Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease

Cansev M., Ulus İ. H., Wang L., Maher T. J., Wurtman R. J.

NEUROSCIENCE RESEARCH, cilt.62, sa.3, ss.206-209, 2008 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 62 Sayı: 3
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.neures.2008.07.005
  • Dergi Adı: NEUROSCIENCE RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.206-209
  • Anahtar Kelimeler: Parkinson's disease, Uridine, Docosahexaenoic acid, Dopamine, Tyrosine hydroxylase activity, Synapse, NEURITE OUTGROWTH, PARTIAL LESIONS, FATTY-ACIDS, BRAIN, DOPAMINE, SUPPLEMENTATION, RELEASE, GERBILS, OMEGA-3, SYSTEM
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Administering uridine-5'-monophosphate (UMP) and docosahexaenoic acid (DHA) increases synaptic membranes (as characterized by pre- and post-synaptic proteins) and dendritic spines in rodents. We examined their effects on rotational behavior and dopaminergic markers in rats with partial unilateral 6-hydroxydopamine (6-OHDA)-induced striatal lesions. Rats receiving UMP, DHA, both, or neither, daily, and intrastriatal 6-OHDA 3 clays after treatment onset, were tested for d-amphetamine-induced rotational behavior and dopaminergic markers after 24 and 28 days, respectively. UMP/DHA treatment reduced ipsilateral rotations by 57% and significantly elevated striatal dopamine, tyrosine hydroxylase (TH) activity, TH protein and synapsin-1 on the lesioned side. Hence, giving uridine and DHA may Partially restore dopaminergic neurotransmission in this model of Parkinson's disease. (C) 2008 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.