Glycemic Variability Promotes Both Local Invasion and Metastatic Colonization by Pancreatic Ductal Adenocarcinoma

Jian Z., Cheng T., Zhang Z., Raulefs S., Shi K., Steiger K., ...More

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, vol.6, no.4, pp.429-449, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 4
  • Publication Date: 2018
  • Doi Number: 10.1016/j.jcmgh.2018.07.003
  • Journal Name: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.429-449
  • Keywords: Pancreatic Cancer, Glucose Metabolism, Metastasis, Retinoic Acid, DIABETES-MELLITUS, METFORMIN USE, CANCER, SURVIVAL, RESECTION, IMPACT, RISK, METABOLISM, MUTATIONS, PATTERNS
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

BACKGROUND & AIMS: Although nearly half of pancreatic ductal adenocarcinoma (PDAC) patients have diabetes mellitus with episodes of hyperglycemia, its tumor microenvironment is hypoglycemic. Thus, it is crucial for PDAC cells to develop adaptive mechanisms dealing with oscillating glucose levels. So far, the biological impact of such glycemic variability on PDAC biology remains unknown.