Comparison of four automated serum vitamin B12 assays

Ispir E., Serdar M. A., Ozgurtas T., GÜLBAHAR Ö., Akin K. O., Yesildal F., ...Daha Fazla

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, cilt.53, sa.8, ss.1205-1213, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 53 Sayı: 8
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1515/cclm-2014-0843
  • Dergi Adı: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1205-1213
  • Anahtar Kelimeler: immunoassay, method comparison, vitamin B12, METHYLMALONIC ACID, COBALAMIN, HOMOCYSTEINE, DEFICIENCY, FOLATE
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Background: Diagnosis of vitamin B12 deficiency is generally based on the measurement of serum vitamin B12 levels. However, in selected cases functional indices of vitamin B12, such as methylmalonic acid (MMA) and homocysteine (HCY), are needed. Here we compare the performance of four automated total vitamin B12 assays and also investigate how these assays relate to functional indices of vitamin B12 status.