COX-2 GENE VARIANTS IN BIPOLAR DISORDER-I

ÖZDEMİRCAN A., DAŞDEMİR S., KÜÇÜKALİ C. İ., Bireller E. S., Ozturk H., ÇAKMAKOĞLU B.

PSYCHIATRIA DANUBINA, cilt.27, sa.4, ss.385-389, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 4
  • Basım Tarihi: 2015
  • Dergi Adı: PSYCHIATRIA DANUBINA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Sayfa Sayıları: ss.385-389
  • Anahtar Kelimeler: bipolar disorder-I, inflammation, COX-2, polymorphism, CYCLOOXYGENASE-1 AND-2, EXPRESSION, SCHIZOPHRENIA, LOCALIZATION, INFLAMMATION, ASSOCIATION, COMORBIDITY, PHYSIOLOGY, SYSTEM, MANIA
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Background: Bipolar disorder-I (BD-I) is a complex illness, and multiple genes and environmental factors determine its pathogenesis. Several studies have ascertained that BD-I and inflammation are linked through shared genetic polymorphisms and gene expression, as well as altered cytokine levels. COX-2 gene polymorphisms affecting COX-2 levels may be associated with BD-I by altering the inflammatory response.