Idiopathic hirsutism: local and peripheral expression of aromatase (CYP19A) and 5 alpha-reductase genes (SRD5A1 and SRD5A2)

ÇAĞLAYAN A. O., DÜNDAR M., Tanriverdi F., Baysal N. A., ÜNLÜHİZARCI K., ÖZKUL Y., ...Daha Fazla

FERTILITY AND STERILITY, cilt.96, sa.2, ss.479-482, 2011 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 96 Sayı: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.fertnstert.2011.05.040
  • Dergi Adı: FERTILITY AND STERILITY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.479-482
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Objective: To evaluate idiopathic hirsutism etiology via molecular studies testing peripheral and local aromatase and 5 alpha-reductase expression. Design: Assessment of the expression of messenger RNA (mRNA) for type 1 and 2,5 alpha-reductase isoenzyme gene (SDR5A1, SDR5A2) and aromatase (CYP19A) in dermal papillae cells and peripheral blood mononuclear cells. Setting: University hospital. Patient(s): 28 untreated idiopathic hirsute patients and 20 healthy women (controls). Intervention(s): Human skin biopsies and peripheral venous blood. Main Outcome Measure(s): SDR5A1, SDR5A2, CYP19A gene expression in skin biopsies and peripheral blood. Result(s): A statistically significant reduction of SRD5A1, SRD5A2, and CYP19A gene expression was found in the dermal papillae cells and peripheral blood mononuclear cell between the study and control group. Conclusion(s): Further study, including protein expression and enzyme activity assays, are warranted to characterize the paradoxically low gene expression levels of local 5 alpha-reductase and aromatase in women with idiopathic hirsutism. (Fertil Steril (R) 2011;96:479-82. (C) 2011 by American Society for Reproductive Medicine.)