Spectral effect: each population must have its own normal midnight salivary cortisol reference values determined

Mert M., Tanakol R., Karpuzoglu H., ABBASOĞLU S., YARMAN E. S., Boztepe H., ...More

ARCHIVES OF MEDICAL SCIENCE, vol.9, no.5, pp.872-876, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 5
  • Publication Date: 2013
  • Doi Number: 10.5114/aoms.2013.38681
  • Journal Name: ARCHIVES OF MEDICAL SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.872-876
  • Keywords: midnight salivary cortisol, spectral effect, normal reference range, CUSHINGS-SYNDROME, ADRENAL-FUNCTION, ASSAYS
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Introduction: The mesurement of midnight salivary cortisol provides the most sensitive method for screening of Cushing's sendrome. However the clinical significance of spectral error is the requirement for determination of normal reference values in each population for each test, which will be used as the diagnostic method. Salivary cortisol levels may be affected by individual factors such as nutrition, sleep, medication, activity, and gender. Being a non-invasive method, midnight salivary cortisol (MSC) has been used as a valuable indicator of free plasma cortisol.