Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study

Koksal, IFTAHAR; YILMAZ, GÜRDAL; PARLAK, Mehmet; Demirdal, Tuna; Kinikli, Sami; Candan, Mehmet; Kaya, Ali; Akhan, Sila; Aydogdu, Ozcan; Turgut, Huseyin; Gurbuz, Yunus; Dagli, Ozgur; Gokal, Ahmet; Guner, Rahmet; Kuruuzum, Ziya; Tarakci, Huseyin; Beslen, Nuri; Erdogan, Seda; Ozdener, Fatih

doi:10.5152/tjg.2018.16597

Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study

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Koksal I., YILMAZ G., PARLAK M., Demirdal T., Kinikli S., Candan M., ...More

TURKISH JOURNAL OF GASTROENTEROLOGY, vol.29, no.4, pp.464-472, 2018 (SCI-Expanded)

Publication Type: Article / Article
Volume: 29 Issue: 4
Publication Date: 2018
Doi Number: 10.5152/tjg.2018.16597
Journal Name: TURKISH JOURNAL OF GASTROENTEROLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Page Numbers: pp.464-472
Keywords: Chronic hepatitis C infection, liver fibrosis, FibroTest, APRI, Forns index, Fib-4, non-invasive serum biomarkers, SIMPLE NONINVASIVE INDEX, PLATELET RATIO INDEX, HISTOLOGICAL LESIONS, HCV INFECTION, BIOPSY, PREDICTION, VIRUS, FIBROTEST, CIRRHOSIS, MARKERS
Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Background/Aims: The hepatitis C virus (HCV) infection is important cause of chronic hepatitis. Liver biopsy is considered the gold standard for assessment of fibrosis but this procedure is an invasive procedure. We aimed to evaluate the diagnostic efficiency of non-invasive serum biomarkers, separately and in combinations, on liver fibrosis in treatment-naive chronic hepatitis C (CHC) patients.