Neurological aspects of tuberous sclerosis in relation to MRI/MR spectroscopy findings in children with epilepsy


Yapici Z., Doertcan N., BAYKAL B., Okan F., Dincer A., BAYKAL C., ...More

NEUROLOGICAL RESEARCH, vol.29, no.5, pp.449-454, 2007 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 5
  • Publication Date: 2007
  • Doi Number: 10.1179/016164107x163996
  • Journal Name: NEUROLOGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.449-454
  • Keywords: tuberous sclerosis, magnetic resonance imaging, proton spectroscopy, epilepsy, MAGNETIC-RESONANCE-SPECTROSCOPY, MR SPECTROSCOPY, COMPLEX, MALFORMATIONS, SEVERITY, SEIZURES

Abstract

Our aim was to evaluate the relationship between the neurological outcome of tuberous sclerosis complex ( TSC) and the findings obtained from both cranial magnetic resonance imaging ( MRI) and single voxel proton spectroscopy ( SVPS). MRIs of 13 children who met the diagnostic criteria for TSC were taken. Eleven of these children also underwent a prospective analysis of SVPS. Fisher's exact test and Mann-Whitney U test were used, where applicable, to detect any signs of the imaging data that would indicate poor outcome, or in other words, poor seizure control and/or high degree of mental retardation.