An Uncommon Cause of Hypernatremia in Very Low Birth Weight Premature Infants: Idiopathic Central Diabetes Insipidus

AKTAS S., KAZANCI E., SEMİZ S., Korkmaz A.

CYPRUS JOURNAL OF MEDICAL SCIENCES, vol.6, no.2, pp.177-179, 2021 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.5152/cjms.2021.3261
  • Journal Name: CYPRUS JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.177-179
  • Keywords: Central diabetes insipidus, premature infants, ORAL DESMOPRESSIN, MANAGEMENT
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Central diabetes insipidus (CDI) is a water homeostasis disorder characterized by an inability to concentrate urine because of insufficient production of antidiuretic hormone. Dehydration with hypernatremia can occur during the neonatal period in preterm neonates in association with insensible water loss, high urine output, and reduced sodium excretion. A high index of suspicion is required to diagnose CDI in preterm neonates. We report two cases, who presented persistent hypernatremia with polyuria despite increased fluid supply and low sodium intake. CDI diagnosis was confirmed by the therapeutic test with oral vasopressin analog. Investigations were all normal; CDI was considered idiopathic. Persistent hypernatremia despite increased fluid intake with polyuria, hyposthenuria, low urine output, and high plasma osmolality is the key point for the diagnosis.