Relationships between visceral/subcutaneous adipose tissue FABP4 expression and coronary atherosclerosis in patients with metabolic syndrome

GÖRMEZ S. , ERDİM R. , Akan G., Caynak B., Duran C., Gunay D., ...More

CARDIOVASCULAR PATHOLOGY, vol.46, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46
  • Publication Date: 2020
  • Doi Number: 10.1016/j.carpath.2019.107192
  • Keywords: Coronary atherosclerosis, Fatty acid-binding protein 4, Epicardial adipose tissue, Epicardial adipose tissue volume, Metabolic syndrome, Single nucleotide polymorphism, ACID-BINDING PROTEIN, EPICARDIAL FAT VOLUME, INSULIN-RESISTANCE, LIPID-METABOLISM, ARTERY-DISEASE, RISK, AP2, CALCIFICATION, ASSOCIATION, ADIPOKINES


Background: Cytoplasmic fatty acid-binding proteins facilitate the transport of lipids to specific compartments in cells. Fatty acid-binding protein 4 (FABP4), also known as aP2 or A-FABP, plays a key role in the development of atherosclerosis, insulin resistance, obesity, and metabolic syndrome (MS). The FABP4 polymorphisms are associated with protein expression changes in vitro and metabolic and vascular alterations in vivo. The aim of this study was to investigate the association between FABP4 messenger ribonucleic acid (mRNA) expression levels in epicardial (EAT), pericardial (PAT), and subcutaneous adipose tissues (SAT), and the extent of coronary atherosclerosis in coronary artery disease (CAD) patients with MS. Furthermore, the relationship between the extent of coronary atherosclerosis and epicardial adipose tissue volume (EATV) and FABP4 gene variations was evaluated.