Perineural Mast Cells Are Specifically Enriched in Pancreatic Neuritis and Neuropathic Pain in Pancreatic Cancer and Chronic Pancreatitis

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Demir I. E. , Schorn S., Schremmer-Danninger E., Wang K., Kehl T., Giese N. A. , ...More

PLOS ONE, vol.8, no.3, 2013 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.1371/journal.pone.0060529
  • Journal Name: PLOS ONE
  • Journal Indexes: Science Citation Index Expanded


Background: Pancreatic neuritis is a histopathological hallmark of pancreatic neuropathy and correlates to abdominal neuropathic pain sensation in pancreatic adenocarcinoma (PCa) and chronic pancreatitis (CP). However, inflammatory cell subtypes that compose pancreatic neuritis and their correlation to the neuropathic pain syndrome in PCa and CP are yet unknown.