Challenges in early diagnosis of primary cutaneous CD8+aggressive epidermotropic cytotoxic T-cell lymphoma: a case series of four patients

ONSUN N., DİZMAN D., EMİROĞLU N., YILDIZ P., Akaslan T. C., Tosuner Z., ...More

EUROPEAN JOURNAL OF DERMATOLOGY, vol.30, no.4, pp.358-361, 2020 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.1684/ejd.2020.3843
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, CAB Abstracts, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.358-361
  • Keywords: aggressive, epidermotropic, CD8+, cutaneous T-cell lymphoma
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes


Background Primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma (AECTCL) is a rare and aggressive lymphoma characterised by ulcerated lesions and a poor prognosis. Objectives To present a case series of four previously misdiagnosed AECTCL patients and discuss the importance of early diagnosis. Materials and Methods All patients in this study were identified from the database of the Dermatology Department of the Medical School of Bezmialem Vakif University, based on clinical and histopathological diagnosis of AECTCL between 2010 and 2018. Results AECTCL cases may mimic many benign dermatoses and accurate diagnosis may be delayed. Conclusion Because of its poor prognosis, early diagnosis of AECTCL may be helpful in improving the likelihood of patient survival, but further study is needed to address the challenges in diagnosing this rare and aggressive lymphoma