Spontaneous involution of a non-optic astrocytoma in neurofibromatosis type I: Serial magnetic resonance imaging evaluation

Cakirer S., Karaarslan E.

ACTA RADIOLOGICA, vol.45, no.6, pp.669-673, 2004 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 6
  • Publication Date: 2004
  • Doi Number: 10.1080/02841850410001150
  • Journal Name: ACTA RADIOLOGICA
  • Journal Indexes: Science Citation Index Expanded
  • Page Numbers: pp.669-673


A patient with neurofibromatosis type I (NF1) was followed-up with serial magnetic resonance imaging (MRI) studies over a period of 6 years. A contrast-enhancing lesion of the internal capsule, histologically proven to be pilocytic astrocytoma through stereotactic brain biopsy with mass effect and associated edema, was detected to reveal spontaneous involution on follow-up MRI studies. Although spontaneous regression of gliomas of the optic pathway-hypothalamus in patients with NF1 is relatively common in the literature, spontaneous involution of non-optic (i.e. areas other than optic pathways and hypothalamus) gliomas is rarely reported. Conservative management with follow-up MRI studies should be considered for non-optic glial tumors and tumor-like masses in patients with NF1, and surgical treatment should not be considered unless the lesions exhibit a rapid or unrelenting growth on serial MRI studies or produce significant clinical deterioration.