The unique features and promises of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer

Lo P., Salome Rodriguez-Morgade M., Pandey R. K., Ng D. K. P., Torres T., DUMOULIN F.

CHEMICAL SOCIETY REVIEWS, cilt.49, sa.4, ss.1041-1056, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 49 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1039/c9cs00129h
  • Dergi Adı: CHEMICAL SOCIETY REVIEWS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Chemical Abstracts Core, Communication Abstracts, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1041-1056
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Phthalocyanines exhibit superior photoproperties that make them a surely attractive class of photosensitisers for photodynamic therapy of cancer. Several derivatives are at various phases of clinical trials, and efforts have been put continuously to improve their photodynamic efficacy. To this end, various strategies have been applied to develop advanced phthalocyanines with optimised photoproperties, dual therapeutic actions, tumour-targeting properties and/or specific activation at tumour sites. The advantageous properties and potential of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer are highlighted in this tutorial review.