Research Information System
Gogus-Kalp-Damar Anestezi ve Yogun Bakim Dernegi Dergisi, vol.9, no.3, pp.124-128, 2003 (Scopus)
In this study we compared the effects of combined anesthesia (general anesthesia+epidural anesthesia) and general anesthesia on pulmonary shunt fraction (Qs/Qt) and oxygenation during one lung ventilation. All patients had thoracic epidural catheters (T6-7, T7-8) preoperatively. The infusion of morphine+bupivacain solution through epidural catheter was started one hour before surgical incision in combined anesthesia group (n=10). In general anesthesia group (n=10), patients have not received any medication through epidural catheter preoperatively and peroperatively. After induction of general anesthesia, arterial and pulmonary arterial catheters were placed. Heart rate, arterial oxygen saturation, pulmonary and systemic arterial pressures, central venous pressure and pulmonary artery occlusion pressure were monitored. Arterial and mixed venous blood gas analyses and hemodynamic measurements were performed and Qs/Qt was calculated during two lung ventilation (T1) and one lung ventilation (T2) in lateral decubitis position. In combined anesthesia group, pulmonary shunt fraction and mixed venous oxygen saturation was higher than general anesthesia group during one lung ventilation (35.7±5.4 %, 27.5±8.2 %, p=0.01, 81.5±7.1 % 75.5±9.4, p=0.12, respectively). In conclusion, the high intrapulmonary shunt fraction in combined anesthesia group can be explained by vasodilatation during epidural anesthesia.