Personalized Reference Intervals in Laboratory Medicine: A New Model Based on Within-Subject Biological Variation.

Coşkun A. , Sandberg S., Unsal I., Cavusoglu C., Serteser M. , Kilercik M. , ...More

Clinical chemistry, vol.67, pp.374-384, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 67
  • Publication Date: 2021
  • Doi Number: 10.1093/clinchem/hvaa233
  • Title of Journal : Clinical chemistry
  • Page Numbers: pp.374-384


BACKGROUND: The concept of personalized medicine has received widespread attention in the last decade. However, personalized medicine depends on correct diagnosis and monitoring of patients, for which personalized reference intervals for laboratory tests may be beneficial. In this study, we propose a simple model to generate personalized reference intervals based on historical, previously analyzed results, and data on analytical and within-subject biological variation.