Bronchiolitis obliterans organizing pneumonia associated with sulfasalazine in a patient with rheumatoid arthritis


Ulubas B., Sahin G., Ozer C., Aydin Ö. , Ozgur E., Apaydin D.

CLINICAL RHEUMATOLOGY, cilt.23, sa.3, ss.249-251, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Konu: 3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1007/s10067-003-0848-5
  • Dergi Adı: CLINICAL RHEUMATOLOGY
  • Sayfa Sayıları: ss.249-251

Özet

Pulmonary toxicity and blood dyscrasias are rare side effects of sulfasalazine. Pulmonary pathology is variable, the most common being eosinophilic pneumonia with peripheral eosinophilia, and interstitial inflammation with or without fibrosis. We here present the case of a 68-year-old female patient treated for 6 months with sulfasalazine for rheumatoid arthritis. On laboratory examination, eosinophil count was 97x10(3) mm(3). Thorocoscopic biopsy was performed . Histopathologic diagnosis was bronchiolitis obliterans organizing pneumonia (BOOP). This is the first case in the literature to present with sulfasalazine-induced BOOP in a patient with seronegative RA.