Glutamate release inhibition ineffective in levodopa-induced motor complications
MOVEMENT DISORDERS, cilt.21, sa.9, ss.1380-1383, 2006 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 21 Sayı: 9
- Basım Tarihi: 2006
- Doi Numarası: 10.1002/mds.20976
- Dergi Adı: MOVEMENT DISORDERS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1380-1383
- Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır
Özet
Reported benefits of various glutamatergic receptor antagonists in Parkinson's disease (PD) prompted an evaluation of the antidyskinetic effect of a putative glutamate release inhibitor in 15 moderately advanced patients. In a 3-week, double-blind, proof-of-concept study, riluzole (200 mg/day) failed to alter parkinsonian or levodopa-induced motor complication severity. Opposing effects of a generalized inhibition of glutamate-mediated synaptic transmission may limit the usefulness of this approach to treat PD. (c) 2006 Movement Disorder Society.