The impact of MFG-E8 in chronic pancreatitis: potential for future immunotherapy?

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D'Haese J. G., Demir I. E., Kehl T., Winckler J., Giese N. A., Bergmann F., ...Daha Fazla

BMC GASTROENTEROLOGY, cilt.13, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1186/1471-230x-13-14
  • Dergi Adı: BMC GASTROENTEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: MFG-E8, Chronic pancreatitis, Fractalkine, Fibrosis, Stellate cells, Pain, DEVELOPMENTAL ENDOTHELIAL LOCUS-1, CX3C CHEMOKINE FRACTALKINE, SMOOTH-MUSCLE-CELLS, ACUTE LUNG INJURY, APOPTOTIC CELLS, STELLATE CELLS, ALLERGIC-ASTHMA, MILK, GROWTH, EXPRESSION
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Background: The glycoprotein MFG-E8 mediates phagocytic clearance of apoptotic cells and influences the pathogenesis and progression of inflammatory diseases. MFG-E8 was shown to attenuate the progression of inflammation and to improve survival in septic rats. Accumulating evidence suggests an immunomodulatory link between MFG-E8 and the pro-inflammatory chemokine fractalkine, which may determine the severity of pain, fibrosis, and inflammation in chronic pancreatitis (CP).