The relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy


Gulcebi M. I. , Ozkaynakci A., GÖREN M. Z. , GÜLHAN R., ÖZKARA Ç., Onat F.

EPILEPSY RESEARCH, vol.95, pp.1-8, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 95
  • Publication Date: 2011
  • Doi Number: 10.1016/j.eplepsyres.2011.01.016
  • Journal Name: EPILEPSY RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.1-8
  • Keywords: Lamotrigine, Genetic polymorphism, Glucuronidation, Pharmacogenomics, Pharmacotherapy, ANTIEPILEPTIC DRUGS, GLUCURONIDATION, PHARMACOKINETICS, PREGNANCY, POPULATION, PLASMA
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Lamotrigine (LTG) which has a widespread use in epilepsy treatment as an antiepileptic agent is metabolized by UDP-glucuronosyl transferase (UGT) enzymes. In this study, single nucleotide polymorphisms, P24T and L48V, of the UGT1A4 enzyme have been investigated in a Turkish population of patients with epilepsy (n=131) by comparing serum levels of LTG of wild type and polymorphic subjects.