Glycemic Variability Promotes Both Local Invasion and Metastatic Colonization by Pancreatic Ductal Adenocarcinoma


Jian Z., Cheng T., Zhang Z., Raulefs S., Shi K., Steiger K., ...Daha Fazla

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, cilt.6, ss.429-449, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 6 Konu: 4
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.jcmgh.2018.07.003
  • Dergi Adı: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
  • Sayfa Sayıları: ss.429-449

Özet

BACKGROUND & AIMS: Although nearly half of pancreatic ductal adenocarcinoma (PDAC) patients have diabetes mellitus with episodes of hyperglycemia, its tumor microenvironment is hypoglycemic. Thus, it is crucial for PDAC cells to develop adaptive mechanisms dealing with oscillating glucose levels. So far, the biological impact of such glycemic variability on PDAC biology remains unknown.