Glutamate release inhibition ineffective in levodopa-induced motor complications


Bara-Jimenez W., Dimitrova T. D. , Sherzai A., Aksu M. , Chase T. N.

MOVEMENT DISORDERS, vol.21, no.9, pp.1380-1383, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 9
  • Publication Date: 2006
  • Doi Number: 10.1002/mds.20976
  • Title of Journal : MOVEMENT DISORDERS
  • Page Numbers: pp.1380-1383

Abstract

Reported benefits of various glutamatergic receptor antagonists in Parkinson's disease (PD) prompted an evaluation of the antidyskinetic effect of a putative glutamate release inhibitor in 15 moderately advanced patients. In a 3-week, double-blind, proof-of-concept study, riluzole (200 mg/day) failed to alter parkinsonian or levodopa-induced motor complication severity. Opposing effects of a generalized inhibition of glutamate-mediated synaptic transmission may limit the usefulness of this approach to treat PD. (c) 2006 Movement Disorder Society.