Outcomes of gamma knife treatment for solid intracranial hemangioblastomas

Karabagli H., Genc A., Karabagli P., ABACIOGLU M. U., Seker A., Kilic T.

JOURNAL OF CLINICAL NEUROSCIENCE, cilt.17, sa.6, ss.706-710, 2010 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 6
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.jocn.2009.09.028
  • Dergi Adı: JOURNAL OF CLINICAL NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.706-710
  • Anahtar Kelimeler: Gamma knife, Hemangioblastoma, Radiosurgery, Von Hippel-Lindau disease, CENTRAL-NERVOUS-SYSTEM, HIPPEL-LINDAU-SYNDROME, STEREOTACTIC RADIOSURGERY, NATURAL-HISTORY, SURGERY
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

The aim of this study was to examine the results of gamma knife radiosurgery for 13 patients with residual/recurrent or newly diagnosed solid hemangioblastomas. The 13 patients had 34 solid hemangioblastomas, and all patients underwent gamma knife radiosurgery. Seven patients had von Hippel-Lindau disease and six had sporadic disease. When individual lesions were considered, the overall mean dose at the tumor periphery was 15.8 Gy (range: 12-25 Gy) and the average maximum tumor dose was 31.6 Gy (range: 24-50 Gy). The mean duration of follow-up with MRI was 50.2 months. At the last follow-up evaluation, growth control was achieved for all tumors (partial remission in three tumors [8.8%] and no change in 31 tumors [91.2%]). No radiation-related complications were encountered. Our findings reinforce the view that gamma knife radiosurgery is effective and safe for the management of solid hemangioblastomas with a diameter less than 3 cm, whether they are sporadic or associated with von Hippel-Lindau disease. The high response rate and lack of any radiation-induced side-effects confirms the suitability of the doses used in the present study. (C) 2009 Elsevier Ltd. All rights reserved.