The unique features and promises of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer


Lo P., Salome Rodriguez-Morgade M., Pandey R. K. , Ng D. K. P. , Torres T., DUMOULIN F.

CHEMICAL SOCIETY REVIEWS, vol.49, no.4, pp.1041-1056, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 49 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.1039/c9cs00129h
  • Title of Journal : CHEMICAL SOCIETY REVIEWS
  • Page Numbers: pp.1041-1056

Abstract

Phthalocyanines exhibit superior photoproperties that make them a surely attractive class of photosensitisers for photodynamic therapy of cancer. Several derivatives are at various phases of clinical trials, and efforts have been put continuously to improve their photodynamic efficacy. To this end, various strategies have been applied to develop advanced phthalocyanines with optimised photoproperties, dual therapeutic actions, tumour-targeting properties and/or specific activation at tumour sites. The advantageous properties and potential of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer are highlighted in this tutorial review.