Syntheses of neoglycolipids with hexitol spacers between the saccharidic and the lipidic parts


Lafont D., Gross B., Kleinegesse R., DUMOULIN F. , Boullanger P.

CARBOHYDRATE RESEARCH, cilt.331, ss.107-117, 2001 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 331 Konu: 2
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1016/s0008-6215(01)00019-2
  • Dergi Adı: CARBOHYDRATE RESEARCH
  • Sayfa Sayıları: ss.107-117

Özet

Four neoglycolipids having 2-amino-2-deoxy-D-glucose or D-galactose moieties linked to the lipidic parr by a glucitol or a mannitol spacer-arm have been synthesized. The key step of the synthetic strategy was the regiospecific or regioselective beta -glycosylation of partially protected glucitol or mannitol accepters by either 3,4,6-tri-O-acetyl-2-deoxy-2-iodo-alpha -D-mannopyranosyl azide or 2,3,4,6-tetra-O-benzoyl-alpha -D-galactopyranosyl trichloroacetimidate donors. (C) 2001 Elsevier Science Ltd. All rights reserved.