Glycemic Variability Promotes Both Local Invasion and Metastatic Colonization by Pancreatic Ductal Adenocarcinoma


Jian Z., Cheng T., Zhang Z., Raulefs S., Shi K., Steiger K., ...More

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, vol.6, no.4, pp.429-449, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 4
  • Publication Date: 2018
  • Doi Number: 10.1016/j.jcmgh.2018.07.003
  • Title of Journal : CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
  • Page Numbers: pp.429-449

Abstract

BACKGROUND & AIMS: Although nearly half of pancreatic ductal adenocarcinoma (PDAC) patients have diabetes mellitus with episodes of hyperglycemia, its tumor microenvironment is hypoglycemic. Thus, it is crucial for PDAC cells to develop adaptive mechanisms dealing with oscillating glucose levels. So far, the biological impact of such glycemic variability on PDAC biology remains unknown.