Three clinical syndromes of schizophrenia: A SPECT study

Aksaray G., Kaptanoglu C., Vardareli E., Ak I., Seber G.

NEUROSCIENCE RESEARCH COMMUNICATIONS, vol.22, no.3, pp.147-152, 1998 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 3
  • Publication Date: 1998
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI)
  • Page Numbers: pp.147-152
  • Keywords: single-photon emission computed tomography (SPECT), clinical syndrome, schizophrenia, CEREBRAL BLOOD-FLOW, EMISSION COMPUTED-TOMOGRAPHY, HYPOFRONTALITY, DYSFUNCTION, SYMPTOMS, PATTERNS, PET
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No


The present study examines whether the three clinical syndromes(psychomotor poverty, disorganisation, reality distortion) are associated with unique patterns of regional cerebral blood flow(rCBF) in the cortex, as measured by single-photon emission computed tomography (SPECT). rCBF was measured in relative terms with Tc99m-HmPAO and SPECT in 20 schizophrenic patients classified according to DSM-III-R. Ten normals served as controls. Current and past psychiatric functioning was assessed by using the Brief Psychiatric Rating Scale(BPRS) and the Structured Clinical Interview for DSM-III-R. Hypoperfusion was observed in right middle temporal (p<0.05), right superior temporal (p<0.001), left superior temporal (p<0.01) and left thalamus (p<0.05) areas of patients. We found a moderate negative association of tracer uptake in left superior temporal with psychomotor poverty(p<0.05).