Spontaneous involution of a non-optic astrocytoma in neurofibromatosis type I: Serial magnetic resonance imaging evaluation

Cakirer S., Karaarslan E.

ACTA RADIOLOGICA, cilt.45, sa.6, ss.669-673, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 45 Konu: 6
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1080/02841850410001150
  • Sayfa Sayıları: ss.669-673


A patient with neurofibromatosis type I (NF1) was followed-up with serial magnetic resonance imaging (MRI) studies over a period of 6 years. A contrast-enhancing lesion of the internal capsule, histologically proven to be pilocytic astrocytoma through stereotactic brain biopsy with mass effect and associated edema, was detected to reveal spontaneous involution on follow-up MRI studies. Although spontaneous regression of gliomas of the optic pathway-hypothalamus in patients with NF1 is relatively common in the literature, spontaneous involution of non-optic (i.e. areas other than optic pathways and hypothalamus) gliomas is rarely reported. Conservative management with follow-up MRI studies should be considered for non-optic glial tumors and tumor-like masses in patients with NF1, and surgical treatment should not be considered unless the lesions exhibit a rapid or unrelenting growth on serial MRI studies or produce significant clinical deterioration.