Identification of point mutations and large rearrangements in the BRCA1 gene in 667 Turkish unselected ovarian cancer patients

Aktas, D.; GÜLTEKİN, MURAT; Kabacam, S.; ALİKAŞİFOĞLU, MEHMET; Turan, A.; Tulunay, G.; Kose, Mehmet; Ortac, F.; Yuce, K.; Tuncbilek, E.; Ayhan, A.

doi:10.1016/j.ygyno.2010.05.018

Identification of point mutations and large rearrangements in the BRCA1 gene in 667 Turkish unselected ovarian cancer patients

Atıf İçin Kopyala

Aktas D., GÜLTEKİN M., Kabacam S., ALİKAŞİFOĞLU M., Turan A. T. , Tulunay G., et al.

GYNECOLOGIC ONCOLOGY, cilt.119, ss.131-135, 2010 (SCI İndekslerine Giren Dergi)

Cilt numarası: 119 Konu: 1
Basım Tarihi: 2010
Doi Numarası: 10.1016/j.ygyno.2010.05.018
Dergi Adı: GYNECOLOGIC ONCOLOGY
Sayfa Sayısı: ss.131-135

Özet

Objective. The aim of this study was to evaluate the prevalence and spectrum of a known founder mutation, 5382insC and large genomic rearrangements (LGRs) in BRCA1 in ovarian cancer patients in Turkey. The additional aim was to determine the genetic testing strategy in Turkish breast/ovarian cancer family.