Bone tissue engineering on patterned collagen films: an in vitro study

Ber S., Kose G., Hasirci V. N.

BIOMATERIALS, vol.26, no.14, pp.1977-1986, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 14
  • Publication Date: 2005
  • Doi Number: 10.1016/j.biomaterials.2004.07.007
  • Title of Journal : BIOMATERIALS
  • Page Numbers: pp.1977-1986


This study aimed at guiding osteoblast cells from rat bone marrow on chemically modified and patterned collagen films to study the influence of pattern, on cell guidance. The films were stabilized using different treatment methods including crosslinking with carbodiimide (EDC) and glutaraldehyde, dehydrothermal treatment (DHT), and deposition of calcium phosphate on the collagen membrane.