The relation of anthropometric measurements and insulin resistance in patients with polycystic kidney disease

Esen B., Gokmen E. S., Kaya M., Ozkan B., Atay A. E.

JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE, cilt.4, sa.3, ss.127-134, 2016 (Hakemli Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 4 Sayı: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1515/jtim-2016-0029
  • Dergi Adı: JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
  • Sayfa Sayıları: ss.127-134
  • Anahtar Kelimeler: polycystic kidney disease, insulin resistance, anthropometric measurements, obesity, diabetes mellitus, RENAL-FUNCTION, CARDIOVASCULAR EVENTS, RISK-FACTORS, HYPERURICEMIA
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Objective: To examine the frequency of insulin resistance (IR) and its relation with anthropometric measurements in patients with autosomal dominant polycystic kidney disease (ADPKD). Material and Methods: Nonobese 82 patients with ADPKD and 58 age matched healthy controls were enrolled into the study. None of participants were diabetic or receiving renal replacement therapies (RRT). IR was determined by homeostasis model assessment of insulin resistance (HOMA-IR) formula. Tanita body composition analyzer was used for anthropometric measurements. Creatinine clearance of participant were assessed by the modification of diet in renal diseases (MDRD). Results: Patients with ADPKD had significantly higher level of urea and creatinine, microalbuminuria, and lower level of MDRD. Body fat distribution and HOMA-IR in both the groups were similar. Systolic and diastolic blood pressure of patients were higher than those of controls. Conclusion: We failed to determine a higher frequency of IR among patients with ADPKD.