Personalized Reference Intervals in Laboratory Medicine: A New Model Based on Within-Subject Biological Variation.

Coşkun A., Sandberg S., Unsal I., Cavusoglu C., Serteser M., Kilercik M., ...Daha Fazla

Clinical chemistry, cilt.67, ss.374-384, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 67
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1093/clinchem/hvaa233
  • Dergi Adı: Clinical chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.374-384
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

BACKGROUND: The concept of personalized medicine has received widespread attention in the last decade. However, personalized medicine depends on correct diagnosis and monitoring of patients, for which personalized reference intervals for laboratory tests may be beneficial. In this study, we propose a simple model to generate personalized reference intervals based on historical, previously analyzed results, and data on analytical and within-subject biological variation.