Differential diagnosis of smooth muscle tumors utilizing p53, pTEN and Ki-67 expression with estrogen and progesterone receptors

Gokasalan H., Turkeri L., Kavak Z., Eren F., Sismanoglu A., Ilvan S., ...More

GYNECOLOGIC AND OBSTETRIC INVESTIGATION, vol.59, no.1, pp.36-40, 2005 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 59 Issue: 1
  • Publication Date: 2005
  • Doi Number: 10.1159/000080933
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.36-40
  • Keywords: p53, pTEN, Ki-67, estrogen receptor, progesterone receptor, smooth muscle tumors, UTERINE, LEIOMYOSARCOMA, PROTEIN
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No


Background/Aim: To investigate the expression and value for diagnosis of the genes, p53 and pTEN, the protein, Ki-67, and the receptors, estrogen and progesterone, in differentiating smooth muscle tumors of the uterus. Material and Method: Seventeen samples of leiomyosarcoma, 2 smooth muscle tumors with uncertain malignant potential ( STUMP), 9 atypical myomas and 15 leiomyomas were stained immunohistochemically. The chi(2) test was used for the statistical analysis of the data. Results: The malignant side of the spectrum was strongly stained for Ki-67 and p53 while uniformly decreasing toward the benign tumors. The results were found to be statistically significant ( p < 0.0001). The staining for progesterone receptor was also statistically significant, but the tumors that were considered benign, such as leiomyoma and atypical myoma, were the ones strongly stained ( p = 0.005). The expression of estrogen receptor was significant in these tumors, but the p value was very close to the cut-off value ( p = 0.07). As the degree of differentiation of the tumor increased, the trend showed stronger staining for estrogen receptor. However, no difference was detected in the staining properties of the tumors for pTEN ( p = 0.2457). Conclusion: The expression of Ki-67, p53 and progesterone receptors is promising in immunodifferentiation of smooth muscle tumors of the uterus with malignant potential. Copyright (C) 2005 S. Karger AG, Basel.