Doxorubicin and paclitaxel enhance the antitumor efficacy of vaccines directed against HER 2/neu in a murine mammary carcinoma model


Creative Commons License

Eralp Y., Wang X., Wang J., Maughan M., Polo J., Lachman L.

BREAST CANCER RESEARCH, vol.6, no.4, 2004 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 6 Issue: 4
  • Publication Date: 2004
  • Doi Number: 10.1186/bcr787
  • Journal Name: BREAST CANCER RESEARCH
  • Journal Indexes: Science Citation Index Expanded
  • Keywords: adjuvant treatment, breast cancer, chemotherapy, gene vaccines, immunotherapy, METASTATIC BREAST-CANCER, PHASE-I TRIAL, DNA VACCINATION, T-CELLS, PROTECTIVE IMMUNITY, CYTOKINE PRODUCTION, MONOCLONAL-ANTIBODY, ADJUVANT THERAPY, TUMOR VACCINE, FULL-LENGTH

Abstract

Introduction: The purpose of the present study was to determine whether cytotoxic chemotherapeutic agents administered prior to immunotherapy with gene vaccines could augment the efficacy of the vaccines.