Identification of point mutations and large rearrangements in the BRCA1 gene in 667 Turkish unselected ovarian cancer patients

Aktas, D.; GÜLTEKİN, MURAT; Kabacam, S.; ALİKAŞİFOĞLU, MEHMET; Turan, A.; Tulunay, G.; Kose, Mehmet; Ortac, F.; Yuce, K.; Tuncbilek, E.; Ayhan, A.

doi:10.1016/j.ygyno.2010.05.018

Identification of point mutations and large rearrangements in the BRCA1 gene in 667 Turkish unselected ovarian cancer patients

Aktas D., GÜLTEKİN M., Kabacam S., ALİKAŞİFOĞLU M., Turan A. T. , Tulunay G., ...More

GYNECOLOGIC ONCOLOGY, vol.119, no.1, pp.131-135, 2010 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 119 Issue: 1
Publication Date: 2010
Doi Number: 10.1016/j.ygyno.2010.05.018
Title of Journal : GYNECOLOGIC ONCOLOGY
Page Numbers: pp.131-135

Abstract

Objective. The aim of this study was to evaluate the prevalence and spectrum of a known founder mutation, 5382insC and large genomic rearrangements (LGRs) in BRCA1 in ovarian cancer patients in Turkey. The additional aim was to determine the genetic testing strategy in Turkish breast/ovarian cancer family.