A comparison of the local effectiveness of mitomycin C, aprotinin, and Adcon-L in experimental peridural fibrosis

Kurt G., AYTAR M. H., Dogulu F., Cemil B., Erdem O., Baykaner M. K., ...More

SURGICAL NEUROLOGY, vol.70, no.6, pp.608-613, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 70 Issue: 6
  • Publication Date: 2008
  • Doi Number: 10.1016/j.surneu.2007.07.071
  • Journal Name: SURGICAL NEUROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.608-613
  • Keywords: Peridural fibrosis, Mitomycin C, Aprotinin, Adcon-L, Failed back surgery syndrome, LUMBAR-DISK HERNIATION, ANTINEOPLASTIC DRUGS, ADHESION FORMATION, SCAR FORMATION, LAMINECTOMY, INHIBITION, PREVENTION, DISKECTOMY, PROPHYLAXIS, LAMINOTOMY
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Background: Peridural fibrosis and leptomeningeal adhesion formation are among the common causes of FBSS. Various materials have been used to prevent the compressive effect of postoperative PF on neural structures. We investigated and compared the effects of 3 agents-aprotinin, mitomycin C, and Adcon-L-to PF after lumbar laminectomy in rabbits.