The ADAPAR Birth Cohort Study: Food Allergy Results at Five Years and New Insights

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Dogruel D., Bingol G., YILMAZ M., ALTINTAŞ D. U.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, vol.169, no.1, pp.57-61, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 169 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.1159/000443831
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.57-61
  • Keywords: Allergic diseases, Birth cohort, Food allergy, Tolerance, NATURAL-HISTORY, PROBIOTICS, PREBIOTICS, CHILDREN, DISEASE, ASTHMA
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No


Background: Although food allergy (FA) is often a transient condition during childhood, when and in whom FA will resolve can be affected by many factors. In this study, we analyzed the data at 5 years on 33 children diagnosed with FA in the ADAPAR (Adana Pediatric Allergy Research) birth cohort study in southern Turkey. Methods: Thirty-three infants detected as having FA at the end of their first year in the ADAPAR study were assessed every 6 months until the age of 5 years. Each follow-up included a clinical examination, questionnaire, blood sampling and a skin-prick test. Results: Culprit allergens were cow's milk (n = 20), eggs (n = 17), chicken meat (n = 1) and bananas (n = 1). Of the 17 patients with egg allergy, 14 developed complete tolerance and 1 developed partial tolerance (i.e. tolerance to baked food). Of the 20 patients with milk allergy, complete tolerance was observed in 16 and partial tolerance in 1. The mean age of tolerance to egg was 22.4 +/- 7.5 months and to cow's milk, it was 20.9 +/- 1.1 months. Complete tolerance developed in 1 case allergic to chicken meat and in 1 case allergic to banana. Other allergic conditions were also determined: allergic rhinitis in 27.2%, atopic dermatitis in 21.2%, asthma in 9%, urticaria in 9% and drugs in 9%. Conclusions: Our results confirm early and high tolerance rates before school age in children with food allergies that started in infancy. This will help pediatricians to give more informed advice to parents of infants with cow's milk or hen's egg allergy. (C) 2016 S. Karger AG, Basel