The impact of MFG-E8 in chronic pancreatitis: potential for future immunotherapy?


D'Haese J. G. , Demir I. E. , Kehl T., Winckler J., Giese N. A. , Bergmann F., ...More

BMC GASTROENTEROLOGY, vol.13, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13
  • Publication Date: 2013
  • Doi Number: 10.1186/1471-230x-13-14
  • Title of Journal : BMC GASTROENTEROLOGY

Abstract

Background: The glycoprotein MFG-E8 mediates phagocytic clearance of apoptotic cells and influences the pathogenesis and progression of inflammatory diseases. MFG-E8 was shown to attenuate the progression of inflammation and to improve survival in septic rats. Accumulating evidence suggests an immunomodulatory link between MFG-E8 and the pro-inflammatory chemokine fractalkine, which may determine the severity of pain, fibrosis, and inflammation in chronic pancreatitis (CP).