Relationship Between GRK4 Polymorphisms And Essential Hypertension. A Study In A Group Of Turkish Subjects

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Atıf İçin Kopyala

Yıldız H., Kan B., Orun O., Nacar C., Doğan Y., Güneysel Ö., ...Daha Fazla

Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, cilt.15, sa.1, ss.1-7, 2024 (Hakemli Dergi)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 15 Sayı: 1
• Basım Tarihi: 2024
• Doi Numarası: 10.31067/acusaglik.1351877
• Dergi Adı: Acıbadem Üniversitesi Sağlık Bilimleri Dergisi
• Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
• Sayfa Sayıları: ss.1-7
• Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Background/Purpose: G protein-coupled receptor kinase (GRK4) is associated with essential hypertension (EHT). GRK4

regulates sodium balance in the proximal tubules of the kidney. In this study, the possible roles of A142V and A486V

polymorphisms in the development of hypertension were investigated in a Turkish population.

Methods: Genomic DNA was obtained from white blood cells using the standard DNA isolation kit (Roche). Genotypes

of variants of GRK4 were determined by Polymerase chain reaction (PCR) - Restriction fragment length polymorphism

(RFLP) analysis.

Results: In this study, GRKA142V and A486V polymorphisms were found to be associated with EHT in the Turkish

population (P<0.05). The relationship between EHT and the A142V polymorphism was found to be more significant in

men than in women.

Conclusion: Our results show that A142V and A486V polymorphisms of the GRK4 were associated with EHT in a

Turkish population. As far as we know, this is the first study on the association between the GRK4 A142V and A486V

gene polymorphisms and essential hypertension in the Turkish population. GRK4 could be a new therapeutic target for

hypertension.

Keywords: Genetic Polymorphism, G-Protein-Coupled Receptor Kinase 4, Signal Transduction Pathways