Association of missense substitution of A49T and V89L in the SRD5A2 gene with prostate cancer in Turkish patients

Neijmann, Sebnem; Kural, Alev; Tinay, Ilker; Livaoglu, Ayten; Cevlik, Tulay; Turkeri, LEVENT

doi:10.1515/tjb-2016-0164

Association of missense substitution of A49T and V89L in the SRD5A2 gene with prostate cancer in Turkish patients

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Neijmann S. T., Kural A., Tinay I., Livaoglu A., Cevlik T., Turkeri L.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.42, no.1, pp.37-43, 2017 (SCI-Expanded)

Publication Type: Article / Article
Volume: 42 Issue: 1
Publication Date: 2017
Doi Number: 10.1515/tjb-2016-0164
Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Page Numbers: pp.37-43
Keywords: 5 alpha-Reductase gene, Polymorphism, Prostate cancer, SRD5A2 gene, Missense substitution, 5-ALPHA-REDUCTASE TYPE-II, PATHOLOGICAL CHARACTERISTICS, ANDROGEN PATHWAY, RISK, POLYMORPHISMS, INHIBITORS, MEN, AGGRESSIVENESS, EPIDEMIOLOGY, METAANALYSIS
Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Objective: To determine the association of missense substitution of alanine 49 threonine (A49T) and valine 89 leucine (V89L) in the steroid-5-alpha-reductase type II (SRD5A2) gene with prostate cancer in Turkish patients.