131) by comparing serum levels of LTG of wild type and polymorphic subjects.