Three clinical syndromes of schizophrenia: A SPECT study

Aksaray G., Kaptanoglu C., Vardareli E., Ak I., Seber G.

NEUROSCIENCE RESEARCH COMMUNICATIONS, cilt.22, sa.3, ss.147-152, 1998 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 3
  • Basım Tarihi: 1998
  • Dergi Adı: NEUROSCIENCE RESEARCH COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI)
  • Sayfa Sayıları: ss.147-152
  • Anahtar Kelimeler: single-photon emission computed tomography (SPECT), clinical syndrome, schizophrenia, CEREBRAL BLOOD-FLOW, EMISSION COMPUTED-TOMOGRAPHY, HYPOFRONTALITY, DYSFUNCTION, SYMPTOMS, PATTERNS, PET
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

The present study examines whether the three clinical syndromes(psychomotor poverty, disorganisation, reality distortion) are associated with unique patterns of regional cerebral blood flow(rCBF) in the cortex, as measured by single-photon emission computed tomography (SPECT). rCBF was measured in relative terms with Tc99m-HmPAO and SPECT in 20 schizophrenic patients classified according to DSM-III-R. Ten normals served as controls. Current and past psychiatric functioning was assessed by using the Brief Psychiatric Rating Scale(BPRS) and the Structured Clinical Interview for DSM-III-R. Hypoperfusion was observed in right middle temporal (p<0.05), right superior temporal (p<0.001), left superior temporal (p<0.01) and left thalamus (p<0.05) areas of patients. We found a moderate negative association of tracer uptake in left superior temporal with psychomotor poverty(p<0.05).